A5068942402- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Cardiac Health and Mental Health
- Venous Thromboembolism Diagnosis and Management
- Chemotherapy-induced cardiotoxicity and mitigation
- Health Systems, Economic Evaluations, Quality of Life
- Mechanical Circulatory Support Devices
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrest and Resuscitation
- Streptococcal Infections and Treatments
- Lipoproteins and Cardiovascular Health
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Viral Infections and Immunology Research
- Vascular Procedures and Complications
- Cardiac, Anesthesia and Surgical Outcomes
- Nitric Oxide and Endothelin Effects
- Infectious Diseases and Tuberculosis
- Blood Pressure and Hypertension Studies
- Heart Rate Variability and Autonomic Control
- Aortic aneurysm repair treatments
Aalborg University Hospital
2016-2025
Aalborg University
2016-2021
Cardiff University
2012-2017
Cardiff Metropolitan University
2016
University Hospital of Wales
2009-2015
Morriston Hospital
2015
The University of Texas Health Science Center at Houston
2015
Freeman Hospital
2012
University College London
2000
Boston University
1999
BackgroundRemote ischaemic conditioning with transient ischaemia and reperfusion applied to the arm has been shown reduce myocardial infarct size in patients ST-elevation infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). We investigated whether remote could incidence of cardiac death hospitalisation for heart failure at 12 months.MethodsWe did an international investigator-initiated, prospective, single-blind, randomised controlled trial (CONDI-2/ERIC-PPCI) 33...
Abstract Aims The aim of this study is to evaluate temporal trends, treatment, and clinical outcomes patients who present with an acute myocardial infarction (AMI) have a current or historical diagnosis cancer, according cancer type presence metastases. Methods results Data from 6 563 255 presenting AMI between 2004 2014 the US National Inpatient Sample (NIS) database were analysed. A total 5 966 955 had no 186 604 409 697 cancer. Prostate, breast, colon, lung four most common types Patients...
This research was performed to study the attitudes that medical students hold concerning their relationships with patients, and whether such are gender-related, affect career plans, influence evaluation of psycho-social biomedical issues.One hundred fifty-three first year at Boston University School Medicine completed Patient-Practitioner Orientation Scale (PPOS), a scale differentiates between patient-centered vs. doctor-centered orientation toward practice, indicated interest in community...
In patients with increased bleeding risk, the biolimus A9-coated BioFreedom stent, a stainless steel drug-coated stent free from polymer, has shown superiority compared bare-metal stent. The aim of this study was to investigate whether is noninferior modern ultrathin strut biodegradable polymer cobalt-chromium sirolimus-eluting Orsiro in an all-comers patient population treated percutaneous coronary intervention.The SORT OUT IX trial (Scandinavian Organization for Randomized Trials With...
Mechanical circulatory support (MCS) with either extracorporeal membrane oxygenation or Impella has shown potential as a salvage therapy for patients refractory out-of-hospital cardiac arrest (OHCA). The objective of this study was to describe the gradual implementation, survival and adherence national consensus respect use MCS OHCA in Denmark, identify factors associated outcome.This retrospective, observational cohort included receiving at all tertiary centers (n = 4) Denmark between July...
We report disease-specific cardiovascular causes of mortality among cancer patients in the USA between 1999 and 2019, considering temporal trends by age, sex, site.
Background: Target lesion failure remains an issue with contemporary drug-eluting stents. Thus, the dual-therapy sirolimus-eluting and CD34+ antibody–coated Combo stent (DTS) was designed to further improve early healing. This study aimed investigate whether DTS is noninferior Orsiro (SES) in all-comers patient population. Methods: The SORT OUT X (Combo Stent Versus Stent) trial, a large-scale, randomized, multicenter, single-blind, 2-arm, noninferiority trial registry-based follow-up....
While current evidence suggests that the clinical outcomes of ST-elevation myocardial infarction (STEMI) are worse among patients with cancer, it is unknown what role quality care received during admission plays. We aimed to evaluate association between and patient survival after discharge. A nationally-linked cohort STEMI (January 2005-March 2019) were obtained from UK Myocardial Infarction National Audit Project (MINAP) national Hospital Episode Statistics Admitted Patient Care (HES APC)...
The paper describes the investigation of 296 patients selected at random from those attending general practitioners9 surgery and studied by means multiple biochemical haematological tests. tests that would not normally have been requested led to a new diagnosis clinical significance in 16·9% patients, most instances requiring an alteration patient9s therapy. effect profile on patient follow-up, referral hospital, need for subsequent investigations was comparing profiled with control group...
We aimed to investigate major adverse cardiac events (MACE: defined as all-cause mortality, re-infarction, and stroke), length of hospital stays (LOS), comorbidities following acute coronary syndrome (ACS) in a population with schizophrenia.This Danish register study included patients diagnosed ACS the period between 1995 2013 preceding diagnosis schizophrenia (n = 726). Each patient was matched psychiatric healthy control 1:2 on sex, age, year diagnosis, number (total n 2178). After...
Objective Incidence and severity of acute myocarditis vary significantly in previous reports there is a lack epidemiological studies on the short-term risks mortality, heart failure ventricular arrhythmias patients with myocarditis. Therefore, study aims were to examine 90-day (HF) comparison age-matched sex-matched background population controls. Methods In this nationwide register-based follow-up hospitalised between 2002 2018 Denmark, all-cause HF, (ventricular tachycardia, fibrillation...
Background: Biodegradable polymer drug-eluting stents were developed to improve safety and efficacy outcomes for patients undergoing percutaneous coronary intervention. However, few long-term follow-up studies are available. The study sought investigate 5-year results from the SORT OUT VII trial (Scandinavian Organization Randomized Trials With Clinical Outcome) comparing biodegradable ultrathin-strut sirolimus-eluting Orsiro stent (O-SES) versus biolimus-eluting Nobori (N-BES). Methods:...
Background: For patients with high bleeding risk, the BioFreedom stent is safer and more effective than a bare metal stent.However, at one-year follow-up of SORT OUT IX trial, did not meet criteria for non-inferiority target lesion failure (TLF) when compared Orsiro had higher incidence revascularisation (TLR). Aims:The aim study was to compare two-year outcomes following coronary implantation or stents in all-comer patients. Methods:The Scandinavian Organization Randomized Trials Clinical...
Highlights•Out of over 20 million ED encounters with CVD, 3.4% were in patients cancer.•In cancer the most common CVDs was DVT/PE.•Patients presenting CVD at higher risk adverse outcomes.•Cancer associated mortality almost all categories.AbstractBackgroundthere is limited data on Emergency department (ED) cardiovascular disease (CVD) presentations and outcomes amongst patients.ObjectivesThe present study aimed to describe clinical characteristics, prevalence, admissions cancer.MethodsAll a...
Determine the real-world difference between 2 groups of patients with severe aortic stenosis and similar baseline comorbidities: surgical turn down (STD) patients, who were managed medically prior to availability transcatheter valve implantation (TAVI) following formal outpatient assessment, a TAVI implant.Retrospective cohort study from data.Electronic patient letters searched for diagnosis STD (1999-2009). The second group comprised first 90 cases in South Wales (2009 onwards). years 5...
Trials suggest patients with ST-elevation myocardial infarction (STEMI) without 'standard modifiable cardiovascular risk factors' (SMuRFs) have poorer outcomes, but the role of ethnicity has not been investigated. We analyzed 118,177 STEMI using Myocardial Ischaemia National Audit Project (MINAP) registry. Clinical characteristics and outcomes were hierarchical logistic regression models; ≥1 SMuRF (n = 88,055) compared 'SMuRFless' 30,122), subgroup analysis comparing White Ethnic minority...
To characterize and follow patients with ST-segment elevation myocardial infarction (STEMI) at high bleeding risk (HBR) according to the predicting complications in undergoing stent implantation subsequent dual antiplatelet therapy (PRECISE-DAPT) score, examine use of P2Y12 inhibitors major adverse cardiovascular events (MACE) bleeding.This single-centre cohort study included 6179 consecutive STEMI who underwent percutaneous coronary intervention (PCI) Copenhagen University Hospital,...
With increased use of transcatheter aortic valve implantation (TAVI) in treatment stenosis, it is important to evaluate real life data trends outcomes. This nationwide register-based study aimed present an outlook on temporal characteristics and outcomes, including mortality.First-time consecutive Danish patients who underwent TAVI from 2010 2019 were included this study.The chi-square Kruskal–Wallis tests performed assess the differences over time Cochrane–Armitage trend used examine...