A5006806421- Acute Ischemic Stroke Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Health Systems, Economic Evaluations, Quality of Life
- Schizophrenia research and treatment
- Atrial Fibrillation Management and Outcomes
- Stroke Rehabilitation and Recovery
- Music Therapy and Health
- Cardiac Arrest and Resuscitation
- Sleep and related disorders
- Cerebrovascular and Carotid Artery Diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Venous Thromboembolism Diagnosis and Management
- Cardiac Arrhythmias and Treatments
- Sleep and Wakefulness Research
- Bipolar Disorder and Treatment
- Cardiac Health and Mental Health
- Cancer survivorship and care
- Palliative Care and End-of-Life Issues
- Dementia and Cognitive Impairment Research
- Patient Satisfaction in Healthcare
- Cardiac Ischemia and Reperfusion
- Heart Failure Treatment and Management
- Chronic Disease Management Strategies
- Traumatic Brain Injury Research
- Emergency and Acute Care Studies
Aalborg University
2016-2025
Aalborg University Hospital
2015-2025
North Denmark Region
2020-2025
Moesgaard Museum
2024
Central Denmark Region
2024
Central University of the Caribbean
2024
Aarhus University Hospital
2023-2024
Regional Hospital Horsens
2023
Aarhus University
2023
Vejle Sygehus
2023
<h3>Importance</h3> The optimal blood pressure targets during endovascular therapy (EVT) for acute ischemic stroke (AIS) are unknown. <h3>Objective</h3> To study whether procedural parameters, including specific thresholds, associated with neurologic outcomes after EVT. <h3>Design, Setting, and Participants</h3> This retrospective cohort included adults anterior-circulation AIS who were enrolled in randomized clinical trials assessing anesthetic strategy EVT between February 2014 2017. had...
Importance Despite some promising preclinical and clinical data, it remains uncertain whether remote ischemic conditioning (RIC) with transient cycles of limb ischemia reperfusion is an effective treatment for acute stroke. Objective To evaluate the effect RIC when initiated in prehospital setting continued hospital on functional outcome patients Design, Setting, Participants This was a randomized trial conducted at 4 stroke centers Denmark that included 1500 symptoms less than hours...
Previous studies from local settings have reported that women with acute ischemic stroke a lower chance of receiving reperfusion therapy treatment, including intravenous thrombolysis and thrombectomy, than men, but the underlying mechanisms this disparity not been identified. We aimed to examine sex differences in utilization focusing on all phases pre- in-hospital time delay nationwide population-based cohort.This study was based data public registries. The population included patients aged...
Remote ischemic conditioning (RIC) is a simple and noninvasive procedure that has proved to be safe feasible in numerous smaller clinical trials. Mixed results have been found recent large randomized controlled This post hoc subgroup analysis of the RESIST trial (Remote Ischemic Conditioning Patients With Acute Stroke), investigating effect RIC different acute stroke etiologies, whether an was modified by treatment adherence.
Background Quality indicators are used to quantify the quality of care. A large number makes assessment overall difficult, time consuming and impractical. There is consequently an increasing interest for composite measures based on a combination multiple indicators. Objective To examine use different approaches construct care assess methodological considerations justifications. Methods We conducted literature search PubMed EMBASE databases (latest update 1 December 2020). For each...
Abstract Background A high concentration of inspired supplemental oxygen may possibly cause hypercapnia and acidosis increase mortality in patients with acute exacerbation chronic obstructive pulmonary disease (AECOPD). Even so, AECOPD are being treated flow rates when receiving inhalation drugs the prehospital setting. cluster-randomised controlled trial found that reduced delivery by titrated treatment mortality—a result supported observational studies—but results have never been...
Background: It remains uncertain whether remote ischemic conditioning (RIC) with transient cycles of limb ischemia and reperfusion is an effective supplement to standard-of-care management intracerebral hemorrhage (ICH) Objective: To evaluate RIC can reduce hematoma expansion peri-hematoma edema in patients ICH. Design, Setting Participants: This a predefined substudy randomized clinical trial conducted at four stroke centers Denmark. Among the subset participants ICH, brain imaging was...
Monitoring quality of healthcare is vital to ensure that changes made clinical practice achieve the intended goals. Assessing temporal trends due accumulated effect all in a given period essential monitoring. However, this assesment compplicated by fact numerous might occour over time unrelated practice. Furthermore, methods used assess patient outcomes medical literature are heterogeneous, making it difficult compare results between studies. In paper, we describe enable researchers...
Rises in prevalence and incidence of the neurodevelopmental disorder Attention-deficit/Hyperactivity Disorder (ADHD) have been reported globally estimated Denmark previously. Nevertheless, differences methodology hinder an assessment temporal evolution ADHD based on published literature. The aim this study was to consistently calculate yearly proportions use medication from 2000 2022. We conducted open cohort using register data covering entire Danish population. defined as either having a...
Objective: To compare in a generalizable sample/setting objective outcomes patients receiving first-generation antipsychotic long-acting injectables (FGA-LAIs) or risperidone-LAI (RIS-LAI). Methods: Nationwide, retrospective inception cohort study of adults with International Classification Diseases-10 schizophrenia using Danish registers from 1995 to 2009 comparing between clinician's/patient's choice treatment FGA-LAIs RIS-LAI. Primary outcome was time psychiatric hospitalization...
To investigate psychiatric outcomes after bariatric surgery, including suicide, self-harm, service use and substance misuse.Retrospective study on a Danish nationwide register-based cohort of 22 451 patients followed for 1 029 736 person-years. Data were analysed utilizing single- multi-event Cox regression with non-operated controls obesity mirror-image analyses the operated patient serving as their own controls.We showed an increased ratio self-harm (hazard [HR] 3.23, P < 0.001; incidence...
Rapid identification and treatment of stroke is crucial for the outcome patient. We aimed to determine performance glial fibrillary acidic protein (GFAP) independently in combination with Prehospital Stroke Score (PreSS) differentiation acute within 4.5 h after symptom onset. Clinical data serum samples were collected from Treat-Norwegian Acute Project (Treat-NASPP). Patients suspected symptoms lasting ≤ had blood evaluated National Institutes Health Scale prospectively. In this sub study,...
We present a new software framework for Markov chain Monte Carlo sampling simulation, prediction, and inference of protein structure. The package contains implementations recent advances in methodology, such as efficient local updates from probabilistic models These form alternative to the widely used fragment rotamer libraries. Combined with an easily extendible architecture, this makes PHAISTOS well suited Bayesian structure sequence and/or experimental data. Currently, two force‐fields...
Remote ischaemic conditioning, applied in the prehospital setting and continued in-hospital, may improve functional outcome patients with acute stroke intracerebral haemorrhage.To evaluate whether combined remote per- postconditioning can long-term haemorrhage patients.Danish multicentre, prospective, randomised, patient-assessor blinded, sham-controlled study. Adult a putative identified symptom duration <4 h, who are independent daily activities will be randomised 1:1 to conditioning or...
When patients with acute ischemic stroke present suspected large vessel occlusion in the catchment area of a primary center (PSC), benefit direct transport to comprehensive (CSC) has been suggested. Equipoise remains between strategies and best strategy is not well established.
Background A correlation between excess mortality from myocardial infarctions (MI) and schizophrenia has already been established. What remains unclear is whether the initial communication treating doctor corresponding patient contributes to this mortality. Aim The aim of study investigate a with receives same offers for examination treatment following MI compared psychiatric healthy control (PHC). Methods This cohort includes patients diagnosed at time their first (n = 47) in years...
Ample studies have demonstrated that internet-based cognitive behavioural therapy (iCBT) for anxiety disorders is effective and acceptable in controlled settings. Studies assessing the clinical effectiveness of iCBT among routine care populations are, however, not as numerous. The purpose this study was to assess patients, who were on a waiting list intensive outpatient treatment, specialised clinic. A randomised pilot trial conducted. Recruited patients had primary diagnosis either social...