A5054885099- Acute Ischemic Stroke Management
- Advanced MRI Techniques and Applications
- Cardiac Ischemia and Reperfusion
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Intracerebral and Subarachnoid Hemorrhage Research
- Anesthesia and Neurotoxicity Research
- Neurological Disease Mechanisms and Treatments
- Cardiac Arrest and Resuscitation
- Intracranial Aneurysms: Treatment and Complications
- Neurological Disorders and Treatments
- MRI in cancer diagnosis
- Venous Thromboembolism Diagnosis and Management
- Neurosurgical Procedures and Complications
- Statistical Methods and Inference
- Cancer-related gene regulation
- Bayesian Modeling and Causal Inference
- Abdominal vascular conditions and treatments
- Bayesian Methods and Mixture Models
- Aortic aneurysm repair treatments
- Restless Legs Syndrome Research
- Lanthanide and Transition Metal Complexes
- Clinical practice guidelines implementation
- Parkinson's Disease Mechanisms and Treatments
Aarhus University Hospital
2015-2025
Aarhus University
2013-2024
Bayer (Germany)
2024
Dansk Sygehus Institut
2006
University of Oslo
1996
Background and Purpose— Remote ischemic preconditioning is neuroprotective in models of acute cerebral ischemia. We tested the effect prehospital rPerC as an adjunct to treatment with intravenous alteplase patients stroke. Methods— Open-label blinded outcome proof-of-concept study prehospital, paramedic-administered at a 1:1 ratio consecutive suspected After neurological examination MRI, verified stroke receiving were included received MRI 24 hours 1 month clinical re-examination after 3...
Importance Despite some promising preclinical and clinical data, it remains uncertain whether remote ischemic conditioning (RIC) with transient cycles of limb ischemia reperfusion is an effective treatment for acute stroke. Objective To evaluate the effect RIC when initiated in prehospital setting continued hospital on functional outcome patients Design, Setting, Participants This was a randomized trial conducted at 4 stroke centers Denmark that included 1500 symptoms less than hours...
Remote ischemic conditioning (RIC) is a simple and noninvasive procedure that has proved to be safe feasible in numerous smaller clinical trials. Mixed results have been found recent large randomized controlled This post hoc subgroup analysis of the RESIST trial (Remote Ischemic Conditioning Patients With Acute Stroke), investigating effect RIC different acute stroke etiologies, whether an was modified by treatment adherence.
Abstract Most Parkinson's patients complain about sleep problems. The subjective effect of deep brain stimulation (DBS) the subthalamic nucleus (STN) on nocturnal disabilities and quality was elucidated by recently established disease scale (PDSS). DBS‐treated group obtained significant improvement motor function assessed Unified Disease Rating Scale. mean total PDSS improved significantly after surgery whereas no change found for control group. Significant improvements individual questions...
Background: It remains uncertain whether remote ischemic conditioning (RIC) with transient cycles of limb ischemia and reperfusion is an effective supplement to standard-of-care management intracerebral hemorrhage (ICH) Objective: To evaluate RIC can reduce hematoma expansion peri-hematoma edema in patients ICH. Design, Setting Participants: This a predefined substudy randomized clinical trial conducted at four stroke centers Denmark. Among the subset participants ICH, brain imaging was...
Cerebral ischemia causes widespread capillary no-flow in animal studies. The extent of microvascular impairment human stroke, however, is unclear. We examined how acute intra-voxel transit time characteristics and subsequent recanalization affect tissue outcome on follow-up MRI a historic cohort 126 ischemic stroke patients. Based perfusion-weighted data, we characterized voxel-wise times terms their mean (MTT), standard deviation (capillary heterogeneity – CTH), the CTH:MTT ratio (relative...
Remote ischaemic conditioning, applied in the prehospital setting and continued in-hospital, may improve functional outcome patients with acute stroke intracerebral haemorrhage.To evaluate whether combined remote per- postconditioning can long-term haemorrhage patients.Danish multicentre, prospective, randomised, patient-assessor blinded, sham-controlled study. Adult a putative identified symptom duration <4 h, who are independent daily activities will be randomised 1:1 to conditioning or...
When patients with acute ischemic stroke present suspected large vessel occlusion in the catchment area of a primary center (PSC), benefit direct transport to comprehensive (CSC) has been suggested. Equipoise remains between strategies and best strategy is not well established.
Abstract Purpose To investigate the potential of novel postprocessing and visualization techniques to distinguish presence collateral flow using Bolus Tracking MRI. Collateral blood supply is believed be paramount importance in acute stroke, yet clinical evaluation challenging as gold standard digital subtraction angiography often not feasible scenario. Materials Methods In principle, bolus arrival delay data contains information about route into tissue hereby patterns. We first examined...
Abstract Background Neurofilament light chain (NfL) is a neuron-specific biomarker with prognostic ability in several types of central nervous system injuries. This study investigates if plasma NfL (pNfL) elevated early after spontaneous intracerebral hemorrhage (ICH) and whether such elevation reflects disease severity day-30 outcome. Methods pNfL was quantified by single molecule array analysis 103 reference subjects (RS) samples from 37 patients ICH obtained on admission to hospital at...
Background Intravenous administration of alteplase is the only approved treatment for acute ischemic stroke. Despite effectiveness this treatment, 50% patients suffer chronic neurological disability, which may in part be caused by ischemia-reperfusion injury. Remote perconditioning, performed as a transient stimulus blood-pressure cuff inflation to an extremity, has proven effective attenuating injury animal models perconditioning increases myocardial salvage undergoing revascularization...
This secondary analysis of a randomized clinical trial assesses whether compliance with the study protocol is associated better functional outcome even among participants in sham-control group.
Vertebral artery (VA) dissection (VAD) has been described following neck injury and can be associated with stroke, but the causal association cervical spine manipulation therapy (cSMT) is controversial. The standard treatment for VAD antithrombotic medical therapy. To highlight considerations of an endovascular approach to VAD, we present a critical case bilateral causing embolic occlusion basilar (BA) in patient symptom debut cSMT.A 37-year-old woman presented acute onset neurological...
Background and Purpose: Delayed recanalization increases the risk of infarct growth poor clinical outcome in acute ischemic stroke. The vasoactive agent theophylline has shown neuroprotective effects animal stroke models but inconclusive results case series randomized trials. primary objective this study was to evaluate whether theophylline, as an add-on thrombolytic therapy, is safe effective patients. Methods: TEA-Stroke trial (The Theophylline Acute Ischemic Stroke) investigator-initiated...
Introduction Early reperfusion of brain tissue at risk injury (penumbra salvage) is crucial in treating acute ischaemic stroke. Neuroprotective agents may extend the time window for reperfusion. The vasoactive agent theophylline redistributes perfusion to and thus reduces damage, oedema mortality animal stroke models. Furthermore, treatment with has been shown result considerable rapid clinical improvement, albeit only temporary, some patients. We hypothesize that will improve collateral...
Objective: To examine the agreement between emergency medical service (EMS) providers, neurology residents and consultants, using Cincinnati Prehospital Stroke Scale (CPSS) Acute Severity (PASS). Methods: Patients with stroke, transient ischemic attack (TIA) stroke mimic were included upon primary admission or during rehabilitation. from June 2018 to September 2019. Video recordings made of patients being assessed CPSS PASS. The later presented healthcare professionals. determine relative...
Background and Purpose: The theophylline in acute ischemic stroke trial investigated the neuroprotective effect of as an add-on to thrombolytic therapy patients with stroke. aim this pre-planned subgroup analysis was use predictive modeling virtually test for differences follow-up lesion volumes. Materials Methods: A 52 from multi-parametric MRI data acquired at baseline 24-h were analyzed. machine learning model using voxel-by-voxel information diffusion- perfusion-weighted clinical...
Introduction: Remote ischemic conditioning (RIC) is a simple and non-invasive procedure that has proved safe feasible in numerous smaller clinical trials. Still, mixed results have been found recent large randomized controlled Here we present predefined subgroup analysis of the RESIST trial on effect RIC subgroups acute stroke (AIS) whether this modified by adherence to RIC. Methods: The were defined as artery atherosclerotic disease (LAA), small vessel (SVD), cardioembolic,...
Hypertension and cerebral amyloid angiopathy are the most common causes of spontaneous intracerebral hemorrhage (ICH); however, these conditions do not imply macrovascular pathology. Still, computed tomography (CT) angiography (CTA) is often performed in acute phase patients with ICH.