A5006486320- Acute Ischemic Stroke Management
- Stroke Rehabilitation and Recovery
- Cerebrovascular and Carotid Artery Diseases
- Visual perception and processing mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Venous Thromboembolism Diagnosis and Management
- Cardiac Ischemia and Reperfusion
- Dementia and Cognitive Impairment Research
- Spatial Cognition and Navigation
- Intracranial Aneurysms: Treatment and Complications
- Botulinum Toxin and Related Neurological Disorders
- Neurological Disorders and Treatments
- Visual Attention and Saliency Detection
- Cardiac Health and Mental Health
- Anesthesia and Neurotoxicity Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Cardiovascular and Diving-Related Complications
- Advanced MRI Techniques and Applications
- Atrial Fibrillation Management and Outcomes
- Healthcare Systems and Practices
- Neurological Disease Mechanisms and Treatments
- Pain Mechanisms and Treatments
- Ophthalmology and Visual Impairment Studies
- Cardiac Arrest and Resuscitation
- Epilepsy research and treatment
Aarhus University Hospital
2016-2025
Aarhus University
2015-2025
Danish Pain Research Center
2001-2025
Health and Education Research Management and Epidemiologic Services (United States)
2023
European Stroke Organisation
2023
University of Copenhagen
2018-2021
Aalborg University
1995-2021
Rigshospitalet
2008-2021
Andersen (United States)
2013-2020
Charité - Universitätsmedizin Berlin
2019
Under current guidelines, intravenous thrombolysis is used to treat acute stroke only if it can be ascertained that the time since onset of symptoms was less than 4.5 hours. We sought determine whether patients with an unknown and features suggesting recent cerebral infarction on magnetic resonance imaging (MRI) would benefit from use alteplase.
The efficacy of closure a patent foramen ovale (PFO) in the prevention recurrent stroke after cryptogenic is uncertain. We investigated effect PFO combined with antiplatelet therapy versus alone on risks and new brain infarctions.In this multinational trial involving patients who had stroke, we randomly assigned patients, 2:1 ratio, to undergo plus (PFO group) or receive (antiplatelet-only group). Imaging was performed at baseline screening 24 months. coprimary end points were freedom from...
The options for secondary prevention of cryptogenic embolism in patients with patent foramen ovale are administration antithrombotic medications or percutaneous closure the ovale. We investigated whether is superior to medical therapy.
Central post-stroke pain (CPSP) is a neuropathic syndrome characterized by constant or intermittent in body part occurring after stroke and associated with sensory abnormalities the painful part. This study describes CPSP prospectively during first year characterizes cerebrovascular lesions neurological signs syndrome. Two hundred sixty-seven consecutively admitted patients younger than 81 years were examined week, at 1, 6 12 months stroke. Sensibility to touch (cotton wool), temperature (20...
The aim of the study was to investigate efficacy and safety selective serotonin reuptake inhibitor citalopram in treating poststroke depression, since available treatments are usually poorly tolerated. A 6-week double-blind, placebo-controlled trial undertaken. Diagnosis outcome were determined using Hamilton Depression Scale, unwanted effects measured UKU side effect rating scale. Sixty-six consecutive depressed patients from an unselected population 285 stroke aged 25 80 years entered 2 52...
Endovascular therapy (EVT) is the standard of care for select patients who had a stroke caused by large vessel occlusion in anterior circulation, but there uncertainty regarding optimal anesthetic approach during EVT. Observational studies suggest that general anesthesia (GA) associated with worse outcomes compared conscious sedation (CS).To examine effect type EVT on infarct growth and clinical outcome.The General or Local Anesthesia Intra Arterial Therapy (GOLIATH) trial was single-center...
Background and Purpose— Remote ischemic preconditioning is neuroprotective in models of acute cerebral ischemia. We tested the effect prehospital rPerC as an adjunct to treatment with intravenous alteplase patients stroke. Methods— Open-label blinded outcome proof-of-concept study prehospital, paramedic-administered at a 1:1 ratio consecutive suspected After neurological examination MRI, verified stroke receiving were included received MRI 24 hours 1 month clinical re-examination after 3...
The relationship between in-hospital stroke-related medical complications and clinical outcome remains unclear. We examined whether were associated with length of stay (LOS) mortality among stroke unit patients.Using population-based Danish registries, we performed a follow-up study all patients acute admitted to units in 2 counties 2003 2009 (n=13 721). Data regarding complications, including pneumonia, urinary tract infection, pressure ulcer, falls, deep venous thrombosis, pulmonary...
We designed and validated a simple prehospital stroke scale to identify emergent large vessel occlusion (ELVO) in patients with acute ischemic compared the other published scales for prediction of ELVO.A national historical test cohort 3127 information on intracranial status (angiography) before reperfusion therapy was identified. National Institutes Health Stroke Scale (NIHSS) items highest predictive value artery were identified, most optimal combination meeting predefined criteria ensure...
The purpose of the European Stroke Organisation–Karolinska Update Conference is to provide updates on recent stroke therapy research and give an opportunity for participants discuss how these results may be implemented into clinical routine. meeting started 22 years ago as Karolinska Update, but since 2014 it a joint conference with Organisation. Importantly, provides platform discussion Organisation guidelines process recommendations committee specific topics. By this, adds direct influence...
It is generally believed that opioids relieve neuropathic pain less effectively than nociceptive and they have no effect on some of the key characteristics such as touch-evoked (allodynia). Tramadol an analgesic drug acting directly opioid receptors indirectly monoaminergic receptor systems. The aim this trial was to determine whether tramadol relieved painful polyneuropathy reduced allodynia. study design randomised, double-blind, placebo-controlled cross-over. After baseline observations,...
<b><i>Objective:</i></b> Central poststroke pain (CPSP) is usually difficult to treat. Amitriptyline, the only oral preparation shown be effective in a randomized controlled trial, often associated with range of side effects related many mechanisms actions tricyclic antidepressants. We investigated effect lamotrigine, drug that reduces neuronal hyperexcitability, on pain. <b><i>Methods:</i></b> Thirty consecutive patients CPSP (median age 59 years, 37 77; median duration 2.0 0.3 12) from two...
An unselected cohort of 285 stroke patients, median age 69 years, were studied for correlation between potential risk factors and the 1‐year incidence post‐stroke depression (PSD). The following correlated significantly with PSD: a history previous stroke, depression, female gender, living alone social distress prestroke. Further, inactivity, decrease in activity, pathological crying intellectual impairment at 1 month but not functional outcome to PSD. A multivariate regression analysis...
Background and Purpose —The penumbra of ischemic stroke consists hypoperfused, but not irreversibly damaged, tissue surrounding the core. The purpose this study was to determine viability thresholds in penumbra, defined as perfusion/diffusion mismatch hyperacute stroke, by use diffusion- perfusion-weighted MRI (DWI PWI, respectively). Methods —DWI PWI were performed 11 patients ≤6 hours after onset symptoms acute stroke. Regions interest (ROIs) placed covering core (ROI 1), that progressed...
<b>Objective</b> To assess effect of age on response to alteplase in acute ischaemic stroke. <b>Design</b> Adjusted controlled comparison outcomes between non-randomised patients who did or not undergo thrombolysis. Analysis used Cochran-Mantel-Haenszel test and proportional odds logistic regression analysis. <b>Setting</b> Collaboration International Stroke Thrombolysis Registry (SITS-ISTR) Virtual Trials Archive (VISTA). <b>Participants</b> 23 334 from SITS-ISTR (December 2002 November...
This study examined the sensory abnormalities in an unselected, consecutive group of patients with central post-stroke pain (CPSP) surviving more than 1 year after stroke. The examination included clinical and quantitative measures detection thresholds to heat cold stimuli, argon laser, von Frey hair determination stimulus-response function 10-45 degrees C range. Sensory was 11 identified CPSP (5 female, 6 male; aged 43-80 years) carried out painful area using contralateral homologue as...
Abstract Background Post‐stroke pain is common and affects the quality of life stroke survivors, but incidence severity headache, shoulder pain, other joint central post‐stroke following still remain unclear. The aim this prospective study was to determine intensity these different types pain. Methods A total 299 consecutive patients, admitted D epartment N eurology at arhus U niversity H ospital, underwent a structured interview short sensory examination within 4 days admission. Follow‐up...
<i>Background:</i> The aim of this study was to examine the course poststroke fatigue in a cohort first-time stroke patients compared general population, and identify clinically relevant features post-stroke fatigue. <i>Methods:</i> We performed follow-up 165 with admitted acute units at Aarhus University Hospital, Denmark. A reference group 1,069 persons sampled from population. Fatigue assessed using Multidimensional Inventory (MFI-20) covering five scales (General...
This paper is based on a workshop held in Oslo, Norway November 2013, which experts discussed how to reach consensus the healthiness of red and processed meat. Recent nutritional recommendations include reducing intake meat reduce cancer risk, particular colorectal (CRC). Epidemiological mechanistic data associations between CRC are inconsistent underlying mechanisms unclear. There need for further studies differences white meat, whole different types meats, as potential health risks may not...
Central poststroke pain (CPSP) is a specific condition arising as direct consequence of cerebrovascular lesion. There limited knowledge about the epidemiology and clinical characteristics this often neglected but important stroke. In population-based study, questionnaire was sent out to all (n = 964) stroke patients identified through Danish National Indicator Project Stroke Database in Aarhus County, Denmark, between March 2004 February 2005. All surviving who fulfilled 4 criteria for...
Andersen G, Christensen D, Kirkevold M, Johnsen SP. Post-stroke fatigue and return to work: a 2-year follow-up. Acta Neurol Scand: 2012: 125: 248–253. © 2011 John Wiley & Sons A/S. Background – may affect the ability work but quantitative studies are lacking. Method We included 83 first-ever stroke patients <60 years employed either full-time (n = 77) or part-time 6) at baseline. The were recruited from units Aarhus University Hospital between 2003 2005 followed for 2 years. Fatigue was...