A5085675426- Nutritional Studies and Diet
- Meat and Animal Product Quality
- Advanced Chemical Sensor Technologies
- Bacterial Genetics and Biotechnology
- Dye analysis and toxicity
- Bacillus and Francisella bacterial research
- Carcinogens and Genotoxicity Assessment
- Diet and metabolism studies
- Culinary Culture and Tourism
- Animal Nutrition and Physiology
- Pharmacological Effects and Assays
- Effects and risks of endocrine disrupting chemicals
- Adipose Tissue and Metabolism
- Cancer Cells and Metastasis
- Tea Polyphenols and Effects
- Microbial Inactivation Methods
- Cancer, Lipids, and Metabolism
- Gastric Cancer Management and Outcomes
- Toxic Organic Pollutants Impact
- Wnt/β-catenin signaling in development and cancer
- Molecular Biology Techniques and Applications
- Cancer Research and Treatments
- Antibiotic Resistance in Bacteria
- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
Norwegian Veterinary Institute
2018-2024
Animalia (Norway)
2018-2024
Norwegian University of Life Sciences
2010-2018
Norwegian Food Safety Authority
2017
University of Oslo
2012
This paper is based on a workshop held in Oslo, Norway November 2013, which experts discussed how to reach consensus the healthiness of red and processed meat. Recent nutritional recommendations include reducing intake meat reduce cancer risk, particular colorectal (CRC). Epidemiological mechanistic data associations between CRC are inconsistent underlying mechanisms unclear. There need for further studies differences white meat, whole different types meats, as potential health risks may not...
This study focuses on the interaction of three components Bacillus cereus Nhe enterotoxin with particular emphasis functional roles NheB and NheC. The results demonstrated that both NheC were able to bind Vero cells directly while NheA lacked this ability. It was also shown Nhe-induced cytotoxicity required a specific binding order individual whereby presence in priming step as well final incubation mandatory. Priming alone addition plus second failed induce toxic effects. Furthermore,...
Male piglets are surgically castrated at a young age primarily to prevent pork meat from being tainted with boar taint, an offensive taste and odor that can be present in uncastrated male pigs. The practice of surgical castration is considered both stressful painful for the piglets, therefore under scrutiny due animal welfare concerns. Rearing intact males or vaccination against taint (immunocastration) two potential alternatives castration, but order successfully implement either these...
Transcriptional profiling highlighted a subset of genes encoding putative multidrug transporters in the pathogen Bacillus cereus that were up-regulated during stress produced by bile salts. One these (BC4707) was selected for investigation. Functional characterization BC4707 protein Escherichia coli revealed role energized efflux xenobiotics. Phenotypic analyses after inactivation gene bc4707 ATCC14579 suggested more specific, but modest norfloxacin. In addition to this, transcriptional...
Red and processed meats are considered risk factors for colorectal cancer (CRC); however, the underlying mechanisms still unclear. One cause potential link between CRC meat is heme iron in red meat. Two pathways by which promotion may be linked have been suggested: fat peroxidation N-nitrosation. In present work we used novel A/J Min/+ mouse model to test effects of dietary hemin (a meat), combination with nitrite meat) on intestinal tumorigenesis. Mice were fed a low Ca2+ vitamin D...
The C57BL/6J multiple intestinal neoplasia (Min/+) mouse is a widely used murine model for familial adenomatous polyposis, hereditary form of human colorectal cancer. However, it questionable partly because the vast majority tumors arise in small intestine, and fraction that progress to invasive carcinomas minuscule. A/J mice are typically more susceptible carcinogen-induced cancer than mice. To investigate whether novel Min/+ on genetic background could be better cancer, we examined...
The Meat Factory Cell (MFC) concept restructures the slaughter line into cell stations and merges elements of slaughter- primal cutting processes. With MFC approach, most primals are removed prior to evisceration. This study describes effect on carcass hygiene, yield, meat quality traits, sensory characteristics selected products from trials with very first pig carcasses processed approach. Results show that hygiene rivals conventionally slaughtered carcasses. For variables products, shows...
A multitude of cancer types, including breast, testicular, liver and colorectal cancer, have associations with exposure to Persistent Organic Pollutants (POPs). The present study aimed investigate whether a mixture POPs could affect intestinal tumorigenesis in the A/J Min/+ mouse, model for human (CRC). were selected their presence Scandinavian food products was designed based on defined estimated daily intake levels. Mice exposed through diet, at control, low high concentrations, 10 weeks....
The International Agency for Research on Cancer has classified red meat as "probably carcinogenic to humans" (Group 2A). In mechanistic studies exploring the link between intake of and CRC, heme iron, pigment meat, is proposed play a central role catalyzer luminal lipid peroxidation cytotoxicity. present work, novel A/J Min/+ mouse was used investigate effects dietary beef, pork, chicken, or salmon (40% muscle food (dry weight) 60% powder diet) Apc-driven intestinal carcinogenesis, from week...
Intake of red meat is considered a risk factor for colorectal cancer (CRC) development, and heme, the prosthetic group myoglobin, has been suggested as potential cause. One proposed molecular mechanisms heme-induced CRC based on an increase in rate lipid peroxidation catalysed by heme.In present work, novel A/J Min/+ mouse model Apc-driven was used to investigate effect dietary heme (0.5 μmol/g), combined with high (40 energy %) or low (10 fat levels, intestinal carcinogenesis. At end...
Background: Colorectal cancer (CRC) is one of the most common types worldwide. The role intestinal microbiota in CRC, however, not well established. In particular, co-variation between age, tumor progression and remains largely unknown. Objective design: We therefore used a recently developed A/J Min/+ mouse model resembling human CRC to investigate how microbial composition cecum correlates with progression, butyrate age. Results: found that association gut load was stronger, by far, than...
With heritable PSE (hal+) being largely eradicated in many countries, pork quality defects and their linkage to known mutations have received less attention the last decade. We address this by mapping frequency of four (200Q, 199 V, hal+, PHKG1) heterogenous Norwegian German pig populations (n = 136/61). Genotyping for was done PCR-RFLP analyses Illumina chip genotyping. found a high prevalence pigs with at least one tested samples (60%, 77%). For samples, we confirm links 200Q PHKG1...
This work presents the use of low-power microwave sensors for detection two boar taint compounds, skatole and androstenone. These compounds are associated with malodour from entire male pigs, which has been a long-running challenge meat industry. A resonant cavity-based sensor is used to demonstrate selectivity, limits androstenone at 7.1 41.4 ppm respectively, where both were dissolved individually in ethanol acetonitrile. The considered step toward using this technique on- or at-line...