A5100754601- Neuropeptides and Animal Physiology
- Helicobacter pylori-related gastroenterology studies
- Neuroendocrine Tumor Research Advances
- Regulation of Appetite and Obesity
- Diet and metabolism studies
- Cancer, Stress, Anesthesia, and Immune Response
- Biochemical Analysis and Sensing Techniques
- Pancreatic function and diabetes
- Polyamine Metabolism and Applications
- Bariatric Surgery and Outcomes
- Gastrointestinal motility and disorders
- Diabetes Treatment and Management
- Receptor Mechanisms and Signaling
- Amino Acid Enzymes and Metabolism
- Pancreatic and Hepatic Oncology Research
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Adipose Tissue and Metabolism
- Digestive system and related health
- Ion Transport and Channel Regulation
- Mast cells and histamine
- Gastroesophageal reflux and treatments
- Adenosine and Purinergic Signaling
- Epigenetics and DNA Methylation
- Caveolin-1 and cellular processes
Norwegian University of Science and Technology
2016-2025
Jinan University
2022-2024
China Three Gorges University
2023-2024
St Olav's University Hospital
2001-2017
Central Norway Regional Health Authority
2017
The Ohio State University
2012
Sichuan University
2012
Tufts Medical Center
2003
Lund University
1991-2001
NTNU Samfunnsforskning
2000
Surgical or pharmacologic interruption of muscarinic innervation to the stomach suppresses gastric tumor growth in mice and humans.
Trefoil factor family 2 (TFF2), also known as spasmolytic polypeptide, is a member of the trefoil peptides and expressed primarily in mucous neck cells gastric mucosa. To study physiologic role TFF2, we have generated TFF2-deficient mice through targeted gene disruption. Homozygous mutant were viable fertile without obvious gastrointestinal abnormalities. However, quantitative measurements revealed significant decrease mucosal thickness proliferation rates. In addition, there was twofold...
This paper is based on a workshop held in Oslo, Norway November 2013, which experts discussed how to reach consensus the healthiness of red and processed meat. Recent nutritional recommendations include reducing intake meat reduce cancer risk, particular colorectal (CRC). Epidemiological mechanistic data associations between CRC are inconsistent underlying mechanisms unclear. There need for further studies differences white meat, whole different types meats, as potential health risks may not...
CD11b(+)Gr-1(+) myeloid-derived suppressor cells (MDSCs) expand in the spleen during cancer and promote progression through suppression of cytotoxic T cells. An anti-inflammatory reflex arc involving vagus nerve memory is necessary for resolution acute inflammation. Failure this neural circuit could procarcinogenic inflammation altered tumour immunity. Here we show that splenic TFF2, a secreted peptide, released by vagally modulated to suppress expansion MDSCs CXCR4. Splenic denervation...
Abstract Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, with a five-year survival rate 10–15% due to late-stage diagnosis and limited efficacy existing treatments. This study utilized proteomics-based systems modelling generate multimodal datasets from various research models, including PDAC cells, spheroids, organoids, tissues derived murine human samples. Identical mass spectrometry-based proteomics was applied across different models. The preparation...
Roux-en-Y gastric bypass (RYGB) is a weight-reduction procedure resulting in rapid resolution of type 2 diabetes (T2D). The role pancreatic islet function this restoration normoglycemia has not been fully elucidated. Using the diabetic Goto-Kakizaki (GK) rat model, we demonstrate that RYGB restores normal glucose regulation glucagon and insulin secretion normalizes morphology. Culture isolated islets with serum from animals mimicked these effects, implicating humoral factor. These latter...
This study characterizes the contribution of bone marrow-derived cells (BMDCs) to Barrett's adenocarcinoma esophagus using a mouse surgical model disease and human specimens. Transplantation marrow expressing beta galactosidase into wild-type mouse, followed by esophagojejunostomy, allowed tracking BMDCs anastomosis resulting metaplasia. Human tissue from male patient who had been transplanted with female later developed esophageal us tract donor-derived tumor. Using combination antibodies...
A recent study reported that a special weekly scheduled time-restricted feeding regimen (TRF), i.e., no food consumption for 15h during the light (inactive) phase per day 5 weekdays, attenuated outcome of diverse nutritional challenges in response to high-fat diet mice. In present study, we wanted further test whether this TRF could restrict body weight gain both juvenile and adult animals when fed diet. Fifty male Sprague-Dawley rats at ages from 27weeks were used. First, found freely with...
Background & AimsEnterochromaffin-like (ECL) cells in the stomach express gastrin/cholecystokinin 2 receptor CCK2R and are known to expand under hypergastrinemia, but whether this results from expansion of existing ECL or increased production progenitors has not been clarified.MethodsWe used mice with green fluorescent protein reporter expression (histidine decarboxylase [Hdc]-green protein), as well Cck2r- Hdc-driven Tamoxifen inducible recombinase Cre (Cck2r-CreERT2, Hdc-CreERT2) combined...
Knowledge discovery in databases (KDD) can contribute to translational research, also known as medicine, by bridging the gap between vitro and vivo studies clinical applications. Here, we propose a 'systems modeling' workflow for KDD. This framework includes data collection of composition model (various research models) processing (proteomics) analytical (bioinformatics, artificial intelligence/machine leaning pattern evaluation), knowledge presentation, feedback loops hypothesis generation...
A recent study of a mouse model prostate cancer uncovers mechanistic underpinning the epidemiologic link between use beta-blockers and reduced risk cancer.