A5051130162- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Urticaria and Related Conditions
- Vitamin K Research Studies
- Autoimmune Bullous Skin Diseases
- Chronic Myeloid Leukemia Treatments
- Mast cells and histamine
- Renin-Angiotensin System Studies
- Cardiovascular and Diving-Related Complications
- Blood Coagulation and Thrombosis Mechanisms
- Stroke Rehabilitation and Recovery
- Streptococcal Infections and Treatments
- Eicosanoids and Hypertension Pharmacology
- Tracheal and airway disorders
- Infectious Diseases and Tuberculosis
- Traumatic Brain Injury and Neurovascular Disturbances
- Neonatal Health and Biochemistry
- Head and Neck Cancer Studies
- Attention Deficit Hyperactivity Disorder
- Hemophilia Treatment and Research
- Otolaryngology and Infectious Diseases
- Mind wandering and attention
- Peptidase Inhibition and Analysis
- Restraint-Related Deaths
- Methemoglobinemia and Tumor Lysis Syndrome
- Cancer Diagnosis and Treatment
Technical University of Munich
2010-2018
Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia
2018
Klinikum rechts der Isar
2010-2014
Klinik und Poliklinik für Hals-, Nasen-, Ohrenheilkunde
2010
Düsseldorf University Hospital
2005-2006
Heinrich Heine University Düsseldorf
2005-2006
Universitäts-HNO-Klinik Heidelberg
2004
Angioedema is defined as localized and self-limiting edema of the subcutaneous submucosal tissue, due to a temporary increase in vascular permeability caused by release vasoactive mediator(s). When angioedema recurs without significant wheals, patient should be diagnosed have distinct disease. In absence accepted classification, different types are not uniquely identified. For this reason, European Academy Allergy Clinical Immunology gave its patronage consensus conference aimed at...
<h2>Abstract</h2><h3>Background</h3> Hereditary angioedema due to C1 inhibitor deficiency (C1-INH-HAE) causes swelling in the skin and upper airways pain abdomen because of mucosal swelling. C1-INH-HAE is frequently misdiagnosed, leading delays diagnosis, inadequate treatment, unnecessary procedures. <h3>Objective</h3> To evaluate history misdiagnosis patients participating Icatibant Outcome Survey (IOS). <h3>Methods</h3> The IOS an observational study which safety effectiveness icatibant...
Objectives: Analysis of pre-operative tracheostomy and circumjacent tumour free margins as risk factors in the development stomal recurrent disease after (pharyngo)laryngectomy. Material Methods: 124 patients (pharyngo)laryngectomy were analyzed for related data samples margins. The overall cohort was divided into with/withour tracheostomy. Results: 18 suffered from (10 stomal, 8 distant metastases). Advanced T-status, female gender, sub-/glottic manifestation resulted a higher rate prior...
Purpose: The pathophysiology of angioedema induced by angiotensin-converting enzyme inhibitors (ACEi) is not well understood. While activation bradykinin (BK) type 2 receptors (B2) has been established, the triggering events remain obscure. In this study we investigated effect NO as one product B2 stimulation. Methods: Brain (bEND3), human umbilical vein (HUVEC) and porcine aortic endothelial cells (PAEC) were incubated with NO-donors DEA/NO (10μM), DETA/NO (100μM) SNAP (1-100μM) for 3, 6 12...
Giriş: Dikkat Eksikliği/Hiperaktivite Bozukluğu (DEHB) günlük yaşamda önemli bozulmalara neden olmaktadır. DEHB'de alkol ve madde kullanım bozukluklarının (AMKB) sıklığı genel toplumdan daha yüksektir. Amaç: AMKB ile ilişkili sorunlar nedeniyle zorunlu tedavi için hastaneye yatırılan hastalarda çocukluk erişkinlik döneminde DEHB belirtilerinin yaygınlığını sorunları araştırmayı amaçladık. Gereç Yöntem: Örneklem 100 hastasından oluşmuştur. Sosyodemografik özellikleri, olası alkol-madde içeren...
Das Angioödem ist eine ödematöse Schwellung tieferer Hautschichten. Akute Angioödeme bedeuten vor allem dann einen klinischen Notfall, wenn die obere Atem-Schluck-Straße betroffen und Atmung der Patienten beeinträchtigt ist. Für rasche wirksame Therapie es notwendig, allergische von nicht allergischen Angioödemen zu unterscheiden. Von den 5 Unterformen allergischer sind 3 durch Bradykinin vermittelt: Blocker des Renin-Angiotensin-Aldosteron-Systems (RAAS) induzierte (RAE), das hereditäre...
Several forms of angioedema seem to be induced by elevated bradykinin (BK) concentrations. They are either caused increased BK production, as is the case in hereditary (HAE) involving lack a functional C1-esterase inhibitor, or reduced inactivation (e.g. during ACE-inhibitor treatment). BK-induced does not respond current standard treatment for histamine levels, corticosteroids and antihistamines. Until now acute attacks HAE have been treated with intravenously administered inhibitor...
Das durch die Angiotensin-Converting-Enzyme-Hemmer (ACEH) induzierte Angioödem des Kopf-Hals-Bereichs ist eine potentiell lebensbedrohliche Komplikation dieser zur Behandlung kardiovaskulärer Erkrankungen häufig eingesetzten Medikamentengruppe. Vor dem Hintergrund der noch ungeklärten Pathophysiologie ACEH-induzierten Angioödems untersuchten wir seine Korrelation mit funktionell relevanten I/D ACE-Polymorphismus. Hierbei handelt es sich um 287 Basenpaare lange Sequenz im Intron 16 ACE-Gens,...