A5023042888- Head and Neck Cancer Studies
- Obstructive Sleep Apnea Research
- Cancer Diagnosis and Treatment
- Neuroscience of respiration and sleep
- Ear and Head Tumors
- Salivary Gland Tumors Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Head and Neck Surgical Oncology
- Lung Cancer Treatments and Mutations
- Voice and Speech Disorders
- Dysphagia Assessment and Management
- Cancer-related gene regulation
- Heat shock proteins research
- Ear Surgery and Otitis Media
- Cancer-related Molecular Pathways
- Bone Tumor Diagnosis and Treatments
- Glycogen Storage Diseases and Myoclonus
- RNA modifications and cancer
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Artificial Intelligence in Healthcare and Education
- Oral and Maxillofacial Pathology
- Peptidase Inhibition and Analysis
- Molecular Biology Techniques and Applications
- Respiratory Support and Mechanisms
- Cancer Immunotherapy and Biomarkers
Technical University of Munich
2016-2025
RWTH Aachen University
2025
Klinik und Poliklinik für Hals-, Nasen-, Ohrenheilkunde
2023-2024
Klinikum rechts der Isar
2015-2024
München Klinik
2020-2024
Ludwig-Maximilians-Universität München
2011-2024
German Cancer Research Center
2024
Heidelberg University
2024
Deutschen Konsortium für Translationale Krebsforschung
2024
Klinik und Poliklinik für Hals-, Nasen-, Ohrenheilkunde
2021
Type 1 conventional dendritic cells (cDC1) can support T cell responses within tumors but whether this determines protective versus ineffective anti-cancer immunity is poorly understood. Here, we use imaging-based deep learning to identify intratumoral cDC1-CD8+ clustering as a unique feature of immunity. These clusters form selectively in stromal tumor regions and constitute niches which cDC1 activate TCF1+ stem-like CD8+ cells. We distinct population immunostimulatory CCR7neg that produce...
Visual diagnosis is one of the key features squamous cell carcinoma oral cavity (OSCC) and oropharynx (OPSCC), both subsets head neck (HNSCC) with a heterogeneous clinical appearance. Advancements in artificial intelligence led to Image recognition being introduced recently into large language models (LLMs) such as ChatGPT 4.0. This exploratory study, for first time, evaluated application image by diagnose leukoplakia based on images, images without any lesion control group. A total 45 were...
Objectives/Hypothesis Selective upper airway stimulation (sUAS) of the hypoglossal nerve is a useful therapy to treat patients with obstructive sleep apnea. Is it known that multiple obstructions can be solved by this technique, even at retropalatal region. The aim study was verify palatoglossus coupling soft palate during stimulation. Study Design Single‐center, prospective clinical trail. Methods Twenty who received an sUAS implant from April 2015 2016 were included. A drug‐induced sedated...
Background Head and neck squamous cell carcinoma (HNSCC) is a complex malignancy that requires multidisciplinary approach in clinical practice, especially tumor board discussions. In recent years, artificial intelligence has emerged as tool to assist healthcare professionals making informed decisions. This study investigates the application of ChatGPT 3.5 4.0, natural language processing models, decision-making. Methods We conducted pilot October 2023 on 20 consecutive head cancer patients...
Head and neck squamous cell carcinoma (HNSCC) is a complex malignancy that requires multidisciplinary tumor board approach for individual treatment planning. In recent years, artificial intelligence tools have emerged to assist healthcare professionals in making informed decisions. This study investigates the application of newly published LLM Claude 3 Opus compared currently most advanced ChatGPT 4.0 diagnosis therapy planning primary HNSCC. The results were conventional board; (2)...
<title>Abstract</title> <bold>(1) Objectives: </bold>Artificial intelligence (AI) has demonstrated potential in supporting decision making processes oncology by assisting the multidisciplinary tumor board (MDT). This study evaluates performance of two AI-based decision-support tools, most recently introduced ChatGPT o1 and established 4o, compared to MDT treatment recommendations head neck squamous cell carcinoma (HNSCC). Survival outcomes patterns were analyzed a large publicly accessible...
Abstract Tumor budding (TB) is a prognostic biomarker in HPV-negative and HPV-positive head neck squamous cell carcinoma (HNSCC). Analyzing TCGA CPTAC mutation, RNA, RPPA data performing proteomics IHC two independent in-house cohorts, we uncovered molecular correlates of TB an unprecedentedly comprehensive manner. NSD1 mutations were associated with lower HNSCC. Comparing nonbudding tumors, 66 miRNAs, including the miRNA-200 family, differentially expressed 3,052 (HPV-negative HNSCC) 360...
Recurrent and metastatic head neck squamous cell carcinoma (HNSCC) is characterized by a complex therapeutic management that needs to be discussed in multidisciplinary tumor boards (MDT). While artificial intelligence (AI) improved significantly assist healthcare professionals making informed treatment decisions for primary cases, an application the even more recurrent/metastatic setting has not been evaluated yet. This study also represents first evaluation of recently published LLM ChatGPT...
The unknown tissue of origin in head and neck cancer primary (hnCUP) leads to invasive diagnostic procedures unspecific potentially inefficient treatment options for patients. most common histologic subtype, squamous cell carcinoma, can stem from various tumor sites, including the oral cavity, oropharynx, larynx, skin, lungs, esophagus. DNA methylation profiles are highly tissue-specific have been successfully used classify origin. We therefore developed a support vector machine (SVM)...
Abstract Background We aimed to validate the prognostic significance of tumor budding (TB) in p16-positive oropharyngeal squamous cell carcinomas (OPSCC). Methods analyzed digitized H&E-stained slides from a multicenter cohort five large university centers consisting n = 275 cases OPSCC. evaluated TB along with other histological parameters (morphology, tumor-stroma-ratio, lymphovascular invasion (LVI), perineural invasion) and calculated survival outcomes using both univariate...
Background: Radiotherapy alone or in combination with radical hysterectomy remains a potentially curative treatment for cervical carcinoma. Late urological complications after radiotreatment are rare but often present difficult problems of management due to the progressive nature radiogenic tissue damage. We reviewed all cases urologic radiotherapy carcinoma treated at our institution over past 10 years. Patients and Methods: In retrospective analysis, out female patients hydronephrosis (n =...
Abstract Background Pre-operative treatment planning in head and neck squamous cell carcinoma (HNSCC) is mainly dictated by clinical staging, which has major shortcomings. Histologic grading irrelevant due to its lack of prognostic impact. Recently, a novel termed Cellular Dissociation Grade (CDG) based on Tumour Budding Cell Nest Size was shown be highly for resected HNSCC. We aimed probe the predictive impact CDG pre-operative biopsies Methods evaluated n = 160 pre-therapeutic from...
The aim of this study was to evaluate the efficiency cetuximab-based anti-EGFR treatment and Aurora kinase A / B knockdown as a function polymorphism in HNSCC cell lines.First, protein expression EGFR were studied tumour samples. survival proliferation homo- (Cal27) heterozygous (HN) lines evaluated using colony formation assay flow cytometric assay. Also, aneuploidy determined. signalling pathway visualised by western blotting.Immunohistochemistry revealed overexpression HNSCC. each caused...
Hypoglossal nerve stimulation (HNS) is a novel therapy in the treatment of obstructive sleep apnea. Previous studies have focused on effectiveness HNS, but there are no specifically investigating long-term changes intensities HNS. Increasing intensity requirements been reported past other peripheral therapies. The aim this study was to investigate development over observation period 4 years.All patients who were implanted with an HNS system since December 2013 and maintained bipolar...
The human gut microbiome is strongly influenced by the administration of drugs, namely antibiotics. We hypothesized that effectiveness immunotherapy with pembrolizumab in oral squamous cell carcinoma patients decreased antibiotics three months before and after immunotherapy.We retrieved data from diagnosed head neck (HNSCC) (International Classification Diseases [ICD]-10 codes C00-C14) receiving TriNetX network. Two cohorts were built: cohort I did not receive any within or up to...
The clinical impact of the expression NOTCH1 signaling components in squamous cell carcinoma pharynx and larynx has only been evaluated subgroups. aim this study was therefore to evaluate head neck cancer (HNSCC) patient tissue lines. We analyzed from 195 HNSCCs 30 normal patients for mRNA NOTCH1, NOTCH3, HES1, HEY1, JAG1 using quantitative real-time PCR. Association results orpathological factors examined with multivariate Cox regression. determined three Human Papilloma Virus...