A5012932520- Cancer-related gene regulation
- Renal and related cancers
- RNA modifications and cancer
- Cancer Research and Treatments
- CRISPR and Genetic Engineering
- Genetic factors in colorectal cancer
- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- Extracellular vesicles in disease
- Folate and B Vitamins Research
- GDF15 and Related Biomarkers
- Biochemical and Molecular Research
- Cancer-related molecular mechanisms research
- Head and Neck Cancer Studies
- Colorectal Cancer Surgical Treatments
- RNA Research and Splicing
- Colorectal Cancer Screening and Detection
- Digestive system and related health
- MicroRNA in disease regulation
- Adenosine and Purinergic Signaling
- Mast cells and histamine
- Lung Cancer Research Studies
- TGF-β signaling in diseases
- Microtubule and mitosis dynamics
- CAR-T cell therapy research
Instituto Português de Oncologia Francisco Gentil
2024
IPO Porto
2024
Technical University of Munich
2019-2023
Klinikum rechts der Isar
2017-2022
Universidade do Porto
2015-2021
German Cancer Research Center
2020
Deutschen Konsortium für Translationale Krebsforschung
2020
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2015-2017
Universidade Estadual da Paraíba
2014
Exosomes are lipid bilayer extracellular vesicles (EVs) of 50-150nm in size, which contain nucleic acids (mRNA, ncRNAs and DNA), proteins lipids. They secreted by all cells circulate body fluids. key mediators several processes cancer that mediate tumor progression metastasis. These nano-vesicles, when from cells, enriched non-coding RNAs (e.g. microRNAs) complexed with the RNA-Induced Silencing Complex (RISC), an efficient rapid silencing mRNAs at recipient cell, reprogramming their...
The 2019 World Health Organization (WHO) classification of colorectal carcinoma (CRC) profoundly reclassified CRC subtypes and introduces tumor budding as a second major grading criterion, while condensing conventional grade into 2-tiered system. So far it remains largely unexplored how these parameters interact with each other whether they truly have an independent impact on patient prognosis. We large single-center cohort 1004 CRCs spanning 2 decades for adjusted WHO (low vs. high),...
Background & AimsThroughout life, the intestinal epithelium undergoes constant self-renewal from stem cells. Together with genotoxic stressors and failing DNA repair, this causes susceptibility toward malignant transformation. X-box binding protein 1 (XBP1) is a stress sensor involved in unfolded response (UPR). We hypothesized that XBP1 acts as signaling hub to regulate epithelial damage responses.MethodsData The Cancer Genome Atlas were analyzed for association of colorectal cancer (CRC)...
Abstract Background Immunohistochemical loss of CDX2 has been proposed as a biomarker dismal survival in colorectal carcinoma (CRC), especially UICC Stage II/III. However, it remains unclear, how expression is related to central hematoxylin–eosin (HE)-based morphologic parameters defined by 2019 WHO classification and its prognostic relevance compared these parameters. Methods We evaluated 1003 CRCs explored CRC subtypes, tumour budding grade the overall cohort specific subgroups. Results...
In XIAP deficiency, ileitis is driven by TNFR1- and TNFR2-dependent targeting of TLR5-expressing Paneth dendritic cells.
Patients with end-stage renal disease are a challenge for oncologists. Despite the recognised benefit in overall survival of pembrolizumab patients advanced melanoma, data on its safety and efficacy dialysis scarce. We present clinical case an 87-year-old woman haemodialysis melanoma treated first line 200 mg every three weeks. She shows no significant adverse events good response to treatment. Although she underwent surgical treatment two oligoprogressions, patient maintained pembrolizumab,...
Abstract Growth and metastasis of colorectal cancer is closely connected to the biosynthetic capacity tumor cells, stem cells that reside at top intratumoral hierarchy are especially dependent on this feature. By performing disease modeling patient-derived organoids, we found elevated expression ribosome biogenesis factor NLE1 occurs upon SMAD4 loss in TGFβ1-exposed organoids. TGFβ signaling-mediated downregulation was prevented by ectopic c-MYC, which occupied an E-box–containing region...
Abstract Background Aberrations in DNA methylation are widespread colon cancer (CC). Understanding origin and progression of aberrations is essential to develop effective preventive therapeutic strategies. Here, we aimed dissect CC subtype-specific instability understand underlying mechanisms functions. Methods We have assessed genome-wide the healthy normal mucosa (HNM), precursor lesions CCs a first comprehensive study delineate epigenetic change along process carcinogenesis....
Abstract Background Pre-operative treatment planning in head and neck squamous cell carcinoma (HNSCC) is mainly dictated by clinical staging, which has major shortcomings. Histologic grading irrelevant due to its lack of prognostic impact. Recently, a novel termed Cellular Dissociation Grade (CDG) based on Tumour Budding Cell Nest Size was shown be highly for resected HNSCC. We aimed probe the predictive impact CDG pre-operative biopsies Methods evaluated n = 160 pre-therapeutic from...
Background: Special AT-rich sequence-binding protein 2 (SATB2) has emerged as an alternative immunohistochemical marker to CDX2 for colorectal differentiation. However, the distribution and prognostic relevance of SATB2 expression in carcinoma (CRC) have be further elucidated. Methods: was analysed 1039 CRCs correlated with clinicopathological morphological factors, well survival parameters within overall cohort subgroups. Results: loss a strong prognosticator univariate analyses (p <...
Preoperative (neoadjuvant) radiation therapy (RT) is an essential part of multimodal rectal cancer therapy. Recently, total neoadjuvant (TNT), which combines simultaneous radiochemotherapy with additional courses chemotherapy, has emerged as effective approach. TNT achieves a pathologic complete remission in approximately 30% resected patients, opening avenues for treatment strategies that avoid radical organ resection. Furthermore, recent studies have demonstrated anti-programmed cell death...
Abstract Background Prostate cancer (PrCa) is the most frequently diagnosed in men. Variants known moderate- to high-penetrance genes explain less than 5% of cases arising at early-onset (< 56 years) and/or with familial aggregation disease. Considering that BubR1 an essential component mitotic spindle assembly checkpoint, we hypothesized monoallelic BUB1B variants could be sufficient fuel chromosomal instability (CIN), potentially triggering (prostate) carcinogenesis. Methods To unveil...
Tumour budding (TB) has been associated with adverse clinicopathological factors and poor survival in a plethora of therapy-naïve carcinoma entities including gastric adenocarcinoma (GC). As conventional histopathological grading is usually omitted the post-neoadjuvant setting GC, our study aimed to investigate prognostic impact TB GCs resected after neoadjuvant therapy. We evaluated according criteria from International Budding Consensus Conference (ITBCC) 167 resections intestinal-type GC...
Mast cells (MCs) are crucial players in the relationship between tumor microenvironment (TME) and cancer have been shown to influence angiogenesis progression of human colorectal (CRC). However, role MCs TME is controversially discussed as either pro- or anti-tumorigenic. Genetically engineered mouse models (GEMMs) most frequently used vivo for CRC research. In murine intestine there at least three different MC subtypes: interepithelial mucosal mast (ieMMCs), lamina proprial (lpMMCs)...
Introduction. Neoplasm of the head and neck can be treated surgically, by radiation, chemotherapy, or using combination these methods. In contrast to surgical radiation treatment which mostly have a local effect, chemotherapy in addition also systemic effect. Both XRT oral region affect health. The aim this study was assess health status quality life patients with cancer after receiving therapy. Material Methods. Quantitative, analytical cross-sectional research methods along application...
<div>Abstract<p>Growth and metastasis of colorectal cancer is closely connected to the biosynthetic capacity tumor cells, stem cells that reside at top intratumoral hierarchy are especially dependent on this feature. By performing disease modeling patient-derived organoids, we found elevated expression ribosome biogenesis factor NLE1 occurs upon SMAD4 loss in TGFβ1-exposed organoids. TGFβ signaling-mediated downregulation was prevented by ectopic c-MYC, which occupied an...
<p>Supplementary Materials Oligonucleotides, qRT-PCR primer pairs, and Taqman probe assays used in this study.</p>