A5106456806- Prostate Cancer Treatment and Research
- Forensic and Genetic Research
- Insect and Pesticide Research
- DNA Repair Mechanisms
- Glycosylation and Glycoproteins Research
- Race, Genetics, and Society
- Genomics and Phylogenetic Studies
- Cancer, Hypoxia, and Metabolism
- PARP inhibition in cancer therapy
- Chemokine receptors and signaling
- Prostate Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Cancer, Stress, Anesthesia, and Immune Response
- Plant and animal studies
- BRCA gene mutations in cancer
- Forensic Anthropology and Bioarchaeology Studies
- Neuropeptides and Animal Physiology
- Proteoglycans and glycosaminoglycans research
- Insect and Arachnid Ecology and Behavior
- Probiotics and Fermented Foods
- Genetic Associations and Epidemiology
- Pacific and Southeast Asian Studies
- Advanced Proteomics Techniques and Applications
- Rabbits: Nutrition, Reproduction, Health
Instituto Português de Oncologia Francisco Gentil
2020-2025
IPO Porto
2015-2025
Research Network (United States)
2023
Universidade do Porto
2015-2017
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2017
University of Washington
2015
Washington Center
2015
University of Trás-os-Montes and Alto Douro
2010-2011
Institute for Biotechnology and Bioengineering
2010-2011
There are two very different interpretations of the prehistory Island Southeast Asia (ISEA), with genetic evidence invoked in support both. The "out-of-Taiwan" model proposes a major Late Holocene expansion Neolithic Austronesian speakers from Taiwan. An alternative, proposing that Glacial/postglacial sea-level rises triggered largely autochthonous dispersals, accounts for some otherwise enigmatic patterns, but fails to explain language dispersal. Combining mitochondrial DNA (mtDNA),...
Abstract There has been a long-standing debate concerning the extent to which spread of Neolithic ceramics and Malay-Polynesian languages in Island Southeast Asia (ISEA) were coupled an agriculturally driven demic dispersal out Taiwan 4000 years ago (4 ka). We previously addressed this question using founder analysis mitochondrial DNA (mtDNA) control-region sequences identify major lineage clusters most likely have dispersed from into ISEA, proposing that had relatively minor impact on...
India is a patchwork of tribal and non-tribal populations that speak many different languages from various language families. Indo-European, spoken across northern central India, also in Pakistan Bangladesh, has been frequently connected to the so-called "Indo-Aryan invasions" Central Asia ~3.5 ka establishment caste system, but extent immigration at this time remains extremely controversial. South on other hand, dominated by Dravidian languages. displays high level endogamy due its strict...
Rationale: Bladder cancer (BC) management demands the introduction of novel molecular targets for precision medicine.Cell surface glycoprotein CD44 has been widely studied as a potential biomarker BC aggressiveness and stem cells.However, significant alternative splicing multiple glycosylation generate myriad glycoproteoforms with potentially distinct functional roles.The lack tools precise characterization led to conflicting results, delaying clinical applications.Addressing these...
The identification of recurrent founder variants in cancer predisposing genes may have important implications for implementing cost-effective targeted genetic screening strategies. In this study, we evaluated the prevalence and relative risk
Prostate cancer (PrCa) is one of the three most frequent and deadliest cancers worldwide. The discovery PARP inhibitors for treatment tumors with deleterious variants in homologous recombination repair (HRR) genes has placed PrCa on roadmap precision medicine. However, overall contribution HRR to 10%-20% carcinomas arising men early-onset/familial not been fully clarified. We used targeted next-generation sequencing (T-NGS) covering eight (ATM, BRCA1, BRCA2, BRIP1, CHEK2, NBN, PALB2, RAD51C)...
A high-resolution mtDNA phylogenetic tree allowed us to look backward in time investigate purifying selection. Purifying selection was very strong the last 2,500 years, continuously eliminating pathogenic mutations back until end of Younger Dryas (∼11,000 years ago), when a large population expansion likely relaxed pressure. This preceded by phase stable another relaxation occurred out-of-Africa migration. Demography and are closely related: expansions led higher pathogenicity significantly...
P-glycoprotein (P-GP) is a transporter molecule expressed on the apical surface of capillary endothelial cells Blood–Brain Barrier (BBB), whose activity heavily influences drug distribution, including antidepressants. This encoded by ABCB1 gene, and genetic variations within gene have been proposed to affect efflux previously associated with depression. In this context, we aimed evaluate role C1236T, G2677TA C3435T polymorphisms in antidepressant treatment phenotypes from cohort patients...
Abstract Background Prostate cancer (PrCa) is the most frequently diagnosed in men. Variants known moderate- to high-penetrance genes explain less than 5% of cases arising at early-onset (< 56 years) and/or with familial aggregation disease. Considering that BubR1 an essential component mitotic spindle assembly checkpoint, we hypothesized monoallelic BUB1B variants could be sufficient fuel chromosomal instability (CIN), potentially triggering (prostate) carcinogenesis. Methods To unveil...
Genetic testing to detect somatic alterations is usually performed on formalin-fixed paraffin-embedded tumor samples. However, molecular profiling through ctDNA analysis may be particularly interesting with the emergence of targeted therapies for ovarian cancer (OC), mainly when not available and biopsy viable, also allowing representation multiple neoplastic subclones. Using a custom panel 27 genes, next-generation sequencing (NGS) was matched plasma samples from 96 OC patients, which were...
Abstract Bladder tumours with aggressive characteristics often present microenvironmental niches marked by low oxygen levels (hypoxia) and limited glucose supply due to inadequate vascularization. The molecular mechanisms facilitating cellular adaptation these stimuli remain largely elusive. Employing a multi-omics approach, we discovered that hypoxic glucose- deprived cancer cells enter quiescent state supported mitophagy, fatty acid β -oxidation, amino catabolism, concurrently enhancing...
Colorectal cancer (CRC) cells express sialylated Lewis antigens (sLe), crucial for metastasis via E-selectin binding. However, these glycoepitopes lack specificity, and E-selectin-targeted glycoproteins remain largely unknown. Here, we established a framework identifying metastasis-linked glycoproteoforms. More than 70% of CRC tumors exhibited overexpression sLeA/X, yet without discernible associations with or survival. The Cancer Genome Atlas (TCGA) analysis unveiled differing expression...
Abstract Prostate cancer (PrCa) is among the three top most frequent and deadlier cancers worldwide. The discovery of PARP inhibitors for treatment tumors having deleterious variants in homologous recombination repair (HRR) genes has placed PrCa roadmap precision medicine. Still, overall contribution HRR 10-20% carcinomas arising men with early-onset/familial not been fully clarified. We used Targeted Next Generation Sequencing (T-NGS) covering eight ( ATM , BRCA1 BRCA2 BRIP1 CHEK2 NBN PALB2...