A5088208879- Glycosylation and Glycoproteins Research
- Immunotherapy and Immune Responses
- Coronary Interventions and Diagnostics
- Chemokine receptors and signaling
- Cancer Genomics and Diagnostics
- Monoclonal and Polyclonal Antibodies Research
- Cancer, Stress, Anesthesia, and Immune Response
- Neuropeptides and Animal Physiology
- Sarcoma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Context-Aware Activity Recognition Systems
- Cancer-related molecular mechanisms research
- Salivary Gland Tumors Diagnosis and Treatment
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Sexual function and dysfunction studies
- Fish biology, ecology, and behavior
- HER2/EGFR in Cancer Research
- Urinary and Genital Oncology Studies
- Musculoskeletal synovial abnormalities and treatments
- Histiocytic Disorders and Treatments
- Health Education and Validation
- Cerebrovascular and Carotid Artery Diseases
- Smart Grid Energy Management
- Parvovirus B19 Infection Studies
Instituto Português de Oncologia Francisco Gentil
1991-2025
IPO Porto
2023-2025
Centro Hospitalar de Entre o Douro e Vouga E.P.E.
2024
Universidade Federal da Bahia
2024
Research Network (United States)
2023
Universidade Federal de Viçosa
2007
Hospital de São João
2007
Immature O-glycosylation of plasma membrane proteins, characterized by the presence glycosites with a single GalNAc residue (the Tn antigen) rather than more extended and complex glycans, is prominent feature many advanced solid tumors across different origins aetiologies. This form glycosylation has been strongly associated poor prognosis known to play crucial role in progression disease. Notably, it directly implicated crosstalk immune system, inducing tolerogenic phenotypes both innate...
Objetivo: Relatar a experiência dos acadêmicos de medicina na implantação do curso práticas pré-hospitalares em uma Universidade Medicina. Método: Trata-se um relato descritivo realizado por com aulas teóricas e sobre temas emergências pré-hospitalares. Resultado: O Emergências Pré-hospitalares (CEMEPH) teve 40 participantes, incluindo 39 estudantes socorrista SAMU. A avaliação demonstrou melhoria significativa no conhecimento maioria migrando níveis iniciais (graus 1 2) para os avançados 4...
Advanced-stage solid primary tumors and metastases often express mucin 16 (MUC16), carrying immature glycans such as the Tn antigen, resulting in specific glycoproteoforms not found healthy human tissues. This presents a valuable approach for designing targeted therapeutics, including cancer glycovaccines, which could potentially promote antigen recognition foster immune response to control disease spread prevent relapse. In this study, we describe an adjuvant-free poly(lactic-co-glycolic...
Colorectal cancer (CRC) screening relies primarily on stool analysis to identify occult blood. However, its sensitivity for detecting precancerous lesions is limited, requiring the development of new tools improve CRC screening. Carcinogenesis involves significant alterations in mucosal epithelium glycocalyx that decisively contribute disease progression. Building this knowledge, we examined patient series comprehending premalignant lesions, colorectal tumors, and healthy controls...
The aim of this study was to investigate the breast cancer (BC) molecular subtypes according its surrogate immunohistochemistry (IHC) markers. We conducted a preliminary study, correlate clinical pathological profiles and in Luanda, Angola.From January 2011 30 December 2014, 140 consecutive cases microscopically confirmed invasive carcinoma were classified regarding histology IHC (ER, PR, HER2, Ki-67). Surrogate ESMO recommendations.All patients female; median age 47 years (24-84 years)....
Muscle-invasive bladder cancer (MIBC) remains a pressing health concern due to conventional treatment failure and significant molecular heterogeneity, hampering the development of novel targeted therapeutics. In our quest for targetable markers, recent glycoproteomics bioinformatics data have pinpointed (glucose transporter 1) GLUT1 as potential biomarker its increased expression in tumours compared healthy tissues. This study explores this hypothesis more detail, with emphasis on...
Humeral shaft fractures are common, but proximal metadiaphyseal unusual and represent challenging injuries.Their treatment is still controversial debatable.Lateral minimally invasive osteosynthesis (MIPO) represents an alternative for those fractures, there a lack of studies describing this technique.We retrospectively reviewed six patients with humeral treated lateral MIPO.All the reached consolidation.We had one case postoperative radial neuropraxia that entirely resolved time, was no...
Abstract Bladder tumours with aggressive characteristics often present microenvironmental niches marked by low oxygen levels (hypoxia) and limited glucose supply due to inadequate vascularization. The molecular mechanisms facilitating cellular adaptation these stimuli remain largely elusive. Employing a multi-omics approach, we discovered that hypoxic glucose- deprived cancer cells enter quiescent state supported mitophagy, fatty acid β -oxidation, amino catabolism, concurrently enhancing...
Colorectal cancer (CRC) cells express sialylated Lewis antigens (sLe), crucial for metastasis via E-selectin binding. However, these glycoepitopes lack specificity, and E-selectin-targeted glycoproteins remain largely unknown. Here, we established a framework identifying metastasis-linked glycoproteoforms. More than 70% of CRC tumors exhibited overexpression sLeA/X, yet without discernible associations with or survival. The Cancer Genome Atlas (TCGA) analysis unveiled differing expression...
Introduction: Cystic bony defects of the humeral head are often encountered during rotator cuff arthroscopic repair.These may be idiopathic or secondary to suture anchor placement from previous repairs.Some cysts visible on preoperative magnetic resonance imaging (MRI), but most them discovered footprint preparation implant removal surgery.These osseous fragility zones, which reduce biological healing capacity and decrease repair fixation strength, lead significant treatment problems...