A5071183742- Glycosylation and Glycoproteins Research
- Cancer, Hypoxia, and Metabolism
- Bladder and Urothelial Cancer Treatments
- Immunotherapy and Immune Responses
- RNA modifications and cancer
- Advanced Proteomics Techniques and Applications
- Epigenetics and DNA Methylation
- Urinary and Genital Oncology Studies
- MicroRNA in disease regulation
- Cancer Research and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Salmonella and Campylobacter epidemiology
- Extracellular vesicles in disease
- Carbohydrate Chemistry and Synthesis
- Cassava research and cyanide
- Proteoglycans and glycosaminoglycans research
- Breast Implant and Reconstruction
- Metabolomics and Mass Spectrometry Studies
- Liver Disease Diagnosis and Treatment
- Periodontal Regeneration and Treatments
- Advanced Breast Cancer Therapies
- Circular RNAs in diseases
- Cancer, Lipids, and Metabolism
- Body Contouring and Surgery
- Immune responses and vaccinations
Instituto Português de Oncologia Francisco Gentil
2015-2025
IPO Porto
2015-2025
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2021-2025
Universidade do Porto
2011-2025
Institute of Biomedical Science
2021-2023
Research Network (United States)
2023
Therapeutics Clinical Research
2021
University of Aveiro
2019-2020
Rationale: Bladder cancer (BC) management demands the introduction of novel molecular targets for precision medicine.Cell surface glycoprotein CD44 has been widely studied as a potential biomarker BC aggressiveness and stem cells.However, significant alternative splicing multiple glycosylation generate myriad glycoproteoforms with potentially distinct functional roles.The lack tools precise characterization led to conflicting results, delaying clinical applications.Addressing these...
Abstract Extracellular vesicles (EVs) are lipid-membrane enclosed structures that associated with several diseases, including those of genitourinary tract. Urine contains EVs derived from urinary tract cells. Owing to its non-invasive collection, urine represents a promising source biomarkers for disorders, cancer. The most used method separation is differential ultracentrifugation (UC), but current protocols lead significant loss hampering efficiency. Moreover, UC labor-intensive, further...
Background: Gastric cancer (GC) is a major health burden worldwide, with half of patients developing metastases within 5 years after treatment, urging novel biomarkers for diagnosis and efficient therapeutic targeting. Sialyl-Lewis A (SLeA), terminal glycoepitope glycoproteins glycolipids, offers tremendous potential towards this objective. It rarely expressed in healthy tissues blood cells, while it present highly metastatic cell lines metastases. SLeA also involved E-selectin mediated...
Muscle invasive bladder cancer (MIBC) remains amongst the deadliest genitourinary malignancies due to treatment failure and extensive molecular heterogeneity, delaying effective targeted therapeutics. Hypoxia nutrient deprivation, oversialylation O-glycans shortening are salient features of aggressive tumours, creating cell surface glycoproteome fingerprints with theranostics potential.A glycomics guided glycoproteomics workflow was employed identify potentially targetable biomarkers using...
Advanced-stage solid primary tumors and metastases often express mucin 16 (MUC16), carrying immature glycans such as the Tn antigen, resulting in specific glycoproteoforms not found healthy human tissues. This presents a valuable approach for designing targeted therapeutics, including cancer glycovaccines, which could potentially promote antigen recognition foster immune response to control disease spread prevent relapse. In this study, we describe an adjuvant-free poly(lactic-co-glycolic...
Background: The etiology and ideal clinical treatment of capsular contracture (CC) remain unresolved. Bacteria, especially coagulase-negative staphylococci, have been previously shown to accelerate the onset CC. role fibrin in capsule formation has also controversial.
The three most common genitourinary malignancies (prostate/kidney/bladder cancers) constitute a substantial proportion of all cancer cases, mainly in the elderly population. Early detection is key to maximizing patients’ survival, but lack highly accurate biomarkers that might be used through non-/minimally invasive methods has impaired progress this domain. Herein, we sought develop minimally test detect and discriminate among those urological cancers based on miRNAs assessment ddPCR....
Background: The mechanism(s) responsible for breast capsular contracture (CC) remain unknown, but inflammatory pathways play a role. Various molecules have been attached to implant shells in the hope of modifying or preventing CC. intrinsic antibacterial and antifungal activities chitosan related oligochitosan lend themselves well study infectious hypothesis; chitosan’s ability bind growth factors, its hemostatic action, activate macrophages, cause cytokine stimulation, increase production...
Muscle-invasive bladder cancer (MIBC) remains a pressing health concern due to conventional treatment failure and significant molecular heterogeneity, hampering the development of novel targeted therapeutics. In our quest for targetable markers, recent glycoproteomics bioinformatics data have pinpointed (glucose transporter 1) GLUT1 as potential biomarker its increased expression in tumours compared healthy tissues. This study explores this hypothesis more detail, with emphasis on...
Abstract Bladder cancer constitutes one of the deadliest genitourinary diseases, especially when diagnosed at late stages. These tumours harbour microenvironmental niches characterized by low levels oxygen (hypoxia) and limited glucose supply due to poor vascularization. However, synergic contribution these features disease development is poorly understood. Here, we demonstrated that cells with distinct histopathological molecular backgrounds responded similarly such stimuli. Cancer arrested...
Glycosyltransferases and nucleotide sugars are combined in single-pot settings to synthesize a library of cancer-associated MUC16 O-glycopeptides multivalent protein glycoconjugates foreseeing future development cancer glycovaccines.
Abstract Bladder tumours with aggressive characteristics often present microenvironmental niches marked by low oxygen levels (hypoxia) and limited glucose supply due to inadequate vascularization. The molecular mechanisms facilitating cellular adaptation these stimuli remain largely elusive. Employing a multi-omics approach, we discovered that hypoxic glucose- deprived cancer cells enter quiescent state supported mitophagy, fatty acid β -oxidation, amino catabolism, concurrently enhancing...
The Journal of Cancer Metastasis and Treatment is an open access journal focused on cancer metastasis treatment, including the occurrence, development, progression, metastasis, treatment oncologic disease. It covers basic, translational clinical research related to cell biology, genomics, precision medicine, oncology internal radiotherapy radiology, obstetrics gynecology, pediatrics, surgery, hematology, neurooncology, etc.
RESUMO O sorriso gengival (SG) é uma condição clínica na qual ocorre exposição ao sorrir maior que 3 mm e considerada alteração estética frequente população. As causas de S.G incluem erupção passiva alterada dos dentes, extrusão dentoalveolar, excesso maxilar vertical, músculos do lábio superior curtos ou hiperativos, bem com a combinação fatores supracitados. Várias modalidades terapêuticas têm sido propostas para correção dessa condição. uso da toxina botulínica tipo A (TBX-A) considerado...
A relevância da estética na prática odontológica cresceu notavelmente, assumindo um papel proeminente devido à crescente influência das mídias sociais. No entanto, essa ênfase estética, por vezes, desviou a atenção de problemas essenciais Odontologia, como cárie dentária, que frequentemente é negligenciada em favor procedimentos estéticos, facetas resina composta para melhorar aparência dentária. Este estudo investigou as preferências e percepções estéticas saúde bucal pacientes. Para isso,...
To investigate the impact of variant histologies (VH) urothelial carcinoma (UC) on survival outcomes after radical cystectomy (RC).Data from 181 patients with UC treated RC between January 2013 and December 2019 at a single tertiary care referral center were retrospectively accessed. All specimens assigned by genitourinary dedicated pathologists. Overall (OS), disease-specific (DSS) recurrence-free (RFS) evaluated using Kaplan-Meier methodology Cox proportional hazards regression.Of...
Urothelial bladder carcinoma (UBC), the most frequent type (90%) of cancer and second common malignancy urogenital region, is a relatively well understood cancer, with numerous studies concerning pathogenetic pathways, natural history tumor biology being reported. Despite this, it continues to remain challenge in oncology field, mostly due its relapsing progressive nature, heterogeneity response cisplatin-containing regimens. Although formulae based on clinical staging histopathological...