A5077687568- Cancer, Hypoxia, and Metabolism
- ATP Synthase and ATPases Research
- Bladder and Urothelial Cancer Treatments
- Enzyme function and inhibition
- Metabolism, Diabetes, and Cancer
- Peripheral Artery Disease Management
- Ion Transport and Channel Regulation
- Epigenetics and DNA Methylation
- Urinary and Genital Oncology Studies
- Angiogenesis and VEGF in Cancer
- Mitochondrial Function and Pathology
- Renal cell carcinoma treatment
- Biochemical Acid Research Studies
- Drug Transport and Resistance Mechanisms
- Ion channel regulation and function
- Nitric Oxide and Endothelin Effects
- Stroke Rehabilitation and Recovery
- Sarcoma Diagnosis and Treatment
- Lymphatic System and Diseases
- Metabolomics and Mass Spectrometry Studies
- Chemical Reactions and Mechanisms
- Neuroscience and Neural Engineering
- Sulfur Compounds in Biology
- Fibroblast Growth Factor Research
- Diagnosis and Treatment of Venous Diseases
University of Minho
2011-2024
Instituto Superior de Saúde do Alto Ave
2009-2012
The relapsing and progressive nature of bladder tumors, the heterogeneity in response to cisplatin‐containing regimens, are major concerns care urothelial carcinoma (UBC) patients. metabolic adaptations that alter tumor microenvironment thus contribute chemoresistance have been poorly explored UBC setting. We found significant associations between immunoexpressions microenvironment‐related molecules CD147, monocarboxylate transporters (MCTs) 1 4, CD44 CAIX tissue sections from 114 presence...
Proliferating cancer cells are able to reprogram their energy metabolism, favouring glycolysis even in the presence of oxygen and fully functioning mitochondria. Research is needed validate glycolysis-related proteins as prognostic/predictive biomarkers urothelial bladder carcinoma (UBC), a malignancy tagged by high recurrence rates poor response chemotherapy. Here, we assessed GLUT1, HK2, PFKL, PKM2, phospho-PDH, LDHA immunoexpression 76 UBC samples, differentiating among urothelial,...
Monocarboxylate transporters (MCTs) are vital for intracellular pH homeostasis by extruding lactate from highly glycolytic cells. These molecules key players of the metabolic reprogramming cancer cells, and evidence indicates a potential contribution in urothelial bladder (UBC) aggressiveness chemoresistance. However, specific role MCTs compartmentalization within tumors, namely their preponderance on tumor stroma, remains to be elucidated. Thus, we evaluated immunoexpression different...
Aims: Bladder cancer is the second most common malignancy of urogenital region. The majority bladder deaths occur as a consequence metastatic disease. Blood vessel density (BVD), surrogate marker for angiogenesis, has been shown to be predictive progression and poor prognosis, well lymphatic (LVD). aim this study was evaluate, in human urothelial (UBC), clinical prognostic significance lymphangiogenesis lymphovascular invasion, assessed with use specific immunohistochemical markers. Methods...
Triple negative breast cancer (TNBC) is a highly heterogenous disease not sensitive to endocrine or HER2 therapy and standardized treatment regimens are still missing. Therefore, development of novel TNBC approaches utmost relevance. Herein, the potential MAPK/ERK downregulation by RNAi-based therapeutics in panel mesenchymal stem-like cell lines was uncovered. Our data revealed that suppression one central nodes this signaling pathway, MEK1, affects proliferation, migration, invasion cells,...
This study aimed to assess the distribution of VEGF-C and VEGFR-3 expression in gastrointestinal stromal tumours (GISTs), analyse value lymphatic vessel density (LVD) a tumour that is believed preferentially metastasize through blood conduits. A panel immunohistochemical antibodies was used evaluate 51 cases genetically characterised GISTs: VEGF-C, VEGFR-3, D2-40 (for LVD assessment) CD31 density--BDV--assessment). The results were correlated with clinical-pathological data. large majority...
Oral potentially malignant disorders (OPMD) are associated with an increased risk of oral squamous cell carcinoma (OSCC). OSCC has aggressive profile and is the most prevalent among different head neck malignancies. Most patients diagnosed advanced stage tumors have a poor prognosis. Cancer cells able to reprogram their metabolism, even in presence oxygen, enhancing conversion glucose lactate via glycolytic pathway, phenomenon mainly regulated by hypoxia-inducible factor (HIF) signaling....
Advanced urothelial bladder cancer (UBC) patients are tagged by a dismal prognosis and high mortality rates, mostly due to their poor response standard-of-care platinum-based therapy. Mediators of chemoresistance not fully elucidated. This work aimed study the metabolic profile advanced UBC, in context cisplatin resistance. Three isogenic pairs parental cell lines (T24, HT1376 KU1919) matching cisplatin-resistant (R) sublines were used. A set functional assays was used perform screening on...
The main goal of this study was to assess whether the presence peripheral arterial disease (PAD) correlates with increased inflammatory cell infiltration. An observational, single-centre, and prospective conducted from January 2018 July 2022. Clinical characteristics anthropometric measures were registered. Consecutive PAD patients surgical indications for a common femoral artery approach varicose veins an indication ligation saphenofemoral junction included. In both groups, samples...
Urothelial bladder carcinoma (UBC) is heterogeneous in its pathology and clinical behaviour. Evaluation of prognostic predictive biomarkers necessary, order to produce personalised treatment options. The present study used immunohistochemistry evaluate UBC sections containing tumour non-tumour areas from 76 patients, for the detection p-mTOR, CD31 D2-40 (blood lymphatic vessels identification, respectively). Of sections, 36 20% were scored positive p-mTOR expression, respectively....
Introduction: Esophageal cancer (EC) seems to display increased glycolytic activity, but clinical studies on the expression/prognostic significance of glycometabolism-related proteins, as well functional assays, are missing. Methods: Expression 10 biomarkers was evaluated by immunohistochemistry in tissue sections from 95 patients. Two esophageal squamous cell carcinoma (ESCC) lines were used assess effect monocarboxylate transporter (MCT) downregulation viability and extracellular...
The Journal of Cancer Metastasis and Treatment is an open access journal focused on cancer metastasis treatment, including the occurrence, development, progression, metastasis, treatment oncologic disease. It covers basic, translational clinical research related to cell biology, genomics, precision medicine, oncology internal radiotherapy radiology, obstetrics gynecology, pediatrics, surgery, hematology, neurooncology, etc.