A5023736410- Synthesis of Organic Compounds
- Multicomponent Synthesis of Heterocycles
- Synthesis and biological activity
- Bioactive Compounds and Antitumor Agents
- Synthesis and Reactivity of Heterocycles
- Synthesis and pharmacology of benzodiazepine derivatives
- Bipolar Disorder and Treatment
- Synthesis of heterocyclic compounds
- Synthesis and Biological Evaluation
- Synthesis and Reactions of Organic Compounds
- Click Chemistry and Applications
- Genetics and Neurodevelopmental Disorders
- Cancer, Hypoxia, and Metabolism
- Cyclopropane Reaction Mechanisms
- Nanoplatforms for cancer theranostics
- Plant biochemistry and biosynthesis
- Synthesis and Characterization of Heterocyclic Compounds
- Traditional and Medicinal Uses of Annonaceae
- Adenosine and Purinergic Signaling
- Cannabis and Cannabinoid Research
- Genetic Syndromes and Imprinting
- Nanoparticle-Based Drug Delivery
- Essential Oils and Antimicrobial Activity
- Cancer Mechanisms and Therapy
- Chemical Synthesis and Reactions
University of Minho
2013-2024
Administração Regional de Saúde de Lisboa e Vale do Tejo
2024
Oxford Health NHS Foundation Trust
2024
University of Lisbon
2023
The Francis Crick Institute
2018
University College London
2017
CRUK Lung Cancer Centre of Excellence
2017
London Cancer
2017
University of Cagliari
2011-2015
Universidade Federal do Rio Grande do Norte
2006-2011
Immune evasion is a hallmark of cancer. Losing the ability to present neoantigens through human leukocyte antigen (HLA) loss may facilitate immune evasion. However, polymorphic nature locus has precluded accurate HLA copy-number analysis. Here, we heterozygosity in (LOHHLA), computational tool determine allele-specific copy number from sequencing data. Using LOHHLA, find that LOH occurs 40% non-small-cell lung cancers (NSCLCs) and associated with high subclonal neoantigen burden,...
The evolutionary features of clear-cell renal cell carcinoma (ccRCC) have not been systematically studied to date. We analyzed 1,206 primary tumor regions from 101 patients recruited into the multi-center prospective study, TRACERx Renal. observe up 30 driver events per and show that subclonal diversification is associated with known prognostic parameters. By resolving patterns event ordering, co-occurrence, mutual exclusivity at clone level, we deterministic nature clonal evolution. ccRCC...
CD25 is expressed at high levels on regulatory T (Treg) cells and was initially proposed as a target for cancer immunotherapy. However, anti-CD25 antibodies have displayed limited activity against established tumors. We demonstrated that expression largely restricted to tumor-infiltrating Treg in mice humans. While existing were observed deplete the periphery, upregulation of inhibitory Fc gamma receptor (FcγR) IIb tumor site prevented intra-tumoral cell depletion, which may underlie lack...
Proliferating cancer cells are able to reprogram their energy metabolism, favouring glycolysis even in the presence of oxygen and fully functioning mitochondria. Research is needed validate glycolysis-related proteins as prognostic/predictive biomarkers urothelial bladder carcinoma (UBC), a malignancy tagged by high recurrence rates poor response chemotherapy. Here, we assessed GLUT1, HK2, PFKL, PKM2, phospho-PDH, LDHA immunoexpression 76 UBC samples, differentiating among urothelial,...
Bipolar disorder (BD) is a lifelong psychiatric illness characterized by manic and depressive episodes affecting 1-5% of the general population. Among mood-stabilizing treatments, lithium represents mainstay in therapeutic management BD. However, besides relatively high rate excellent responders, significant fraction patients present patterns partial or nonresponse to lithium. This variability might be influenced genetic factors, even though findings have so far been inconclusive. Here, we...
Bipolar disorder (BD) is a debilitating psychiatric disease characterized by alternating episodes of mania and depression. Among mood stabilizers, lithium the mainstay for treatment BD, with approximately one-third patients showing remission from episode recurrence. While there evidence suggesting genetic load response in its molecular underpinnings are still not completely understood. To identify genes potentially involved (or correlated with) response, we carried out genome-wide expression...
The reaction of salicylic aldehydes with malononitrile was reinvestigated, and the pathway followed by 1H NMR spectroscopy. A delicate control experimental conditions allowed synthesis 2-imino-2H-chromene-3-carbonitriles 1, (2-amino-3-cyano-4H-chromen-4-yl)malononitriles 2, 4-amino-5-imino-2,7-dimethoxy-5H-chromeno[3,4-c]pyridine-1-carbonitrile 12, (4,5-diamino-1-cyano-1,10b-dihydro-2H-chromeno[3,4-c]pyridin-2-ylidene)malononitrile 13. Two novel 2-iminochromene dimers, structures 8 9, were...
Triple-negative breast cancer (TNBC) represents 15-25 % of the new cases diagnosed worldwide every year. TNBC is among most aggressive and worst prognosis cancer, mainly because targeted therapies are not available. Herein, we developed a magnetic theranostic hybrid nanovehicle for treatment through pH-triggered tumour associated macrophages (TAMs) targeting. The lipid core was composed Carnaúba wax matrix that simultaneously incorporated iron oxide nanoparticles doxorubicin (DOX) -...
"O Vírus da Leucemia Felina é um vírus disseminado mundialmente, onde se trata de Retrovírus. A FeLV pode evoluir para quatro tipos infecções, sendo elas a infecção progressiva, regressiva, abortiva e atípica ou focal, sua evolução vai depender do sistema imunológico felino subgrupo que esteja acometendo esse paciente. Seus sinais clínicos são inespecíficos o diagnóstico ser feito através ELISA, Imunocromatofragia, Imunofluorescência Indireta PCR, juntamente hemograma completo associado ao...
A series of new 2-imino-2H-chromene-3-carboxamides 5 were synthesized in excellent yield and high atom economy by the Knoevenagel condensation salicylaldehyde derivatives 4 N-substituted cyanoacetamides 3 using aqueous sodium carbonate or hydrogen solution, at room temperature. Treatment compounds with HCl led to formation corresponding 2-oxochromenes 6.
Triple negative breast cancer (TNBC) is a highly heterogenous disease not sensitive to endocrine or HER2 therapy and standardized treatment regimens are still missing. Therefore, development of novel TNBC approaches utmost relevance. Herein, the potential MAPK/ERK downregulation by RNAi-based therapeutics in panel mesenchymal stem-like cell lines was uncovered. Our data revealed that suppression one central nodes this signaling pathway, MEK1, affects proliferation, migration, invasion cells,...