Selvaraju Veeriah

ORCID: 0000-0002-1217-0387
Publications
Citations
Views
---
Saved
---
About
Contact & Profiles
Research Areas
  • Immunotherapy and Immune Responses
  • Cancer Immunotherapy and Biomarkers
  • Cancer Genomics and Diagnostics
  • Immune cells in cancer
  • Lung Cancer Treatments and Mutations
  • PI3K/AKT/mTOR signaling in cancer
  • RNA modifications and cancer
  • Monoclonal and Polyclonal Antibodies Research
  • Immune responses and vaccinations
  • Ferroptosis and cancer prognosis
  • Single-cell and spatial transcriptomics
  • Mechanisms of cancer metastasis
  • Lung Cancer Diagnosis and Treatment
  • Radiomics and Machine Learning in Medical Imaging
  • vaccines and immunoinformatics approaches
  • Cancer-related molecular mechanisms research
  • Cancer, Hypoxia, and Metabolism
  • Cancer Cells and Metastasis
  • Molecular Biology Techniques and Applications
  • Immune Cell Function and Interaction
  • AI in cancer detection
  • CAR-T cell therapy research
  • Lymphoma Diagnosis and Treatment
  • T-cell and B-cell Immunology
  • Genomics, phytochemicals, and oxidative stress

London Cancer
2014-2025

University College London
2014-2025

Cancer Research UK
2012-2025

CRUK Lung Cancer Centre of Excellence
2017-2025

The Francis Crick Institute
2017-2024

University College London Hospitals NHS Foundation Trust
2020

National Hospital for Neurology and Neurosurgery
2020

Memorial Sloan Kettering Cancer Center
2009-2014

Friedrich Schiller University Jena
2005-2009

University of Würzburg
2007

Among patients with non-small-cell lung cancer (NSCLC), data on intratumor heterogeneity and genome evolution have been limited to small retrospective cohorts. We wanted prospectively investigate in relation clinical outcome determine the clonal nature of driver events evolutionary processes early-stage NSCLC.

10.1056/nejmoa1616288 article EN New England Journal of Medicine 2017-04-26
Christopher Abbosh Nicolai J. Birkbak Gareth A. Wilson Mariam Jamal‐Hanjani T Constantin and 95 more Raheleh Salari John Le Quesne David A. Moore Selvaraju Veeriah Rachel Rosenthal Teresa Marafioti Eser Kırkızlar Anne Thomas Nicholas McGranahan Sophia Ward Luke Martinson Joan Riley Francesco Fraioli Maise Al Bakir Eva Grönroos Francisco Zambrana Raymondo Endozo Wenya Linda Bi Fiona M. Fennessy Nicole Sponer Diana Johnson Joanne Laycock Seema Shafi Justyna Czyzewska-Khan Andrew Rowan Tim Chambers Nik Matthews Samra Turajlic Crispin T. Hiley SM Lee Martin Förster Tanya Ahmad Mary Falzon Elaine Borg David Lawrence Sophia Ward Shyam Kolvekar Nikolaos Panagiotopoulos Sam M. Janes Ricky M. Thakrar Asia Ahmed Fiona Blackhall Yvonne Summers Dina Hafez Ashwini Naik Apratim Ganguly Stephanie Kareht Rajesh Shah Leena Dennis Joseph Anne Marie Quinn Philip Crosbie Babu Naidu Gary Middleton Gerald Langman Simon Trotter M. Nicolson Hardy Remmen Keith M. Kerr Mahendran Chetty Lesley Gomersall Dean A. Fennell Apostolos Nakas Sridhar Rathinam Girija Anand Sajid Khan Peter Russell Veni Ezhil Babikir Ismail Melanie Irvin-Sellers Vineet Prakash J.F. Lester Malgorzata Kornaszewska Richard Attanoos Haydn Adams Helen Davies Dahmane Oukrif Ayse U. Akarca John A. Hartley Helen L. Lowe Sara Lock Natasha Iles Harriet Bell Yenting Ngai Greg Elgar Zoltán Szállási Roland F. Schwarz Javier Herrero Grant D. Stewart Sergio A. Quezada Karl S. Peggs Peter Van Loo Caroline Dive C Jimmy Lin Matthew Rabinowitz Hugo J.W.L. Aerts

10.1038/nature22364 article EN Nature 2017-04-25
Nicholas McGranahan Rachel Rosenthal Crispin T. Hiley Andrew J. Rowan Thomas B.K. Watkins and 95 more Gareth A. Wilson Nicolai J. Birkbak Selvaraju Veeriah Peter Van Loo Javier Herrero Charles Swanton Charles Swanton Mariam Jamal‐Hanjani Selvaraju Veeriah Seema Shafi Justyna Czyzewska-Khan Diana Johnson Joanne Laycock Leticia Bosshard‐Carter Rachel Rosenthal Pat Gorman Robert E. Hynds Gareth A. Wilson Nicolai J. Birkbak Thomas B.K. Watkins Nicholas McGranahan Stuart Horswell Richard Mitter Mickael Escudero Aengus Stewart Peter Van Loo Andrew Rowan Hang Xu Samra Turajlic Crispin T. Hiley Christopher Abbosh Jacki Goldman Richard Stone Tamara Denner Nik Matthews Greg Elgar Sophia Ward Marta Costa Sharmin Begum Ben Phillimore Tim Chambers Emma Nye Sofia Graca Maise Al Bakir Kroopa Joshi Andrew J.S. Furness Assma Ben Aïssa Yien Ning Sophia Wong Andy Georgiou Sergio A. Quezada John A. Hartley Helen L. Lowe Javier Herrero David Lawrence Sophia Ward Nikolaos Panagiotopoulos Shyam Kolvekar Mary Falzon Elaine Borg Teresa Marafioti Celia Simeon Gemma Hector Amy Smith Marie Aranda Marco Novelli Dahmane Oukrif Sam M. Janes Ricky M. Thakrar Martin Förster Tanya Ahmad SM Lee Dionysis Papadatos-Pastos Dawn Carnell R. Mendes Jeremy George Neal Navani Asia Ahmed Magali N. Taylor Junaid Choudhary Yvonne Summers Raffaele Califano P. W. J. Taylor Rajesh Shah Piotr Krysiak Kendadai Rammohan Eustace Fontaine Richard Booton Matthew Evison Philip Crosbie Stuart Moss Faiza Idries Leena Dennis Joseph Paul N. Bishop Anshuman Chaturved Anne Marie Quinn

Immune evasion is a hallmark of cancer. Losing the ability to present neoantigens through human leukocyte antigen (HLA) loss may facilitate immune evasion. However, polymorphic nature locus has precluded accurate HLA copy-number analysis. Here, we heterozygosity in (LOHHLA), computational tool determine allele-specific copy number from sequencing data. Using LOHHLA, find that LOH occurs 40% non-small-cell lung cancers (NSCLCs) and associated with high subclonal neoantigen burden,...

10.1016/j.cell.2017.10.001 article EN cc-by Cell 2017-10-26
William Hill Emilia L. Lim Clare E. Weeden Claudia Lee Marcellus Augustine and 95 more Kezhong Chen Feng‐Che Kuan Fabio Marongiu Edward J. Evans David A. Moore Felipe Silva Rodrigues Oriol Pich Björn Bakker Hongui Cha Renelle Myers Febe van Maldegem Jesse Boumelha Selvaraju Veeriah Andrew Rowan Cristina Naceur‐Lombardelli Takahiro Karasaki Monica Sivakumar Swapnanil De Deborah R. Caswell A. Nagano James R. Black Carlos Martínez‐Ruiz Min Hyung Ryu Ryan D. Huff Shijia Li Marie-Julie Favé Alastair Magness Alejandro Suárez‐Bonnet Simon L. Priestnall Margreet Lüchtenborg K Lavelle Joanna Pethick Steven J. Hardy Fiona E. McRonald Meng‐Hung Lin Clara I. Troccoli Moumita Ghosh York E. Miller Daniel T. Merrick Robert L. Keith Maise Al Bakir Chris Bailey Mark S. Hill Lao H. Saal Yilun Chen Anthony M. George Christopher Abbosh Nnennaya Kanu Se‐Hoon Lee Nicholas McGranahan Christine D. Berg Peter Sasieni Richard S. Houlston Clare Turnbull Stephen Lam Philip Awadalla Eva Grönroos Julian Downward Tyler Jacks Christopher Carlsten Ilaria Malanchi Allan Hackshaw Kevin Litchfield J.F. Lester Amrita Bajaj Apostolos Nakas Azmina Sodha-Ramdeen Keng Ang Mohamad Tufail Mohammed Fiyaz Chowdhry Molly Scotland Rebecca Boyles Sridhar Rathinam Claire Wilson Domenic Marrone Sean Dulloo Dean A. Fennell Gurdeep Matharu Jacqui Shaw Joan Riley Lindsay Primrose Ekaterini Boleti Heather Cheyne Mohammed S. Khalil Shirley Richardson Tracey Cruickshank Gillian Price Keith M. Kerr Sarah Benafif Kayleigh Gilbert Babu Naidu Akshay J. Patel Aya Osman Christer Lacson Gerald Langman

10.1038/s41586-023-05874-3 article EN Nature 2023-04-05
Frederick Arce Vargas Andrew J.S. Furness Isabelle Solomon Kroopa Joshi Leila Mekkaoui and 95 more Marta H. Lesko Enrique Miranda Rony Dahan Andrew Georgiou Anna Śledzińska Assma Ben Aïssa Dafne Franz Mariana Werner Sunderland Yien Ning Sophia Wong Jake Y. Henry Tim O’Brien David Nicol Ben Challacombe Stephen A. Beers Samra Turajlic Martin Gore James Larkin Charles Swanton Kerry Chester Martin Pulé Jeffrey V. Ravetch Teresa Marafioti Karl S. Peggs Sergio A. Quezada Lavinia Spain Andrew Wotherspoon Nick Francis Myles Smith D. Strauß Andrew J. Hayes Aspasia Soultati Mark Stares Lavinia Spain Joanna Lynch Nicos Fotiadis Archana Fernando Steve Hazell Ashish Chandra Lisa Pickering Sarah Rudman Simon Chowdhury Charles Swanton Mariam Jamal‐Hanjani Selvaraju Veeriah Seema Shafi Justyna Czyzewska-Khan Diana Johnson Joanne Laycock Leticia Bosshard‐Carter Gerald Goh Rachel Rosenthal Pat Gorman Nirupa Murugaesu Robert E. Hynds Gareth A. Wilson Nicolai J. Birkbak Thomas B.K. Watkins Nicholas McGranahan Stuart Horswell Richard Mitter Mickael Escudero Aengus Stewart Peter Van Loo Andrew Rowan Hang Xu Samra Turajlic Crispin T. Hiley Christopher Abbosh Jacki Goldman Richard Stone Tamara Denner Nik Matthews Greg Elgar Sophia Ward Jennifer Biggs Marta Costa Sharmin Begum Ben Phillimore Tim Chambers Emma Nye Sofia Graca Maise Al Bakir John A. Hartley Helen L. Lowe Javier Herrero David Lawrence Sophia Ward Nikolaos Panagiotopoulos Shyam Kolvekar Mary Falzon Elaine Borg Celia Simeon Gemma Hector Amy Smith Marie Aranda

CD25 is expressed at high levels on regulatory T (Treg) cells and was initially proposed as a target for cancer immunotherapy. However, anti-CD25 antibodies have displayed limited activity against established tumors. We demonstrated that expression largely restricted to tumor-infiltrating Treg in mice humans. While existing were observed deplete the periphery, upregulation of inhibitory Fc gamma receptor (FcγR) IIb tumor site prevented intra-tumoral cell depletion, which may underlie lack...

10.1016/j.immuni.2017.03.013 article EN cc-by Immunity 2017-04-01

Tyrosine phosphorylation plays a critical role in regulating cellular function and is central feature signaling cascades involved oncogenesis. The regulation of tyrosine coordinately controlled by kinases phosphatases (PTPs). Whereas activation has been shown to play vital roles tumor development, the PTPs much less well defined. Here, we show that receptor protein phosphatase delta (PTPRD) frequently inactivated glioblastoma multiforme (GBM), deadly primary neoplasm brain. PTPRD target...

10.1073/pnas.0900571106 article EN Proceedings of the National Academy of Sciences 2009-05-29
Christopher Abbosh Alexander M. Frankell Thomas Harrison Judit Kisistók Aaron T. Garnett and 95 more Laura Johnson Selvaraju Veeriah Mike Moreau Adrian Chesh Tafadzwa L. Chaunzwa Jakob Weiss Morgan R. Schroeder Sophia Ward Kristiana Grigoriadis Aamir Shahpurwalla Kevin Litchfield Clare Puttick Dhruva Biswas Takahiro Karasaki James R. Black Carlos Martínez‐Ruiz Maise Al Bakir Oriol Pich Thomas B.K. Watkins Emilia L. Lim Ariana Huebner David A. Moore Nadia Godin-Heymann Anne L’Hernault Hannah Bye Aaron Odell Paula Roberts Fábio Gomes Akshay J. Patel Elizabeth Manzano Crispin T. Hiley Nicolas Carey Joan Riley Daniel E. Cook Darren Hodgson Daniel Stetson J. Carl Barrett Roderik M. Kortlever Gérard I. Evan Allan Hackshaw Robert Daber Jacqui Shaw Hugo J.W.L. Aerts Abel Licon Josh Stahl Mariam Jamal‐Hanjani J.F. Lester Amrita Bajaj Apostolos Nakas Azmina Sodha-Ramdeen Keng Ang Mohamad Tufail Mohammed Fiyaz Chowdhry Molly Scotland Rebecca Boyles Sridhar Rathinam Claire Wilson Domenic Marrone Sean Dulloo Dean A. Fennell Gurdeep Matharu Lindsay Primrose Ekaterini Boleti Heather Cheyne Mohammed S. Khalil Shirley Richardson Tracey Cruickshank Gillian Price Keith M. Kerr Sarah Benafif Kayleigh Gilbert Babu Naidu Aya Osman Christer Lacson Gerald Langman Helen Shackleford Madava Djearaman Salma Kadiri Gary Middleton Angela Leek Jack Davies Hodgkinson Nicola Totten Ángeles Montero Elaine Smith Eustace Fontaine Felice Granato Helen Doran Juliette Novasio Kendadai Rammohan Leena Dennis Joseph Paul N. Bishop Rajesh Shah Stuart Moss Vijay Joshi Philip Crosbie

10.1038/s41586-023-05776-4 article EN Nature 2023-04-13
Lewis Au Emine Hatipoglu Marc Robert de Massy Kevin Litchfield Gordon Beattie and 95 more Andrew Rowan Désirée Schnidrig R. Houston Thompson Fiona Byrne Stuart Horswell Nicos Fotiadis Steve Hazell David Nicol Scott T.C. Shepherd Annika Fendler Robert M. Mason Lyra Del Rosario Kim Edmonds Karla Lingard Sarah Sarker Mary Mangwende Eleanor Carlyle Jan Attig Kroopa Joshi Imran Uddin Pablo D. Becker Mariana Werner Sunderland Ayse U. Akarca Ignazio Puccio William Yang Tom Lund Kim Dhillon Marcos Duran Vasquez Ehsan Ghorani Hang Xu Charlotte Spencer José I. López Anna Green Ula Mahadeva Elaine Borg Miriam Mitchison David A. Moore Ian Proctor Mary Falzon Lisa Pickering Andrew J.S. Furness James L. Reading Roberto Salgado Teresa Marafioti Mariam Jamal‐Hanjani George Kassiotis Benny Chain James Larkin Charles Swanton Sergio A. Quezada Samra Turajlic Chris Abbosh Kai‐Keen Shiu John Bridgewater Daniel Hochhauser Martin Förster SM Lee Tanya Ahmad Dionysis Papadatos-Pastos Sam M. Janes Peter Van Loo Katey S.S. Enfield Nicholas McGranahan Ariana Huebner Stephan Beck Peter J. Parker Henning Walczak Tariq Enver Robert E. Hynds Ron Sinclair Chi-wah Lok Zoe Rhodes David A. Moore Reena Khiroya Giorgia Trevisan Peter Ellery Mark Linch Sebastian Brandner Crispin T. Hiley Selvaraju Veeriah Maryam Razaq Heather Shaw G. Attard Mita Afroza Akther Cristina Naceur‐Lombardelli Lizi Manzano Maise Al-Bakir Simranpreet Summan Nnenna Kanu Sophia Ward Uzma Asghar Emilia L. Lim Faye Gishen Adrian Tookman Paddy Stone

ADAPTeR is a prospective, phase II study of nivolumab (anti-PD-1) in 15 treatment-naive patients (115 multiregion tumor samples) with metastatic clear cell renal carcinoma (ccRCC) aiming to understand the mechanism underpinning therapeutic response. Genomic analyses show no correlation between molecular features and response, whereas ccRCC-specific human endogenous retrovirus expression indirectly correlates clinical T receptor (TCR) analysis reveals significantly higher number expanded TCR...

10.1016/j.ccell.2021.10.001 article EN cc-by Cancer Cell 2021-10-28
Alexander M. Frankell Michelle Dietzen Maise Al Bakir Emilia L. Lim Takahiro Karasaki and 95 more Sophia Ward Selvaraju Veeriah Emma Colliver Ariana Huebner Abigail Bunkum Mark S. Hill Kristiana Grigoriadis David A. Moore James R. Black Wing Kin Liu Kerstin Thol Oriol Pich Thomas B.K. Watkins Cristina Naceur‐Lombardelli Daniel E. Cook Roberto Salgado Gareth A. Wilson Chris Bailey Mihaela Angelova Robert B. Bentham Carlos Martínez‐Ruiz Christopher Abbosh Andrew G. Nicholson John Le Quesne Dhruva Biswas Rachel Rosenthal Clare Puttick Sonya Hessey Claudia Lee Paulina Prymas Antonia Toncheva Jon Smith Xing Wei Jérôme Nicod Gillian Price Keith M. Kerr Babu Naidu Gary Middleton Kevin G. Blyth Dean A. Fennell Martin Förster SM Lee Mary Falzon Madeleine Hewish Michael Shackcloth Eric Lim Sarah Benafif Peter Russell Ekaterini Boleti Matthew Krebs J.F. Lester Dionysis Papadatos-Pastos Tanya Ahmad Ricky M. Thakrar David Lawrence Neal Navani Sam M. Janes Caroline Dive Fiona Blackhall Yvonne Summers Judith Cave Teresa Marafioti Javier Herrero Sergio A. Quezada Karl S. Peggs Roland F. Schwarz Peter Van Loo Daniël M. Miedema Nicolai J. Birkbak Crispin T. Hiley Allan Hackshaw Simone Zaccaria John Le Quesne Peter Van Loo Amrita Bajaj Apostolos Nakas Azmina Sodha-Ramdeen Keng Ang Mohamad Tufail Mohammed Fiyaz Chowdhry Molly Scotland Rebecca Boyles Sridhar Rathinam Claire Wilson Domenic Marrone Sean Dulloo Gurdeep Matharu Jacqui Shaw Joan Riley Lindsay Primrose Heather Cheyne Mohammed S. Khalil Shirley Richardson Tracey Cruickshank Kayleigh Gilbert

Lung cancer is the leading cause of cancer-associated mortality worldwide

10.1038/s41586-023-05783-5 article EN cc-by Nature 2023-04-12
Kevin W. Ng Jesse Boumelha Katey S.S. Enfield Jorge Almagro Hongui Cha and 95 more Oriol Pich Takahiro Karasaki David A. Moore Roberto Salgado Monica Sivakumar George R. Young Míriam Molina‐Arcas Sophie de Carné Trécesson Panayiotis Anastasiou Annika Fendler Lewis Au Scott T.C. Shepherd Carlos Martínez‐Ruiz Clare Puttick James R. Black Thomas B.K. Watkins Hye Min Kim Seohee Shim Nikhil Faulkner Jan Attig Selvaraju Veeriah Neil Magno Sophia Ward Alexander M. Frankell Maise Al Bakir Emilia L. Lim Mark S. Hill Gareth A. Wilson Daniel E. Cook Nicolai J. Birkbak Axel Behrens Nadia Yousaf Sanjay Popat Allan Hackshaw Andrew Rowan Ariana Huebner Brittany Campbell Chris Bailey Claudia Lee Dhruva Biswas Emma Colliver Foteini Athanasopoulou Hao-Ran Zhai Jayant K. Rane Kristiana Grigoriadis Michelle Dietzen Michelle Leung Mihaela Angelova Olivia Lucas Othman Al‐Sawaf Rachel Rosenthal Jérôme Nicod Abigail Bunkum Antonia Toncheva Christopher Abbosh Corentin Richard Cristina Naceur‐Lombardelli Francisco Gimeno-Valiente Jie Min Lam Kerstin Thol Krupa Thakkar Mariana Werner Sunderland Martin Förster Nnennaya Kanu Paulina Prymas Robert B. Bentham Sadegh Saghafinia Sergio A. Quezada Sharon Vanloo Simone Zaccaria SM Lee Sonya Hessey Wing Kin Liu Dionysis Papadatos-Pastos James M. Wilson Sarah Benafif Tanya Ahmad Elaine Borg Mary Falzon Reena Khiroya Teresa Marafioti Abigail Sharp Camilla Pilotti Harjot Kaur Dhanda Kitty S. Chan Nicole Gower Rachel Leslie Sean Smith Andrew G. Nicholson Eric Lim Javier Herrero Carla Castignani Elizabeth Larose Cadieux Jonas Demeulemeester Peter Van Loo

Abstract B cells are frequently found in the margins of solid tumours as organized follicles ectopic lymphoid organs called tertiary structures (TLS) 1,2 . Although TLS have been to correlate with improved patient survival and response immune checkpoint blockade (ICB), underlying mechanisms this association remain elusive Here we investigate lung-resident cell responses patients from TRACERx 421 (Tracking Non-Small-Cell Lung Cancer Evolution Through Therapy) other lung cancer cohorts, a...

10.1038/s41586-023-05771-9 article EN cc-by Nature 2023-04-12
Maise Al Bakir Ariana Huebner Carlos Martínez‐Ruiz Kristiana Grigoriadis Thomas B.K. Watkins and 95 more Oriol Pich David A. Moore Selvaraju Veeriah Sophia Ward Joanne Laycock Diana Johnson Andrew Rowan Maryam Razaq Mita Akther Cristina Naceur‐Lombardelli Paulina Prymas Antonia Toncheva Sonya Hessey Michelle Dietzen Emma Colliver Alexander M. Frankell Abigail Bunkum Emilia L. Lim Takahiro Karasaki Christopher Abbosh Crispin T. Hiley Mark S. Hill Daniel E. Cook Gareth A. Wilson Roberto Salgado Emma Nye Richard Stone Dean A. Fennell Gillian Price Keith M. Kerr Babu Naidu Gary Middleton Yvonne Summers Colin R. Lindsay Fiona Blackhall Judith Cave Kevin G. Blyth Arjun Nair Asia Ahmed Magali N. Taylor Alexander James Procter Mary Falzon David Lawrence Neal Navani Ricky M. Thakrar Sam M. Janes Dionysis Papadatos-Pastos Martin Förster SM Lee Tanya Ahmad Sergio A. Quezada Karl S. Peggs Peter Van Loo Caroline Dive Allan Hackshaw Nicolai J. Birkbak Simone Zaccaria J.F. Lester Amrita Bajaj Apostolos Nakas Azmina Sodha-Ramdeen Keng Ang Mohamad Tufail Mohammed Fiyaz Chowdhry Molly Scotland Rebecca Boyles Sridhar Rathinam Claire Wilson Domenic Marrone Sean Dulloo Gurdeep Matharu Jacqui Shaw Joan Riley Lindsay Primrose Ekaterini Boleti Heather Cheyne Mohammed S. Khalil Shirley Richardson Tracey Cruickshank Sarah Benafif Kayleigh Gilbert Akshay J. Patel Aya Osman Christer Lacson Gerald Langman Helen Shackleford Madava Djearaman Salma Kadiri Angela Leek Jack Davies Hodgkinson Nicola Totten Ángeles Montero Elaine Smith Eustace Fontaine Felice Granato

Metastatic disease is responsible for the majority of cancer-related deaths

10.1038/s41586-023-05729-x article EN cc-by Nature 2023-04-12
Carlos Martínez‐Ruiz James R. Black Clare Puttick Mark S. Hill Jonas Demeulemeester and 95 more Elizabeth Larose Cadieux Kerstin Thol Thomas Peter Jones Selvaraju Veeriah Cristina Naceur‐Lombardelli Antonia Toncheva Paulina Prymas Andrew Rowan Sophia Ward Laura Cubitt Foteini Athanasopoulou Oriol Pich Takahiro Karasaki David A. Moore Roberto Salgado Emma Colliver Carla Castignani Michelle Dietzen Ariana Huebner Maise Al Bakir Miljana Tanić Thomas B.K. Watkins Emilia L. Lim Ali M. Al-Rashed Danny Lang James Clements Daniel E. Cook Rachel Rosenthal Gareth A. Wilson Alexander M. Frankell Sophie de Carné Trécesson Philip East Nnennaya Kanu Kevin Litchfield Nicolai J. Birkbak Allan Hackshaw Stephan Beck Peter Van Loo Mariam Jamal‐Hanjani Nicholas McGranahan Charles Swanton Maise Al Bakir Emilia L. Lim Alexander M. Frankell Kevin Litchfield Nicolai J. Birkbak Peter Van Loo J.F. Lester Amrita Bajaj Apostolos Nakas Azmina Sodha-Ramdeen Keng Ang Mohamad Tufail Mohammed Fiyaz Chowdhry Molly Scotland Rebecca Boyles Sridhar Rathinam Claire Wilson Domenic Marrone Sean Dulloo Dean A. Fennell Gurdeep Matharu Jacqui Shaw Joan Riley Lindsay Primrose Ekaterini Boleti Heather Cheyne Mohammed S. Khalil Shirley Richardson Tracey Cruickshank Gillian Price Keith M. Kerr Sarah Benafif Kayleigh Gilbert Babu Naidu Akshay J. Patel Aya Osman Christer Lacson Gerald Langman Helen Shackleford Madava Djearaman Salma Kadiri Gary Middleton Angela Leek Jack Davies Hodgkinson Nicola Totten Ángeles Montero Elaine Smith Eustace Fontaine Felice Granato Helen Doran Juliette Novasio Kendadai Rammohan Leena Dennis Joseph Paul N. Bishop

Abstract Intratumour heterogeneity (ITH) fuels lung cancer evolution, which leads to immune evasion and resistance therapy 1 . Here, using paired whole-exome RNA sequencing data, we investigate intratumour transcriptomic diversity in 354 non-small cell tumours from 347 out of the first 421 patients prospectively recruited into TRACERx study 2,3 Analyses 947 tumour regions, representing both primary metastatic disease, alongside 96 tumour-adjacent normal tissue samples implicate transcriptome...

10.1038/s41586-023-05706-4 article EN cc-by Nature 2023-04-12
Yin Wu Dhruva Biswas Ieva Usaite Mihaela Angelova Stefan Boeing and 95 more Takahiro Karasaki Selvaraju Veeriah Justyna Czyzewska-Khan Cienne Morton Magdalene Joseph Sonya Hessey James L. Reading Andrew Georgiou Maise Al-Bakir Nicolai J. Birkbak Gillian Price Mohammed S. Khalil Keith M. Kerr Shirley Richardson Heather Cheyne Tracey Cruickshank Gareth A. Wilson Rachel Rosenthal Hugo J.W.L. Aerts Madeleine Hewish Girija Anand Sajid Khan Kelvin Lau Michael Sheaff Peter Schmid Louise Lim John Conibear Roland F. Schwarz Tom L. Kaufmann Matthew R. Huska Jacqui Shaw Joan Riley Lindsay Primrose Dean A. Fennell Allan Hackshaw Yenting Ngai Abigail Sharp Oliver Pressey Sean Smith Nicole Gower Harjot Kaur Dhanda Kitty S. Chan Sonal Chakraborty Kevin Litchfield Krupa Thakkar Jonathan Tugwood Alexandra Clipson Caroline Dive Dominic G. Rothwell Alastair Kerr Elaine Kilgour Fiona J. E. Morgan Malgorzata Kornaszewska Richard Attanoos Helen Davies Katie Baker Mathew Carter Colin R. Lindsay Fábio Gomes Fiona Blackhall Lynsey Priest Matthew Krebs Anshuman Chaturvedi Pedro Oliveira Zoltán Szállási Gary Royle Catarina Veiga Marcin Skrzypski Roberto Salgado Miklós Dióssy Alan Kirk Mo Asif John Butler Rocco Bilancia Nikos Kostoulas Mathew Thomas Mairead MacKenzie Maggie Wilcox Apostolos Nakas Sridhar Rathinam Rebecca Boyles Mohamad Tufail Amrita Bajaj Keng Ang Mohammed Fiyaz Chowdhry Michael Shackcloth Julius Asante-Siaw Angela Leek Nicola Totten Jack Davies Hodgkinson Peter Van Loo William Monteiro Hilary Marshal Kevin G. Blyth Craig Dick

Abstract Murine tissues harbor signature γδ T cell compartments with profound yet differential impacts on carcinogenesis. Conversely, human tissue-resident cells are less well defined. In the present study, we show that lung a resident Vδ1 population. Moreover, demonstrate memory and effector phenotypes were enriched in tumors compared nontumor tissues. Intratumoral possessed stem-like features skewed toward cytolysis helper type 1 function, akin to intratumoral natural killer CD8 +...

10.1038/s43018-022-00376-z article EN cc-by Nature Cancer 2022-05-30
Takahiro Karasaki David A. Moore Selvaraju Veeriah Cristina Naceur‐Lombardelli Antonia Toncheva and 95 more Neil Magno Sophia Ward Maise Al Bakir Thomas B.K. Watkins Kristiana Grigoriadis Ariana Huebner Mark S. Hill Alexander M. Frankell Christopher Abbosh Clare Puttick Hao-Ran Zhai Francisco Gimeno-Valiente Sadegh Saghafinia Nnennaya Kanu Michelle Dietzen Oriol Pich Emilia L. Lim Carlos Martínez‐Ruiz James R. Black Dhruva Biswas Brittany Campbell Claudia Lee Emma Colliver Katey S.S. Enfield Sonya Hessey Crispin T. Hiley Simone Zaccaria Kevin Litchfield Nicolai J. Birkbak Elizabeth Larose Cadieux Jonas Demeulemeester Peter Van Loo Prasad S. Adusumilli Kay See Tan Waseem Cheema Francisco Sánchez-Vega David R. Jones Natasha Rekhtman William D. Travis Allan Hackshaw Teresa Marafioti Roberto Salgado John Le Quesne Andrew G. Nicholson Peter Van Loo John Le Quesne J.F. Lester Amrita Bajaj Apostolos Nakas Azmina Sodha-Ramdeen Keng Ang Mohamad Tufail Mohammed Fiyaz Chowdhry Molly Scotland Rebecca Boyles Sridhar Rathinam Claire Wilson Domenic Marrone Sean Dulloo Dean A. Fennell Gurdeep Matharu Jacqui Shaw Joan Riley Lindsay Primrose Ekaterini Boleti Heather Cheyne Mohammed S. Khalil Shirley Richardson Tracey Cruickshank Gillian Price Keith M. Kerr Sarah Benafif Kayleigh Gilbert Babu Naidu Akshay J. Patel Aya Osman Christer Lacson Gerald Langman Helen Shackleford Madava Djearaman Salma Kadiri Gary Middleton Angela Leek Jack Davies Hodgkinson Nicola Totten Ángeles Montero Elaine Smith Eustace Fontaine Felice Granato Helen Doran Juliette Novasio Kendadai Rammohan Leena Dennis Joseph Paul N. Bishop Rajesh Shah

10.1038/s41591-023-02230-w article EN Nature Medicine 2023-04-01
Othman Al‐Sawaf Jakob Weiss Marcin Skrzypski Jie Min Lam Takahiro Karasaki and 95 more Francisco Zambrana Andrew Kidd Alexander M. Frankell Thomas B.K. Watkins Carlos Martínez‐Ruiz Clare Puttick James R. Black Ariana Huebner Maise Al Bakir Mateo Sokač Susie M. Collins Selvaraju Veeriah Neil Magno Cristina Naceur‐Lombardelli Paulina Prymas Antonia Toncheva Sophia Ward Nick Jayanth Roberto Salgado Christopher P. Bridge David C. Christiani Raymond H. Mak Camden P. Bay Michael H. Rosenthal Naveed Sattar Paul Welsh Ying Liu Norbert Perrimon Karteek Popuri Mirza Faisal Beg Nicholas McGranahan Allan Hackshaw Danna M. Breen Stephen O’Rahilly Nicolai J. Birkbak Hugo J.W.L. Aerts Thomas B.K. Watkins Nicolai J. Birkbak Hugo J.W.L. Aerts J.F. Lester Amrita Bajaj Apostolos Nakas Azmina Sodha-Ramdeen Keng Ang Mohamad Tufail Mohammed Fiyaz Chowdhry Molly Scotland Rebecca Boyles Sridhar Rathinam Claire Wilson Domenic Marrone Sean Dulloo Dean A. Fennell Gurdeep Matharu Jacqui Shaw Joan Riley Lindsay Primrose Ekaterini Boleti Heather Cheyne Mohammed Khalil Shirley Richardson Tracey Cruickshank Gillian Price Keith M. Kerr Sarah Benafif Kayleigh Gilbert Babu Naidu Akshay J. Patel Aya Osman Christer Lacson Gerald Langman Helen Shackleford Madava Djearaman Salma Kadiri Gary Middleton Angela Leek Jack Davies Hodgkinson Nicola Totten Ángeles Montero Elaine Smith Eustace Fontaine Felice Granato Helen Doran Juliette Novasio Kendadai Rammohan Leena Dennis Joseph Paul N. Bishop Rajesh Shah Stuart Moss Vijay Joshi Philip Crosbie Fábio Gomes Kate Brown Mathew Carter Anshuman Chaturvedi

10.1038/s41591-023-02232-8 article EN Nature Medicine 2023-04-01

Abstract Understanding the role of tumor microenvironment (TME) in lung cancer is critical to improving patient outcomes. We identified four histology-independent archetype TMEs treatment-naïve early-stage using imaging mass cytometry TRACERx study (n = 81 patients/198 samples/2.3 million cells). In immune-hot adenocarcinomas, spatial niches T cells and macrophages increased with clonal neoantigen burden, whereas such an increase was observed for plasma B immune-excluded squamous cell...

10.1158/2159-8290.cd-23-1380 article EN cc-by Cancer Discovery 2024-04-06
James R. Black Gábor Bartha Charles W. Abbott Sean Michael Boyle Takahiro Karasaki and 95 more Bailiang Li Rui Chen Jason Harris Selvaraju Veeriah Marzia Colopi Maise Al Bakir Wing Kin Liu John Lyle Fábio C. P. Navarro Josette Northcott Rachel Marty Pyke Mark S. Hill Kerstin Thol Ariana Huebner Chris Bailey Emma Colliver Carlos Martínez‐Ruiz Kristiana Grigoriadis Piotr Pawlik David A. Moore Daniele Marinelli Oliver G. Shutkever Cian Murphy Monica Sivakumar J.F. Lester Amrita Bajaj Apostolos Nakas Azmina Sodha-Ramdeen Mohamad Tufail Molly Scotland Rebecca Boyles Sridhar Rathinam Claire Wilson Domenic Marrone Sean Dulloo Dean A. Fennell Gurdeep Matharu Ekaterini Boleti Heather Cheyne Mohammed Khalil Shirley Richardson Tracey Cruickshank Gillian Price Keith M. Kerr Sarah Benafif Jack French Kayleigh Gilbert Babu Naidu Akshay J. Patel Aya Osman Carol Enstone Gerald Langman Helen Shackleford Madava Djearaman Salma Kadiri Gary Middleton Angela Leek Jack Davies Hodgkinson Nikki Totton Ángeles Montero Elaine Smith Eustace Fontaine Felice Granato António Paiva‐Correia Juliette Novasio Kendadai Rammohan Leena Dennis Joseph Paul Bishop Rajesh Shah Stuart Moss Vijay Joshi Philip Crosbie Katherine D. Brown Mathew Carter Anshuman Chaturvedi Pedro Oliveira Colin R. Lindsay Fiona Blackhall Matthew Krebs Yvonne Summers Alexandra Clipson Jonathan Tugwood Alastair Kerr Dominic G. Rothwell Caroline Dive Hugo J.W.L. Aerts Roland F. Schwarz Tom L. Kaufmann Gareth A. Wilson Rachel Rosenthal Peter Van Loo Nicolai J. Birkbak Zoltán Szállási Judit Kisistók Mateo Sokač

Abstract Circulating tumor DNA (ctDNA) detection can predict clinical risk in early-stage tumors. However, applications are constrained by the sensitivity of clinically validated ctDNA approaches. NeXT Personal is a whole-genome-based, tumor-informed platform that has been analytically for ultrasensitive at 1–3 ppm with 99.9% specificity. Through an analysis 171 patients lung cancer from TRACERx study, we detected pre-operatively within 81% adenocarcinoma (LUAD), including 53% those...

10.1038/s41591-024-03216-y article EN cc-by Nature Medicine 2025-01-13
Robert Bentham Thomas P. Jones James R. Black Carlos Martínez‐Ruiz Michelle Dietzen and 95 more Maria Litovchenko Kerstin Thol Thomas B.K. Watkins C. Bailey Oriol Pich Zhihui Zhang Peter Van Loo Mariam Jamal‐Hanjani Carlos Martínez‐Ruiz Peter Van Loo James R. Black Takahiro Karasaki Abigail Bunkum Sonya Hessey Wing Kin Liu Nicolai J. Birkbak Alexander M. Frankell Ariana Huebner Clare Puttick Crispin T. Hiley David Moore Dhruva Biswas Emilia L. Lim Kristiana Grigoriadis Maise Al Bakir Olivia Lucas Roberto Vendramin Sophia Ward S. Harries Simone Zaccaria Rija Zaidi Lucrezia Patruno Despoina Karagianni Sergio A. Quezada Supreet Kaur Bola Martin Förster Siow Ming Lee Corentin Richard Cristina Naceur‐Lombardelli Francisco Gimeno-Valiente Krupa Thakkar Monica Sivakumar Nnennaya Kanu Ieva Usaite Sadegh Saghafinia Selvaraju Veeriah Sharon Vanloo Antonia Toncheva Paulina Prymas Bashair M. Mussa Michalina Magala Elizabeth Keene Michelle Leung Gareth A. Wilson Rachel Rosenthal Andrew Rowan Claudia Lee Emma Colliver Katey S.S. Enfield Mihaela Angelova Cian Murphy Maria Zagorulya Teresa Marafioti Elaine Borg Mary Falzon Reena Khiroya Yien Ning Sophia Wong Emilie Martinoni Hoogenboom Fleur Monk James W. Holding Junaid Choudhary Kunal Bhakhri Pat Gorman Robert Stephens Maria Chiara Pisciella Steve Bandula Jérôme Nicod Angela Dwornik Angeliki Karamani Benny Chain David R. Pearce Georgia Stavrou Gerasimos-Theodoros Mastrokalos Helen L. Lowe James L. Reading John A. Hartley Kayalvizhi Selvaraju Leah Ensell Mansi Shah Piotr Pawlik Samuel Gamble Seng Kuong Anakin Ung Victoria J. Spanswick Yin Wu J.F. Lester

Abstract Recognition and elimination of pathogens cancer cells depend on the adaptive immune system. Thus, accurate quantification subsets is vital for precision medicine. We present lymphocyte estimation from nucleotide sequencing (ImmuneLENS), which estimates T cell B fractions, class switching clonotype diversity whole-genome data at depths as low 5× coverage. By applying ImmuneLENS to 100,000 Genomes Project, we identify genes enriched with somatic mutations in cell-rich tumors,...

10.1038/s41588-025-02086-5 article EN cc-by Nature Genetics 2025-02-18
Coming Soon ...