A5039804528- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- MicroRNA in disease regulation
- Breast Cancer Treatment Studies
- Radiomics and Machine Learning in Medical Imaging
- Molecular Biology Techniques and Applications
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Genetic Syndromes and Imprinting
- Lung Cancer Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Cancer Cells and Metastasis
- Gene expression and cancer classification
- Immunotherapy and Immune Responses
- Cancer-related gene regulation
- Cancer Immunotherapy and Biomarkers
- Pancreatic and Hepatic Oncology Research
- Cancer-related Molecular Pathways
- Wnt/β-catenin signaling in development and cancer
- Colorectal Cancer Screening and Detection
- Immune Cell Function and Interaction
- Heat shock proteins research
- T-cell and B-cell Immunology
University College London
2016-2025
London Cancer
2018-2025
Genomics (United Kingdom)
2018-2025
The London College
2022-2025
CRUK Lung Cancer Centre of Excellence
2016-2024
Oncology Institute of Vojvodina
2013-2024
Institut za onkologiju i radiologiju Srbije
2022
Cancer Institute (WIA)
2021
Cancer Research UK
2020
Spanish National Cancer Research Centre
2011-2014
Abstract Intratumour heterogeneity (ITH) fuels lung cancer evolution, which leads to immune evasion and resistance therapy 1 . Here, using paired whole-exome RNA sequencing data, we investigate intratumour transcriptomic diversity in 354 non-small cell tumours from 347 out of the first 421 patients prospectively recruited into TRACERx study 2,3 Analyses 947 tumour regions, representing both primary metastatic disease, alongside 96 tumour-adjacent normal tissue samples implicate transcriptome...
Aberrant miRNA expression has been previously established in breast cancer and clinical relevance. However, no studies so far have defined miRNAs deregulated hereditary tumors. In this study we investigated the role of tumors comparing with normal tissue. Global profiling using Exiqon microarrays was performed on 22 15 non-tumoral tissues. We identified 19 differentially expressed, most them down-regulated An important proportion were commonly sporadic Under-expression these validated by...
Screening for germline mutations in breast cancer-associated genes BRCA1 and BRCA2 is indicated patients with cancer from high-risk families influences both treatment options clinical management. However, only 25% of selected test positive BRCA1/2 mutation, indicating that additional diagnostic biomarkers are necessary. We analyzed 124 formalin-fixed paraffin-embedded (FFPE) tumor samples hereditary (104) sporadic (20) invasive cancer, divided into two series (A B). Microarray expression...
Lung TRACERx is a prominent study employing multi-region and longitudinal multi-omics sequencing to unravel the evolutionary trajectories of cancer. While aberrant DNA methylation described in most cancers, its interplay with genomic alterations chromatin remodeling non-small cell lung cancer (NSCLC) less understood. We propose Allosteric Chromatin Activity Transition (AllChAT) as framework elucidate epigenetic dosage compensation mechanisms, focusing on essential genes impacted by...
Hereditary breast cancer comprises 5–10% of all cancers. Mutations in two high-risk susceptibility genes, BRCA1 and BRCA2, along with rare intermediate-risk genes common low-penetrance alleles identified, altogether explain no more than 45% the families, although majority cases are unaccounted for designated as BRCAX tumours. Micro RNAs have called great attention classification different types been implicated a range important biological processes deregulated pathogenesis. Here we performed...
Radiation therapy is an indispensable part of various treatment modalities for breast cancer. Specifically, non-inflammatory locally advanced cancer (LABC) patients, preoperative radiotherapy (pRT) currently indicated as a second line in the event lack response to neoadjuvant chemotherapy. Still approximately one third patients fails respond favourably pRT. The aim this study was explore molecular mechanisms underlying differential (RT) identify predictive biomarkers and potential targets...
Epigenetic heterogeneity within a tumour can play an important role in evolution and the emergence of resistance to treatment. It is increasingly recognised that study DNA methylation (DNAm) patterns along genome – so-called ‘epialleles’ offers greater insight into epigenetic dynamics than conventional analyses which examine DNAm marks individually. We have developed Bayesian model infer epialleles are present multiple regions same tumour. apply our method reduced representation bisulfite...
Hereditary breast cancer constitutes only 5-10% of all cases and is characterized by strong family history and/or other associated types. Only ~ 25% hereditary carry a mutation in BRCA1 or BRCA2 gene, while mutations rare high moderate-risk genes common low penetrance variants may account for additional 20% the cases. Thus majority are still unaccounted designated as BRCAX tumors. MicroRNAs small non-coding RNAs that play important roles regulators gene expression deregulated cancer. To...
It is projected that, by 2040, the number of new cases colorectal cancer (CRC) will increase to 3.2 million, and deaths 1.6 highlighting need for prevention strategies, early detection adequate follow-up. In this study, we aimed provide an overview progress in personalized medicine CRC Serbia, with results insights from Institute Oncology Radiology Serbia (IORS), propose guidance tackling observed challenges future.
Papillary thyroid carcinoma (PTC) is generally considered an indolent cancer. However, patients with cervical lymph node metastasis (LNM) have a higher risk of local recurrence. This study evaluated and compared four machine learning (ML)-based classifiers to predict the presence LNM in clinically node-negative (cN0) T1 T2 PTC patients. The algorithm was developed using clinicopathological data from 288 who underwent total thyroidectomy prophylactic central neck dissection, sentinel biopsy...
The use tumor-derived cell-free DNA extracted from body fluids is being evaluated for genetic testing in lung cancer. aim of this study was to explore the feasibility and utility implementation EGFR molecular pleural effusions non-small cell cancer clinical diagnostics workflow.This included patients diagnosed with primary adenocarcinoma period July 2016 June 2023. mutation performed by qPCR (Cobas®) dPCR. Testing 211 plasma samples when tissue unavailable at diagnosis, 301 18 progression on...
SUMMARY Aberrant methylation is a hallmark of cancer, but bulk tumor data confounded by admixed normal cells and copy number changes. Here, we introduce Copy number-Aware Methylation Deconvolution Analysis Cancers (CAMDAC; https://github.com/VanLoo-lab/CAMDAC ), which outputs purity, allele-specific deconvolved estimates. We apply CAMDAC to 122 multi-region samples from 38 TRACERx non-small cell lung cancers profiled reduced representation bisulfite sequencing. profiles parallel those...