A5081389327- Breast Cancer Treatment Studies
- Cancer Treatment and Pharmacology
- HER2/EGFR in Cancer Research
- Advanced Breast Cancer Therapies
- Cancer Risks and Factors
- Bioinformatics and Genomic Networks
- Estrogen and related hormone effects
- Computational Drug Discovery Methods
- Cancer Genomics and Diagnostics
- Ubiquitin and proteasome pathways
- Reproductive Biology and Fertility
- Gene expression and cancer classification
- Ovarian cancer diagnosis and treatment
- Cancer Diagnosis and Treatment
- BRCA gene mutations in cancer
- Breast Lesions and Carcinomas
- Lung Cancer Treatments and Mutations
- Chemotherapy-related skin toxicity
- Cancer survivorship and care
- PI3K/AKT/mTOR signaling in cancer
- Ferroptosis and cancer prognosis
- Monoclonal and Polyclonal Antibodies Research
- Childhood Cancer Survivors' Quality of Life
- Histone Deacetylase Inhibitors Research
- Male Breast Health Studies
Oncology Institute of Vojvodina
2016-2025
International Breast Cancer Study Group
2021
Patient-Centered Outcomes Research Institute
2021
Australia New Zealand Gynaecological Oncology Group
2011
Hallym University Sacred Heart Hospital
2011
Institut za onkologiju i radiologiju Srbije
2002-2007
Prospective data on the risk of recurrence among women with hormone receptor–positive early breast cancer who temporarily discontinue endocrine therapy to attempt pregnancy are lacking. Download a PDF Research Summary. We conducted single-group trial in which we evaluated temporary interruption adjuvant young previous cancer. Eligible were 42 years age or younger; had stage I, II, III disease; received for 18 30 months; and desired pregnancy. The primary end point was number events (defined...
•Final safety and efficacy results from PERUSE with ∼6 years' median follow-up are consistent CLEOPATRA results.•Results provide reassurance that paclitaxel is a valid alternative to docetaxel first-line pertuzumab trastuzumab.•In exploratory analyses, presence of both visceral disease prior trastuzumab identified subgroup worse PFS. BackgroundThe phase III CLinical Evaluation Of Pertuzumab And TRAstuzumab (CLEOPATRA) trial established the combination pertuzumab, as standard therapy for...
We investigated time to pregnancy, efficacy and safety of fertility preservation, assisted reproductive technologies (ARTs) in women with early hormone receptor-positive breast cancer (BC) desiring future pregnancy.
Premenopausal women with early hormone-receptor positive (HR+) breast cancer receive 5-10 years of adjuvant endocrine therapy (ET) during which pregnancy is contraindicated and fertility may wane. The POSITIVE study investigates the impact temporary ET interruption to allow pregnancy.POSITIVE enrolled stage I-III HR + cancer, ≤42 years, who had received 18-30 months wished interrupt for pregnancy. Treatment up 2 was permitted pregnancy, delivery breastfeeding, followed by resumption complete...
ESMO COVID-19 and CAncer REgistry (ESMO-CoCARE) is an international collaborative registry-based, cohort study gathering real-world data from Europe, Asia/Oceania Africa on the natural history, management outcomes of patients with cancer infected severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).
Background/Objectives: Triple-negative breast cancer (TNBC) is characterized by the absence of expression estrogen receptors, progesterone and human epidermal growth factor receptor 2. As there are no specific targeted therapies, TNBC patients often face an aggressive clinical course. The androgen (AR) has been found in up to 30% cases, but association between AR status survival rates remains controversial. aim this study was explore with disease outcome early within a 5-year follow-up....
Tamoxifen is a standard therapeutical treatment in patients with estrogen receptor positive breast carcinoma. However, less than 50% of cancers do not respond to tamoxifen whereas 40% tumors that initially develop resistance over time. The underlying mechanisms for are probably multifactorial but remain largely unknown. primary aim this study was investigate the impact PTEN tumor suppressor gene on acquiring by analyzing loss heterozygosity (LOH) and immunohystochemical expression 49...
Abstract Background: Pregnancy after breast cancer (BC) is of substantial importance for many young women at diagnosis and during follow-up. BC treatment including standard endocrine therapy (ET) (5-10 years) may reduce ovarian reserve the chances subsequent successful pregnancy, given conception contraindicated ET. A temporary interruption ET to attempt carry a pregnancy in this population has never been prospectively studied. Methods: POSITIVE single-arm, prospective,...
Gastrointestinal metastases from invasive lobular breast cancer are uncommon with the stomach and small intestines being most common metastatic sites. Peritoneal rectal very rare only rarely occur as first manifestation of disease. We herein report case a 47-year-old woman who presented abdominal carcinomatosis sign carcinoma (ILC). Identifying important immunohistochemical markers for ILC: gross cystic disease fluid protein 15, estrogen progesterone receptors enabled correct diagnosis....
Abstract Introduction The addition of taxanes to anthracycline-based chemotherapy is considered standard care in the treatment breast cancer. However, there are insufficient data regarding safety during pregnancy. aim this study was describe incidence obstetric and neonatal adverse events associated with use taxane-containing regimens for cancer Methods This a multicenter, international cohort patients treated A descriptive analysis undertaken synthetize available data. Results total 103...
This retrospective study was undertaken in order to assess the prognostic value of prechemotherapy serum CA125 level, kinetics, and half-life compared ten common clinicopathological variables patients with advanced ovarian cancer (AOC). levels were determined before during induction cisplatin polychemotherapy 222 patients. A level higher than 35 U/mL found 134 Blood samples further obtained each course chemotherapy (CT). values calculated 112 above 60 using van der Burg's exponential...
The binding of spin-labeled fatty acids (SLFAs) to the human serum albumin (HSA) examined by electron paramagnetic resonance (EPR) spectroscopy was studied evaluate potential HSA/SLFA/EPR technique as a biomarking tool for cancer. A comparative study performed on two spin labels with nitroxide groups attached at opposite ends acid (FA) chain, 5-doxyl stearic (5-DS) and 16-doxyl (16-DS) acid. effects incubation time, different [SLFA]/[HSA] molar ratios, ethanol, temperature showed that...
The aim of this study was to evaluate the prognostic potential urokinase-type plasminogen activator (uPA) and inhibitor type 1 (PAI-1) tumor tissue levels examine association between these biomarkers classical factors in early node-negative luminal breast cancer patients. clinical value 4G/5G variants PAI-1 gene evaluated. This involved 81 node-negative, estrogen receptor-positive and/or progesterone human epidermal growth factor receptor 2-negative operable patients who underwent radical...
The aim of our study was to explore a potential analgesic effect gabapentin in patients with neuropathic pain caused by anticancer treatment. A total 23 outpatients without active disease and chronic, treatment-related were included this single-center, open-label, exploratory, non-controlled study. primary end-points intensity relief following 4-week treatment period. 15 (65%) completed the study, 5 (22%) discontinued due failure 3 (13%) toxicity. More than 50% reduction obtained 11 (48%,...
Radiation therapy is an indispensable part of various treatment modalities for breast cancer. Specifically, non-inflammatory locally advanced cancer (LABC) patients, preoperative radiotherapy (pRT) currently indicated as a second line in the event lack response to neoadjuvant chemotherapy. Still approximately one third patients fails respond favourably pRT. The aim this study was explore molecular mechanisms underlying differential (RT) identify predictive biomarkers and potential targets...
Regular physical activity and exercise improves quality of life possibly reduces risk disease relapse prolongs survival in breast cancer survivors. The aim this study was to evaluate the impact a 3-week moderate intensity aerobic training, on capacity (VO2max) survivors.A prospective, randomized clinical included 18 female survivors stage I-IIIA, which primary treatment accomplished at least 3 months before inclusion. In all patients VO2max estimated using Astrand's protocol...
Summary Background: Breast cancer is the most common form of in women. It arises from multiple genetic changes oncogenes and tumor suppressor genes. Among so far studied relatively few, including epdermal growth factor receptor (EGFR), cyclinD1 (CCND1)and cmyc, have been found to play an important role progression this type human malignancy. The aim study was examine prognostic potential CCND1, c-myc EGFR amplification their possible cooperation breast carcinogenesis. Methods: Copy number...
Triple-negative breast cancers (TNBC) are resistant to standard-of-care chemotherapy and lack known targetable driver gene alterations. Identification of novel drivers could aid the discovery new treatment strategies for this hard-to-treat patient population, yet studies using high-throughput accurate models define functions genes in TNBC date have been limited. Here, we employed unbiased functional genomics screening 200 most frequently mutated cancer, spheroid cultures model
Triple negative breast cancer (TNBC) is characterized by aggressive clinical course and unresponsive to anti-HER2 endocrine therapy. TNBC difficult treat often lethal. Given the need find new targets for therapy we explored clinicopathological significance of copy number gain FGFR1 c-MYC. Our aim was determine impact c-MYC on outcome TNBC.FGFR1 gene alterations were evaluated in 78 archive samples using TaqMan based quantitative real time PCR assays.50% had increased number. associated with...
Background: Differential expressions of cancer-associated genes, including histone deacetylases (HDACs), were identified in distinctive molecular subtypes breast cancer. Compared with hormone receptor-positive cancer, triple-negative (TNBC, ER−PR−HER2−) is the most aggressive form Aims: To determine association HDAC7 mRNA expression levels clinicopathological features and patients' survival TNBC or ER+PR+HER2− cancers. Methods: Total RNA was extracted from 61 74 ER+PR+Her2− tumors. Relative...