Radoslav Davidović
A5038618256- Bioinformatics and Genomic Networks
- Sarcoma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Protein Structure and Dynamics
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Machine Learning in Bioinformatics
- Enzyme Structure and Function
- Bone Tumor Diagnosis and Treatments
- Microbial Natural Products and Biosynthesis
- RNA and protein synthesis mechanisms
- MicroRNA in disease regulation
- Oral and Maxillofacial Pathology
- Advanced Proteomics Techniques and Applications
- Circular RNAs in diseases
- Genomics and Phylogenetic Studies
- Oral and gingival health research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Spine and Intervertebral Disc Pathology
- Genomics and Rare Diseases
- Organ Donation and Transplantation
- Parasitic Infections and Diagnostics
- Mass Spectrometry Techniques and Applications
- Genomics and Chromatin Dynamics
- Neurological Disorders and Treatments
University of Belgrade
2012-2021
Vinča Institute of Nuclear Sciences
2016-2018
Laboratory of Molecular Genetics
2012
Abstract Background The Critical Assessment of Functional Annotation (CAFA) is an ongoing, global, community-driven effort to evaluate and improve the computational annotation protein function. Results Here, we report on results third CAFA challenge, CAFA3, that featured expanded analysis over previous rounds, both in terms volume data analyzed types performed. In a novel major new development, predictions assessment goals drove some experimental assays, resulting functional annotations for...
Intrinsically disordered proteins, defying the traditional protein structure-function paradigm, are a challenge to study experimentally. Because large part of our knowledge rests on computational predictions, it is crucial that their accuracy high. The Critical Assessment Intrinsic Disorder prediction (CAID) experiment was established as community-based blind test determine state art in intrinsically regions and subset residues involved binding. A total 43 methods were evaluated dataset 646...
The Database of Protein Disorder (DisProt, URL: www.disprot.org) has been significantly updated and upgraded since its last major renewal in 2007. current release holds information on more than 800 entries IDPs/IDRs, i.e. intrinsically disordered proteins or regions that exist function without a well-defined three-dimensional structure. We have re-curated previous to purge DisProt from conflicting cases, also the functional classification scheme reflect continuous advance field past 10 years...
Abstract The Database of Protein Disorder (DisProt, URL: https://disprot.org) provides manually curated annotations intrinsically disordered proteins from the literature. Here we report recent developments with DisProt (version 8), including doubling protein entries, a new disorder ontology, improvements annotation format and completely website. website includes redesigned graphical interface, better search engine, clearer API for programmatic access interface that integrates text mining...
Abstract The Database of Intrinsically Disordered Proteins (DisProt, URL: https://disprot.org) is the major repository manually curated annotations intrinsically disordered proteins and regions from literature. We report here recent updates DisProt version 9, including a restyled web interface, refactored Ontology (IDPO), improvements in curation process significant content growth around 30%. Higher quality consistency provided by newly implemented reviewing training curators. increased...
Abstract The Critical Assessment of Functional Annotation (CAFA) is an ongoing, global, community-driven effort to evaluate and improve the computational annotation protein function. Here we report on results third CAFA challenge, CAFA3, that featured expanded analysis over previous rounds, both in terms volume data analyzed types performed. In a novel major new development, predictions assessment goals drove some experimental assays, resulting functional annotations for more than 1000...
Tamoxifen is a standard therapeutical treatment in patients with estrogen receptor positive breast carcinoma. However, less than 50% of cancers do not respond to tamoxifen whereas 40% tumors that initially develop resistance over time. The underlying mechanisms for are probably multifactorial but remain largely unknown. primary aim this study was investigate the impact PTEN tumor suppressor gene on acquiring by analyzing loss heterozygosity (LOH) and immunohystochemical expression 49...
X-chromosome instability has been a long established feature in Alzheimer's disease (AD). Premature centromere division and aneuploidy of the found peripheral blood lymphocytes neuronal tissue female AD patients. Interestingly, only one chromosome X pair affected. These results raised question, "Is inactivation pattern altered women affected by AD?" To address this we analyzed methylation status androgen receptor promoter which may show us any deviation from 50 : 50% with AD. Our showed...
Abstract Methylation-specific PCR (MSP) is still the method of choice for a single gene methylation study. The proper design primer pairs prerequisite obtaining reliable results. Despite numerous protocols describing rules MSP design, none them provide comprehensive approach to problem. Our aim was depict workflow that concise and easy follow. In order achieve this goal, adequate tools promoter sequence retrieval, subsequent in silico analysis are presented discussed. Furthermore, few...
Although various tools for Gene Ontology (GO) term enrichment analysis are available, there is still room improvement. Hence, we present DiNGO, a standalone application based on an open source code from BiNGO, widely-used to assess the overrepresentation of GO categories. Besides facilitating analyses, DiNGO has been developed allow convenient Human Phenotype (HPO) investigation. This important contribution considering increasing interest in HPO scientific research and its potential clinical...
Rhabdomyosarcoma (RMS) is a highly malignant cancer.Over the last two decades, prognosis for RMS patients has significantly improved, with exception of those in high-risk group.In order to identify new prognostic factors, we investigated expression nestin cells and its correlation clinicopathological features patient outcome.The analysis overall survival all (N = 30) revealed 1-, 2-, 3-, 4-, 5-year rates 93.3, 83.3, 66.7, 63.3, 63.3%, respectively.Nestin overexpression correlated (P...
Rhabdomyosarcoma (RMS) is a highly malignant cancer and the most common soft tissue sarcoma in children adolescents, but it rare adults (<1% of all adult malignancies). Altered expression molecular abnormalities cell-cycle-regulatory proteins are one prominent features RMS. Therefore, we evaluated cyclin-dependent kinase inhibitors p57 p16, as well p16 methylation status, along with clinicopathological characteristics overall survival (OS) RMS patients. This analysis was conducted on 23...
Methylation of p16 and p14 genes is a common event in colorectal cancers; however, their exact role the prediction patients? outcome unclear. We conducted this retrospective study to evaluate potential predictive and/or prognostic roles. Methylation-specific PCR was used examine methylation status pretherapeutic preoperative biopsy specimens 60 patients with locally advanced rectal cancer. The examined did not affect response chemoradiotherapy (CRT), recurrence rate overall survival....
Aim of the study is to determine possible roles p53, cyclin D1, β-catenin and Ki-67 in increase risk fractures patients with giant cell tumor bone. The included a total 164 bone (GCTB), 21 (12.8%) 143 (87.2%) without fracture. samples were analyzed immunohistochemically for expression Ki-67, D1 β-catenin. According immunohistochemical p53 Ki 67 mononuclear stromal cells, as well multinuclear there was no significant association immunopositivity fractures. However, our research revealed that...