A5007533342- Estrogen and related hormone effects
- HER2/EGFR in Cancer Research
- TGF-β signaling in diseases
- Breast Cancer Treatment Studies
- Chemokine receptors and signaling
- Protease and Inhibitor Mechanisms
- Cancer Genomics and Diagnostics
- Monoclonal and Polyclonal Antibodies Research
- Cancer Cells and Metastasis
- Cytokine Signaling Pathways and Interactions
- Angiogenesis and VEGF in Cancer
- Bone health and treatments
- Pancreatic and Hepatic Oncology Research
- Gene expression and cancer classification
- Cell Adhesion Molecules Research
- Metabolism, Diabetes, and Cancer
- AI in cancer detection
- Molecular Biology Techniques and Applications
- Cancer Treatment and Pharmacology
- Cancer, Hypoxia, and Metabolism
- Inflammatory mediators and NSAID effects
- Cancer, Lipids, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- Cell Image Analysis Techniques
Oncology Institute of Vojvodina
2012-2025
University of Calgary
2012
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
2012
Tissue expressed human epidermal growth factor receptor 2 (HER2) is an established parameter of breast cancer, and it determined in routine clinical practice by histology. This study aims to assess the prognostic value serum HER2 protein quantified using ELISA 66 primary cancer patients. The median follow-up period was 94 months. Prognostic performance assessed through receiver operating characteristic (ROC), Cox proportional hazards regression, Kaplan-Meier analyses. There a significant...
BACKGROUND: Cancer progression and metastasis are complex processes, dependent of molecules involved in inflammation, degradation invasion. These can be used as prognostic indicators to single out patients with higher risk recurrenc
Survival and life quality of breast cancer patients could be improved by more aggressive chemotherapy for those at high metastasis risk less intense treatments low-risk patients. Such personalized treatment cannot currently achieved due to the insufficient reliability prognosis. The purpose this study was therefore, identify novel histopathological prognostic markers through exhaustive computational image analysis 80 size shape subsets epithelial clusters in tumors. group 102 had a follow-up...
Tumor histomorphology is crucial for the prognostication of breast cancer outcomes because it contains histological, cellular, and molecular tumor heterogeneity related to metastatic potential. To enhance prognosis, we aimed apply radiomics analysis-traditionally used in 3D scans-to 2D histopathology slides. This study tested analysis a cohort 92 specimens outcome addressing -omics dimensionality by comparing models with moderate high feature counts, using least absolute shrinkage selection...
Human epidermal growth factor receptor‐2 (HER‐2) is usually determined as a potential target for breast cancer therapy. The purpose of the present study was to compare chromogenic in situ hybridization (CISH) with immunohistochemistry (IHC) determination HER‐2 status, metastatic patients screened clinical chemotherapy ± herceptin. It possible assess both CISH and IHC 56 cases, using Detection Kit (Zymed) HercepTest (DakoCytomation), respectively. amplified by 32 cases (57%) while 33 (59%)...
Summary The purpose of this study was to improve the prognostic value tumour histopathology image analysis methodology by preprocessing. Key qualities were modified including contrast, sharpness and brightness. texture information subsequently extracted from images haematoxylin/eosin‐stained tissue sections GLCM, monofractal multifractal algorithms without any analytical limitation predefined structures. Images derived patient groups with invasive breast carcinoma (BC, 93 patients)...
The aim of this study was to determine the relationship between amplification HER2 (Human epidermal growth factor receptor 2) and Topo2a (topoisomerase 2a) their influence on prognosis in metastatic breast cancer (MBC) patients. Amplification both genes determined by chromogenic situ hybridization (CISH) primary tumor tissue 71 MBC Starting point for follow-up time diagnosis disease. Although there significant correlation alterations, not strictly related amplification. Follow-up patients...
The aim of this study was to determine the relationship between amplification HER2 (Human epidermal growth factor receptor 2) and Topo2a (topoisomerase 2a) their influence on prognosis in metastatic breast cancer (MBC) patients. Amplification both genes determined by chromogenic situ hybridization (CISH) primary tumor tissue 71 MBC Starting point for follow-up time diagnosis disease. Although there significant correlation alterations, not strictly related amplification. Follow-up patients...
In tumors in which estrogen receptor (ER) and growth factor signaling pathways are simultaneously active, there is a bidirectional cross-talk that results positive feedback cycle of cell survival proliferation stimuli. Beside the postulated inverse correlation between ER HER2 (human epidermal 2) as consequence repressive loop, also other mechanisms regarding ER-HER2 interactions. It seems MAPK (mitogen-activated protein kinase) pathway has central role synergistic action normal mammary gland...