A5070462646- Lung Cancer Treatments and Mutations
- Cervical Cancer and HPV Research
- Cancer-related Molecular Pathways
- Ovarian cancer diagnosis and treatment
- Molecular Biology Techniques and Applications
- RNA modifications and cancer
- DNA Repair Mechanisms
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- BRCA gene mutations in cancer
- Folate and B Vitamins Research
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- RNA Research and Splicing
- Effects of Radiation Exposure
- Epigenetics and DNA Methylation
- Kruppel-like factors research
- Cancer-related molecular mechanisms research
- Advanced Radiotherapy Techniques
- MicroRNA in disease regulation
- Nutrition, Genetics, and Disease
- Prostate Cancer Treatment and Research
- Bioactive natural compounds
- Cancer Risks and Factors
- Viral-associated cancers and disorders
Oncology Institute of Vojvodina
2012-2022
Hunan Provincial Agricultural Machinery Authority
2010
Abstract One of the challenges radiation oncology in era personalized medicine is identification biomarkers associated with individual radiosensitivity. The aim research was to evaluate possible clinical value associations between clinical, physical, and biological factors, risk for development acute radiotoxicity patients prostate cancer. study involved forty four treated three-dimensional conformal radiotherapy. concentrations IL-1β, IL-2, IL-6, IFN-γ TGF-β1 were assessed before...
Transforming growth factor beta (TGF-β) plays a complex role in carcinogenesis. In 30 melanoma patients and 20 healthy controls (HC) we analysed functional phenotypic characteristics of NK cells by Flow cytometry, gene expression TGF-β1 peripheral blood mononuclear qPCR serum supernatant level free ELISA. Melanoma had significantly higher circulatingTGF-β1 compared to HC, especially those with metastasis into the central nervous system (subclass M1d) high LDH values. HC PBMC. values...
OBJECTIVE: The polymorphic variations of DNA repair genes may contribute to functional deficiencies in processes increasing susceptibility cancer. We aimed investigate the impact 135G>C RAD51 and XRCC1 Arg399Gln polymorphisms
Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme regulating the intracellular folate metabolism which plays an important role in carcinogenesis through DNA methylation and nucleotide synthesis. The common MTHFR single polymorphism C677T has been reported to be associated with reduced enzymatic activity. In order investigate influence of this on risk chronic myeloid leukemia (CML), we performed case-control study Serbian population 52 patients CML 53 healthy control subjects....
Thanks to immense improvements in technology over the past few decades, we have witnessed a major shift towards idea that breast cancer results from combined effect of multiple common alleles conferring low risk. This study investigates role 3 nonsynonymous SNPs DNA repair genes XRCC1 (R399Q), RAD51 (G135C) and TP53 (Arg72Pro) Serbian women.Cases BRCA1/2-negative hereditary (n = 52), sporadic 106) age-matched cancer-free female controls 104) were obtained Institute for Oncology Radiology...
The genetic background of each person might affect the severity radiotherapy (RT)-induced normal tissue toxicity. aim study was to evaluate influence TGFB1 C-509T and Leu10Pro, XRCC1 Arg280His XRCC3 Thr241Met polymorphisms as well level radiation-induced CD8 T-lymphocyte apoptosis (RILA) on adverse effects RT for prostate cancer (PCa). included 88 patients with localized or locally advanced PCa who were treated RT. determined by PCR-RFLP analysis DNA from peripheral blood mononuclear cells....
Aberrant expression of different tight junction proteins, including the junctional adhesion molecule-A (JAM-A), has been frequently reported in association with tumor progression several malignancies. To our knowledge, this is first study examining clinical significance JAM-A gene epithelial ovarian cancer.JAM-A levels 44 cancer and 12 benign formalin-fixed paraffin-embedded samples were determined by reverse transcription quantitative polymerase chain reaction. Receiver operating...
The widespread use of gene expression analyses has been limited by the lack a critical evaluation methods used to extract nucleic acids from human tissues. For evaluating patterns in whole blood or leukocytes, method RNA isolation needs be considered as variable design experiment. Quantitative real-time PCR (qPCR) is widely for quantification today?s clinical practice. Blood samples preferred source qPCR should carefully handled and prepared not inhibit analyses. present study was designed...