A5002535871- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- IL-33, ST2, and ILC Pathways
- Histone Deacetylase Inhibitors Research
- Chemokine receptors and signaling
- Contact Dermatitis and Allergies
- Immune cells in cancer
- Computational Drug Discovery Methods
- Peptidase Inhibition and Analysis
- Animal testing and alternatives
- Cancer Mechanisms and Therapy
- Cytokine Signaling Pathways and Interactions
- Dermatology and Skin Diseases
- Meat and Animal Product Quality
- Protein Degradation and Inhibitors
- COVID-19 Impact on Reproduction
- Effects of Radiation Exposure
- Advanced Breast Cancer Therapies
- Epigenetics and DNA Methylation
- Global Trade and Competitiveness
Oncology Institute of Vojvodina
2016-2025
GTx (United States)
2014
University of Belgrade
2013
University of Kragujevac
2013
Opća Bolnica Zadar
2009-2010
As innate immune cells natural killer (NK), NK-like T and CTLγδ are important in antitumour response multiple myeloma (MM), the aim of this study was to investigate some functional phenotypical characteristics these MM.
Abstract One of the challenges radiation oncology in era personalized medicine is identification biomarkers associated with individual radiosensitivity. The aim research was to evaluate possible clinical value associations between clinical, physical, and biological factors, risk for development acute radiotoxicity patients prostate cancer. study involved forty four treated three-dimensional conformal radiotherapy. concentrations IL-1β, IL-2, IL-6, IFN-γ TGF-β1 were assessed before...
With the aim of simultaneously modulating epigenetic system and protein kinase pathway, we selected enzyme histone deacetylase (HDAC) Rho-associated kinases (ROCK) as desired targets to develop potential multitarget anticancer agents with additional antimetastatic properties. We report here rational design, synthesis, biological evaluation first-in-class HDAC/ROCK inhibitors in pancreatic ductal adenocarcinoma (PDAC) triple-negative breast cancer (TNBC). A molecular docking study performed...
Aims Despite efficacy of anti-PD-1 blockade in treatment metastatic melanoma (MM), many patients achieve rapid disease progression (DP). Therefore, the aim this study is to better define biomarkers for DP by analysing levels circulating cytokines TGF-β, IFN-γ, IL-6, IL-8 and IL-10 MM prior therapy. Methods Cytokine were evaluated before therapy with pembrolizumab peripheral blood BRAF wild-type (wt) ELISA method. Results In study, we give pretherapy BRAFwt analyse them according metastasis...
In metastatic melanoma (MM) immunomodulating agents, such as interleukin-2 (IL-2) and interferon-α (IFN-α), have shown therapeutic benefit they enhance antitumor immune response. Considering tumor-induced suppression of natural killer (NK) cell activity, it is interest to study the affect these cytokines on functional receptor characteristics CD16-defined NK cells their dim bright subsets. Peripheral blood lymphocytes MM patients in clinical stage IV were treated vitro for 18 h with IFN-α...
Transforming growth factor beta (TGF-β) plays a complex role in carcinogenesis. In 30 melanoma patients and 20 healthy controls (HC) we analysed functional phenotypic characteristics of NK cells by Flow cytometry, gene expression TGF-β1 peripheral blood mononuclear qPCR serum supernatant level free ELISA. Melanoma had significantly higher circulatingTGF-β1 compared to HC, especially those with metastasis into the central nervous system (subclass M1d) high LDH values. HC PBMC. values...
Regional lymph nodes (LNs) represent the first barrier in lymphogenic tumor dissemination melanoma. Natural killer (NK) cells, effector cell subpopulation of innate immune system, are line antitumor defense. Therefore, aim this study was to investigate effect interleukin (IL)-2 and IL-15, two cytokines with similar immune-enhancing effects, on cytotoxic function immunophenotype NK cells from regional LNs melanoma patients. Mononuclear purified 50 patients clinical stage II-IV were treated...
Numerous immunosuppressive cells such as myeloid-derived suppressor (MDSCs) and inhibitory cytokines identified in melanoma microenvironment have the important role immune escape. Therefore, this study we analyzed monocytic (m)MDSCs peripheral blood of metastatic (MM) patients. In 35 MM patients 30 healthy controls percentage CD14 + HLA-DR- mMDSCs monocyte gate mean fluorescence intensity Foxp3 CD25 CD4 regulatory T by Flow cytometry. Serum levels transforming growth factor beta,...
NK cells are important effectors of innate immunity that mount the first line defense toward tumor growth. Interleukin-4 (IL-4) has recently been shown to regulate cell function, although its role in regulation function cancer patients not clarified. The aim this study was investigate effect IL-4 on and receptor characteristics CD16-defined their cytotoxic CD16bright regulatory CD16dim subsets. Peripheral blood lymphocytes obtained from 36 metastatic melanoma (MM) treated for 18 h with 10...
Alterations in the actin cytoskeleton correlates to tumor progression and affect critical cellular processes such as adhesion, migration invasion. Rho-associated coiled-coil-containing protein kinases (ROCK1 ROCK2), important regulators of cytoskeleton, are frequently overexpressed various malignancies. The aim this study was therefore identify key structural features ROCK1/ROCK2 inhibitors using computer-aided drug design (CADD) approaches. In addition, new developed ROCK provided a...