The aim of this study was to investigate the cardioprotective activity vitamin E against doxorubicin alone and in combination with cyclophosphamide mice. Female BalbC/NIH mice were treated (100 IU/kg, orally) 24 hr before single bolus doses (10 mg/kg, intravenously), or (150 intraperitoneally). Non-treated animals served as negative controls, while positive control groups received cyclophosphamide. For evaluation, serum enzyme aspartate aminotransferase (AST), lactate dehidrogenase (LDH),...

Doxorubicin is one of the most active drugs in oncology, with cardiotoxicity as a serious side effect its application. The aim this study was to investigate dexrazoxane and amifostine impact on evolution myocardial changes induced by doxorubicin. BalbC female mice were treated doxorubicin only (10 mg/kg, single intravenous push), or (200 intraperitoneal [ip]) ip) 60 mins 30 prior treatment doxorubicin, respectively. Blood sampling for determination conventional serum-marker activity...

8-Chloro-cyclic-adenosine-3',5'-monophosphate (8-Cl-cAMP), a site-selective synthetic cyclic adenosine 3',5'-monophosphate (cAMP) analog exhibits growth inhibition in broad spectrum of human cancer lines. However, detailed studies on the effects exerted by cAMP analogs cell-cycle kinetics have been lacking. We examined and compared effect 8-Cl-cAMP two glioma cell lines, U87MG (p53wt) U251MG (p53mt). A flow cytometric analysis distribution as well apoptosis evaluation were performed...

Abstract Background The few chemoimmunotherapy trials that together with dacarbazine (DTIC) and interferon‐α 2a (IFNα), include retinoic acid (RA), did not detailed immunological evaluation of functional phenotypic natural killer (NK) cell characteristics, have shown contradictory clinical results. Materials methods Malignant melanoma (MM) patients undergoing phase II‐randomized were treated DTIC, IFNα (Hoffmann‐La Roche) (group A, n = 31), 13‐ cis‐ RA (Isotretinoin, Hoffmann‐La Roche,...

<title>Abstract</title> <bold>Purpose:</bold> To investigate the long-term prognosis of appendiceal tumours incidentally detected at appendicectomy for suspicion benign appendicitis. <bold>Methods:</bold> A retrospective register-based single centre cohort study was carried out, using data from local acute quality register cases operated on Department Surgery, South General Hospital, Stockholm, Sweden. The colorectal cancer also used to identify appendix tumours. period between January 2004...

Abstract Purpose To investigate the long-term prognosis of appendiceal tumours incidentally detected at appendicectomy for suspicion benign appendicitis. Methods A retrospective register-based single centre cohort study was carried out, using data from local acute quality register cases operated on Department Surgery, South General Hospital, Stockholm, Sweden. The colorectal cancer also used to identify appendix tumours. period between January 2004 and 2023. Survival calculated according...

Purpose and methods A large body of experimental evidence has confirmed that different tumors, including breast carcinomas, can stimulate specific T-cell-mediated immune responses. In this study we have analyzed patterns T-cell clonality in tumor samples 54 cancer patients classified as lymph node negative, N 0 (n=16), or positive, + (n=38). The T-cells was by the PCR-PAGE method. Results Monoclonal/oligoclonal (M/O) populations were found 15 patients, nine six . all groups (N , ) incidence...

BACKGROUND: Eosinophilic esophagitis (EoE) is an immune-mediated antigen-triggered inflammatory disease of the esophagus. Our aim was to investigate responses by a new ex vivo biopsy provocation-based method, stimulating biopsies with food extracts, possible antigens. METHODS: An experimental study conducted on esophageal from children who underwent esophagogastroduodenoscopy. Supernatants were collected before and after stimulation extracts analyzed for markers, as also blood saliva. The...

BACKGROUND: Eosinophilic esophagitis (EoE) is an immune-mediated antigen-triggered inflammatory disease of the esophagus. Our aim was to investigate responses by a n

Abstract Objectives Eosinophilic esophagitis (EoE) is an immune‐mediated antigen‐triggered inflammatory disease of the esophagus. Our aim was to investigate responses by ex vivo biopsy provocation‐based method, stimulating biopsies with milk, wheat, and egg extracts. Methods An experimental study conducted on esophageal from children who underwent esophagogastroduodenoscopy. Supernatants were collected before after stimulation food extracts analyzed for 45 different markers. Biopsies also...

19000 Background: The activity of NK cells, expression CD69, and serum LDH were evaluated in terms response to therapy metastatic melanoma patients. Methods: In phase II clinical study (MM) patients treated with DTIC (800 mg/m 2 , d1) IFN-alpha 2a (5×10 6 IU/m s.c., d2–6 (group A, n=25) 28 received the same supplemented RA, 60 mg/d, d1–10 B). Before after each cycle cell activity, CD69+NKcells monitored 39 healthy controls. Results: There is no significant difference OR A 32%, B 21%), time...

Konjevic, G.1 2; Jovic, V.1; Radovanovic, A.1; Radulovic, S.1; Jelic, Spuzic, I.1 2 Author Information

12514 Background: As melanoma (MM) is an immunogenic tumor with poor response to chemotherapy immunomodulating agents are applied in order potentiate cytotoxic effect of and enhance antitumor immune response. Beside therapeutic benefit IFN-α IL-2, 13-cis retinoic acid (RA), as antiproliferative, differentiating agent also investigated. The these on NK cells, main innate system effectors, being Methods: 35 patients MM stage IV prior therapy 20 controls were We evaluated activity the...