A5029114835- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Head and Neck Cancer Studies
- Immune Response and Inflammation
- RNA modifications and cancer
- Vitamin D Research Studies
- Cancer-related gene regulation
- Histone Deacetylase Inhibitors Research
- Cancer Immunotherapy and Biomarkers
- Folate and B Vitamins Research
- Oral Health Pathology and Treatment
- Circular RNAs in diseases
- Osteoarthritis Treatment and Mechanisms
- Genomics, phytochemicals, and oxidative stress
- Protein Degradation and Inhibitors
- Inflammatory mediators and NSAID effects
- Extracellular vesicles in disease
- Cancer-related Molecular Pathways
- Thyroid Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Wound Healing and Treatments
- Nutrition, Genetics, and Disease
- Pain Mechanisms and Treatments
- Vitamin K Research Studies
Military Medical Academy
2016-2025
University of Defence
2013-2024
University of Belgrade
2024
Military Medical Academy
2021
Centre of Research Excellence in Nutrition and Metabolism
2021
Faculty (United Kingdom)
2019
Laboratory of Molecular Genetics
2014
Karolinska Institutet
2013
Adult mesenchymal stem cells (MSCs) have recently become a potent tool in regenerative medicine. Due to certain shortcomings of obtaining bone marrow MSCs, alternate sources MSCs been sought. In this work, we studied from dental pulp (DP-MSCs) and follicle (DF-MSCs), isolated the same tooth/donor, define differences their phenotypic properties, differentiation potential, immunomodulatory activities. Both cell types showed colony-forming ability expressed typical markers, but differed levels...
Periodontitis, a prevalent inflammatory condition, affects the supporting structures of teeth, leading to significant oral health challenges. Traditional treatments have primarily focused on mechanical debridement, antimicrobial therapy, and surgery, which often fail restore lost periodontal structures. Emerging as novel approach in regenerative medicine, extracellular vesicle (EV) including exosomes, leverages nano-sized vesicles known for facilitating intercellular communication modulating...
J Oral Pathol Med (2012) 41 : 779–787 Background: Genetic polymorphisms of vitamin D receptor gene (VDR) and genes involved in metabolism pathway, CYP27B1 CYP24B1, may affect individual susceptibility to oral squamous cell carcinoma. The purpose this study was evaluate the associations between VDR, CYP24A1 with cancer risk survival. Methods: Study cohort consisted 110 patients 122 healthy controls. genotypes analysed were determined by PCR–RFLP or real‐time PCR method. Results: significant...
The aim of this study is to investigate association between polymorphisms in TLR2, TLR3, TLR4 and CD14 genes or their haplotypes with oral squamous cell carcinomas (OSCC) risk survival.The was conducted on 93 OSCC patients 104 cancer-free controls. Polymorphisms were genotyped by real-time PCR PCR-RFLP method.Significant increase cancer observed individuals mutated genotype TLR3 rs3775291 polymorphism (OR = 1.096, P 0.036) compared wild-type. heterozygous rs5743312 had worse survival group...
Background: Small papillary thyroid carcinomas with the largest dimension of 10 mm are slow-growing and self-limiting tumors, most which have no potential for progression, rarely becoming clinically evident or undergoing regressive changes. Their anaplastic transformation, primarily in gland into lymph node metastasis, is extremely rare. Case Presentation: A 66-year-old female patient was admitted to our hospital diagnostics treatment a large tumor on left neck side. Preoperative imaging...
Several studies have reported Oral Squamous Cell Carcinoma ( OSCC) association with etiological factors, such as smoking and alcohol. The aim of the present study was to establish whether methylenetetrahydrofolate reductase MTHFR) C677T genotype a high alcohol intake, solely or in interaction, an impact on oral cancer risk, DNA methylation, multiple methylation tumor-related genes. MTHFR genetic polymorphism determined by PCR/RFLP method, assessed nested methylation-specific PCR. risk for...
Abstract MicroRNAs (miRNAs) are known to regulate most biological processes and have been found dysregulated in a variety of diseases, including multiple sclerosis (MS). In this study, we characterized miRNAs that associate with susceptibility develop experimental autoimmune encephalomyelitis (EAE) rats, well-established animal model MS. Using Illumina next-generation sequencing, detected 544 the lymph nodes EAE-susceptible Dark Agouti EAE-resistant Piebald Virol Glaxo rats during immune...
Polymorphisms in long non-coding RNA and microRNA genes may play a significant role the susceptibility progression of papillary thyroid carcinoma (PTC). The current study investigates polymorphisms HOTAIR rs920778, MIR155HG rs1893650, TERC rs10936599, miR-155 rs767649, miR-196a2 rs11614913 miR-146a rs2910164 102 PTC patients 106 age- sex-matched controls Caucasian Serbian population, using real-time PCR. We observed differences genotype distributions rs920778 (p = 0.016) rs1893650 0.0002)...
Previous studies have reported that vitamin D receptor (VDR) gene polymorphisms are associated with the occurrence of various cancers, including melanoma. The aim current study was to investigate association VDR melanoma risk, clinicopathological characteristics, and levels. group included 117 patients (84 superficial spreading 33 nodular melanoma). control 122 sex-matched age-matched healthy-blood donors same ethnicity. FokI, EcoRV, TaqI, ApaI were genotyped by real-time PCR. In 60...
The inter-individual variability in CYP2C19-mediated metabolism may affect the antidepressant treatment. aim of this study is to evaluate differences efficacy and tolerability between different CYP2C19 metabolizer categories inpatients suffering from major depressive disorder. cohort was divided into experimental groups based on genotype it contained 24 slow (SMs), 41 normal (NMs), 37 fast metabolizers (FMs). Efficacy were assessed at baseline, after two four weeks as a follow-up. primary...
To evaluate the association between catechol-O-methyltransferase (COMT) gene polymorphisms and temporomandibular disorders (TMD), TMD pain, psychosocial impairment related to TMD, postoperative pain.A total of 90 patients with a diagnosis painful 92 matched controls were investigated for presence variables by Research Diagnostic Criteria TMD. In prospective cohort study 40 subjects who underwent extraction at least one fully impacted mandibular third molar, had 6 months post-surgery...
Recent studies indicate various molecular abnormalities in oral squamous cell carcinomas (OSCC), including DNA methylation of tumor-associated genes. Although promoter hypermethylation Wnt pathway antagonists RUNX3 (Runt-related transcription factor 3) and inhibitory 1 (WIF1) has been identified as a common event number carcinomas, status the role possible tumor suppressor head neck cancer are yet controversial. The aim our study is to determine occurrence WIF1 genes correlation with...