J Oral Pathol Med (2012) 41 : 779–787 Background: Genetic polymorphisms of vitamin D receptor gene (VDR) and genes involved in metabolism pathway, CYP27B1 CYP24B1, may affect individual susceptibility to oral squamous cell carcinoma. The purpose this study was evaluate the associations between VDR, CYP24A1 with cancer risk survival. Methods: Study cohort consisted 110 patients 122 healthy controls. genotypes analysed were determined by PCR–RFLP or real‐time PCR method. Results: significant...

The aim of this study is to investigate association between polymorphisms in TLR2, TLR3, TLR4 and CD14 genes or their haplotypes with oral squamous cell carcinomas (OSCC) risk survival.The was conducted on 93 OSCC patients 104 cancer-free controls. Polymorphisms were genotyped by real-time PCR PCR-RFLP method.Significant increase cancer observed individuals mutated genotype TLR3 rs3775291 polymorphism (OR = 1.096, P 0.036) compared wild-type. heterozygous rs5743312 had worse survival group...

Several studies have reported Oral Squamous Cell Carcinoma ( OSCC) association with etiological factors, such as smoking and alcohol. The aim of the present study was to establish whether methylenetetrahydrofolate reductase MTHFR) C677T genotype a high alcohol intake, solely or in interaction, an impact on oral cancer risk, DNA methylation, multiple methylation tumor-related genes. MTHFR genetic polymorphism determined by PCR/RFLP method, assessed nested methylation-specific PCR. risk for...

To investigate whether polymorphisms of cluster differentiation 14 (CD14), tumor necrosis factor alpha (TNFα), interleukin (IL)6, IL10, and IL1ra genes are associated with the risk peri-implantitis susceptibility in patients dental implants Serbian population.Isolated DNA from blood was used for IL10-1082, TNFα-308, IL6-174, CD14-159, 1 receptor antagonist (IL1ra) genotyping using polymerase chain reaction (PCR)-based methodology. Clinical parameters included: peri-implant pocket depth...

Previous studies have reported that vitamin D receptor (VDR) gene polymorphisms are associated with the occurrence of various cancers, including melanoma. The aim current study was to investigate association VDR melanoma risk, clinicopathological characteristics, and levels. group included 117 patients (84 superficial spreading 33 nodular melanoma). control 122 sex-matched age-matched healthy-blood donors same ethnicity. FokI, EcoRV, TaqI, ApaI were genotyped by real-time PCR. In 60...

To evaluate the association between catechol-O-methyltransferase (COMT) gene polymorphisms and temporomandibular disorders (TMD), TMD pain, psychosocial impairment related to TMD, postoperative pain.A total of 90 patients with a diagnosis painful 92 matched controls were investigated for presence variables by Research Diagnostic Criteria TMD. In prospective cohort study 40 subjects who underwent extraction at least one fully impacted mandibular third molar, had 6 months post-surgery...

Total-body irradiation of rats with doses ranging from an LD10/30 to LD100/30 induced a dose-dependent increase in the concentration serum protein associated acute response irradiation. However, this was reached at later time and not as pronounced described previously during typical phase found experimentally (A. Koj, Structure Function Plasma Proteins, Vol. 1, pp. 73-131, Plenum Press, London, 1974). The greatest concentrations acute-phase proteins third seventh days postirradiation. At...

Recent studies indicate various molecular abnormalities in oral squamous cell carcinomas (OSCC), including DNA methylation of tumor-associated genes. Although promoter hypermethylation Wnt pathway antagonists RUNX3 (Runt-related transcription factor 3) and inhibitory 1 (WIF1) has been identified as a common event number carcinomas, status the role possible tumor suppressor head neck cancer are yet controversial. The aim our study is to determine occurrence WIF1 genes correlation with...

This study examined the single nucleotide polymorphisms (SNPs) in high-mobility group box 1 (HMGB1) gene patients with oral squamous cell carcinoma (OSCC) and lichen planus (OLP).The was conducted on 93 OSCC, 53 OLP, 100 controls, all Caucasians of same ethnicity, matched by age. HMGB1 genotypes for 4 SNPs, 2262G/A (rs1045411), 1177G/C (rs3742305), 3814C/G (rs2249825), rs4540927, were assessed using TaqMan SNP Genotyping Assays, Applied Biosystems.The 1177GG genotype associated lymph-node...

Several studies have suggested that the metabolism of alcohol is modulated by polymorphisms in genes encoding ethanol-metabolizing enzymes, including dehydrogenase 1C, ADH1C, and cytochrome P450-dependent monooxygenase, CYP2E1. Genetic enzymes may affect individual susceptibility to oral cancer. The purpose this study was investigate associations between ADH1C CYP2E1 gene with squamous cell carcinoma an ethnically homogeneous Caucasian population.Case-control study.Serbian national general...

Recurrent fetal loss (RFL) is a significant clinical problem, occurring in 1% to 5% of reproductive females. Inherited or acquired thrombophilia has been diagnosed 50% 65% women with history unexplained loss. The objective our study was determine the prevalence RFL Serbian population and find out whether presence associated pregnancy losses that occur later than 12th gestational week. We have examined 147 intrauterine death 128 healthy at least 1 uncomplicated pregnancy. antithrombin (AT),...

The aim of this study was to assess whether polymorphisms in toll-like receptor (TLR) and cluster differentiation 14 (CD14) genes are associated with oral lichen planus (OLP) risk clinical course the disease. group consisted 101 patients confirmed OLP 104 healthy blood donors without systemic or mucosal diseases. Single nucleotide TLR2 (rs3804099), TLR3 (rs3775291 rs5743312), TLR4 (rs4986790 rs4986791), CD14 (rs2569190) were genotyped using real-time PCR PCR-restriction fragment length...