Background: In the last decade, regenerative therapies have become one of leading disease modifying options for treatment knee osteoarthritis (OA). Still, there is a lack trials with direct comparison different biological treatments. Our aim was to directly compare clinical outcomes injections Bone Marrow Aspirate Concentrate (BMAC), Platelet-rich Plasma (PRP), or Hyaluronic acid (HA) in OA treatment. Methods: Patients pain and KL grade II IV were randomized receive BMAC, PRP, HA injection...

Periodontitis, a prevalent inflammatory condition, affects the supporting structures of teeth, leading to significant oral health challenges. Traditional treatments have primarily focused on mechanical debridement, antimicrobial therapy, and surgery, which often fail restore lost periodontal structures. Emerging as novel approach in regenerative medicine, extracellular vesicle (EV) including exosomes, leverages nano-sized vesicles known for facilitating intercellular communication modulating...

Multiple System Atrophy (MSA) is a rare, rapidly progressive neurodegenerative disorder marked by autonomic dysfunction, parkinsonism, and cerebellar ataxia. While predominantly affecting individuals in their fifth or sixth decade, advancements assisted reproductive technologies (ART) have created new clinical scenarios involving pregnancies women within MSA’s typical onset range. Given the scarcity of documented MSA pregnancies, this review leverages insights from related Parkinson’s...

Abstract To evaluate the immunomodulating activity of methionine‐enkephalin (Met‐Enk) and leucine‐enkephalin (Leu‐Enk) in development experimental allergic encephalomyelitis (EAE), two strains rats, one highly susceptible to EAE (Lewis rats) other relatively resistant disease (Wistar were used. The animals given daily injections either a high dose (5 mg/kg b.w.) or low (0.2 these opioid peptides, after receiving guinea pig spinal cord combination with immunological adjuvants. A major...

Scaphoid fractures are rare in childhood. Diagnosis is very difficult to establish because carpal bones not fully ossified. In suspected cases comparative or delayed radiography used, as well computerized tomography, magnetic resonance imaging, ultrasound and bone scintigraphy. Majority of scaphoid treated conservatively with good results. case fracture healing various types treatment available.To determine the mechanism injury, clinical process, outcome children.We retrospectively analyzed...

Osteoarthritis (OA) is a progressive inflammatory disease of synovial joints and leading cause disability among adults. Inflammation-related genes, including genes for Toll-like receptors (TLRs), are tightly controlled by several microRNAs that, in addition to their pivotal role the epigenetic regulation target ligands TLR activation downstream signaling. Thus, we evaluated association between OA risk genetic variants TLR2, TLR3, TLR4, TLR7, TLR9, that regulate TLRs signaling miR146a,...

Aim: To assess the efficacy of a bioregenerative scaffold derived from bone marrow aspirate, cancellous autograft, platelet-rich plasma and autologous fibrin in treating supracondylar femur nonunions. Methods & materials: Three patients with nonunions following multiple surgical failures underwent stabilization application novel scaffold. x-rays subjective scales were collected before surgery at 6, 12 24 months post-surgery. Results: All exhibited healing sufficient callus formation, as...

Musculoskeletal problems are common in instrumental musicians. Little is known about the factors that place musicians at risk, and ways which can prevent these problems. Overuse syndrome most reported diagnosis among suffering from playing related musculoskeletal injuries. The study group comprised 50 employed Symphony Orchestra of Serbian National Theatre Novi Sad. Out musicians, 30 (60 %) male 20 (40 female. Higher frequencies presence symptoms were neck, region trapezius, back, shoulder,...

Aim: To explore the effect that location of needle placement has on efficacy and tolerability bone marrow aspirate concentrate injections during treatment knee osteoarthritis. Methods: Bone were administered to 111 patients via superolateral, anteromedial or anterolateral portals. Pain was assessed by visual analog scale before 3, 7, 14 21 days after intervention. Knee function Western Ontario McMaster Universities Osteoarthritis Index, Injury Outcome Score International Documentation...

Adrenal rests are usually unrecognized during operation, and the incidence of ectopic adrenal cortical tissue in pediatric patients inguinal surgery procedures is unknown. We performed 3028 groin surgical explorations 2680 aged 1 month to 17 years. Ectopic was found 69 operations (2.2%): 37 1.524 orchiopexy (2.4%), 23 1.115 herniectomy (2.0%), 9 389 hydrocoela operation (2.3%). Statistically there were no significant differences among those three groups. No detected females. Although a few...

Osteoid osteoma is a small benign bone lesion. It generally affects children and young adults. Traditional treatment of osteoid includes excision either by wide resection, or the removal nidus using curettes burrs after opening overlying cortex. Newly developed techniques involve percutaneous ablation tumor computed tomography-guided core-drill destruction thermocoagulation. Fluoroscopic guided extirpation drilling resection procedures have been performed at Institute for Health Care...

It is well known that physical activity has an anabolic effect on bone tissue. But there a lack of information about the intensive in childhood, particularly at prepubertal stage. To examine influence training body composition and mineral density we have studied group soccer players as inactive boys starting phase their peak mass acquisition.A total 62 healthy took part this study. They were divided into two groups. The first one consisted 32 (aged 10.7 +/- 0.5 years), who had been playing...

Background/Aim. Femur fractures in children most often occur as a consequence of traffic accidents, during play and sport activities, due to different pathological states. Diagnosis is rather simple it includes physical radiographycal examination. treatment can be operative unoperative, depending on several facts: age, localisation type fracture, joint injuries soft tissues, the presence other (in polytrauma), economical social aspects, ect. The aim this study was present epidemiological...

Introduction. Anterior tibial muscle hernia is the most frequent lower extremities hernia. The aim of this paper was to present a possibility new surgical technique for anterior reparation. Case report. We presented three cases in adolescents. were diagnosed clinically and ultrasonographycally. In all reconstruction done with periosteal patch plasty fascial defect. Conclusions. Easy approachable, cheap, autologous material, periost, frame plasty, could be one possible solutions treatment.

Autism spectrum disorder (ASD) has recently been linked to neuroinflammation and an aberrant immune response within the central nervous system. The intricate relationship between ASD remains elusive, with a gap in understanding connection specific mechanisms neural manifestations autism. In this study, we employed comprehensive statistical approach, fusing both overarching granular methods examine concentration of 16 cytokines cerebrospinal fluid (CSF) across each autologous bone marrow...

Forearm fractures make 13-18% of all injuries the upper extremities in children. Most them are older than 6 years. The degree tolerance is different but children younger 8 years can tolerate 15-20 degrees angulation, 45 inadequate rotation and total displacement. Older angulation 10 degrees, 30 complete dislocation.Over a period five (1995-2000) 54 with forearm (22 stable 32 unstable fractures) were treated at Pediatric Surgery Clinic Novi Sad. Closed reduction percutaneous pinning...

Abstract Introduction People infected with human immunodeficiency virus (HIV) are more susceptible to endothelial dysfunction due the itself, side effects of antiretroviral therapy and classical risk factors. Endothelial damage is most prominent at locations where laminar blood flow disturbed oscillatory shear stress retrograde dominating. Purpose The goal this study was assess function in people HIV, determine whether their endothelium a short-term increase comparison healthy individuals....