A5048086477- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Cancer Genomics and Diagnostics
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- CAR-T cell therapy research
- SARS-CoV-2 and COVID-19 Research
- Neutropenia and Cancer Infections
- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- COVID-19 Clinical Research Studies
- Ferroptosis and cancer prognosis
- Hormonal and reproductive studies
- Cancer Cells and Metastasis
- Lung Cancer Research Studies
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related molecular mechanisms research
- Neuroblastoma Research and Treatments
- Vaccine Coverage and Hesitancy
- Glioma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Single-cell and spatial transcriptomics
- Epigenetics and DNA Methylation
- Infectious Aortic and Vascular Conditions
University College London
2009-2025
London Cancer
2019-2025
King's College London
2016-2025
Guy's Hospital
2013-2025
Breast Cancer Now
2018-2024
St Thomas' Hospital
2024
The Francis Crick Institute
2019-2023
Second Xiangya Hospital of Central South University
2016-2023
Central South University
2016-2023
CRUK Lung Cancer Centre of Excellence
2019-2023
Improved understanding and management of COVID-19, a potentially life-threatening disease, could greatly reduce the threat posed by its etiologic agent, SARS-CoV-2. Toward this end, we have identified core peripheral blood immune signature across 63 hospital-treated patients with COVID-19 who were otherwise highly heterogeneous. The includes discrete changes in B myelomonocytic cell composition, profoundly altered T phenotypes, selective cytokine/chemokine upregulation SARS-CoV-2-specific...
Both positive and negative regulatory roles have been suggested for the B7 family member PD-L1(B7-H1). PD-L1 is expressed on antigen-presenting cells (APCs), activated T cells, a variety of tissues, but functional significance each cell type not yet clear. To dissect functions in vivo , we generated PD-L1-deficient (PD-L1 –/– ) mice. CD4 + CD8 responses were markedly enhanced mice compared with wild-type vitro . dendritic stimulated greater than produced more cytokines demonstrating an...
The efficacy and safety profiles of vaccines against SARS-CoV-2 in patients with cancer is unknown. We aimed to assess the immunogenicity BNT162b2 (Pfizer-BioNTech) vaccine cancer.
Interaction of the SARS-CoV-2 Spike receptor binding domain (RBD) with ACE2 on host cells is essential for viral entry. RBD dominant target neutralizing antibodies, and several epitopes have been molecularly characterized. Analysis circulating variants has revealed mutations arising in RBD, N-terminal (NTD) S2 subunits Spike. To understand how these affect antigenicity, we isolated characterized >100 monoclonal antibodies targeting NTD, from SARS-CoV-2-infected individuals. Approximately 45%...
Abstract Murine tissues harbor signature γδ T cell compartments with profound yet differential impacts on carcinogenesis. Conversely, human tissue-resident cells are less well defined. In the present study, we show that lung a resident Vδ1 population. Moreover, demonstrate memory and effector phenotypes were enriched in tumors compared nontumor tissues. Intratumoral possessed stem-like features skewed toward cytolysis helper type 1 function, akin to intratumoral natural killer CD8 +...
Abstract Checkpoint inhibition (CPI), particularly that targeting the inhibitory coreceptor programmed cell death protein 1 (PD-1), has transformed oncology. Although CPI can derepress cancer (neo)antigen-specific αβ T cells ordinarily show PD-1-dependent exhaustion, it also be efficacious against cancers evading recognition. In such settings, γδ have been implicated, but functional relevance of PD-1 expression by these is unclear. Here we demonstrate intratumoral TRDV1 transcripts (encoding...
Abstract Recognition and elimination of pathogens cancer cells depend on the adaptive immune system. Thus, accurate quantification subsets is vital for precision medicine. We present lymphocyte estimation from nucleotide sequencing (ImmuneLENS), which estimates T cell B fractions, class switching clonotype diversity whole-genome data at depths as low 5× coverage. By applying ImmuneLENS to 100,000 Genomes Project, we identify genes enriched with somatic mutations in cell-rich tumors,...
Professional phagocytosis in mammals is considered to be performed exclusively by myeloid cell types. In this study, we demonstrate, for the first time, that a mammalian lymphocyte subset can operate as professional phagocyte. By using confocal microscopy, transmission electron and functional Ag presentation assays, find freshly isolated human peripheral blood gammadelta T cells phagocytose Escherichia coli 1 microm synthetic beads via Ab opsonization CD16 (FcgammaRIII), leading processing...
An innate-like γδ T cell compartment in healthy human breast is described and shown to correlate with remission triple-negative cancer.
Abstract Activated human blood γδ T cells have also been previously demonstrated to behave as professional APCs, although the processes that control APC function not characterized. n this study, we show acquisition of potent by is achieved after physical interaction with an Ab-coated target cell, a process refer licensing. In cancer models, licensing tumor-reactive mAbs promotes uptake tumor Ags and presentation αβ cells. We propose Ab mechanism whereby adaptive properties are induced their...
ABSTRACT Background The efficacy and safety profile of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have not been definitively established in immunocompromised patient populations. Patients with a known cancer diagnosis were hitherto excluded from trials the currently clinical use. Methods This study presents data on immune BNT162b2 (Pfizer-BioNTech) vaccine 54 healthy controls 151 mostly elderly patients solid haematological malignancies, respectively,...
A Correction to this paper has been published: https://doi.org/10.1038/s41591-020-01186-5
Abstract Person-to-person transmission of SARS-CoV-2 virus has triggered a global emergency because its potential to cause life-threatening Covid-19 disease. By comparison paucisymptomatic clearance by most individuals, been proposed reflect insufficient and/or pathologically exaggerated immune responses. Here we identify consensus peripheral blood signature across 63 hospital-treated patients who were otherwise highly heterogeneous. The core conspicuously blended adaptive B cell responses...
The cohesion and internal friction angle were characterized as quadratic functions of strain assumed to follow the Mohr-Coulomb criterion after yield peak strength.These mechanical parameters their variations in post-peak softening stage can be exactly ascertained through simultaneous solution based on data points stress-strain curves triaxial compression tests.Taking influence fault into account, variation strata pressure roadway convergence with coal advancement, temporal spatial...
Despite its aggressive nature, triple-negative breast cancer (TNBC) often exhibits leucocyte infiltrations that correlate with favorable prognosis. In this study, we offer an explanation for apparent conundrum by defining TNBC cell subsets overexpress the IL15 immune receptor IL15RA. This usually forms a heterotrimer IL2 receptors IL2RB and IL2RG, which regulates proliferation differentiation of cytotoxic T cells NK cells. However, unlike IL15RA, IL2RG are not upregulated in basal-like...
In the adrenal gland, neuroendocrine cells that synthesize catecholamines and epithelial produce steroid hormones are united beneath a common organ capsule to function as single stress-responsive organ. The functional anatomy of hormone–producing cortex catecholamine-producing medulla is ill defined at level small molecules. Here, we report comprehensive high-resolution mass spectrometry imaging (MSI) map normal human gland. A large variety biomolecules was accessible by matrix-assisted...