Marcin Skrzypski
A5052637796- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- Nutrition and Health in Aging
- Genomic variations and chromosomal abnormalities
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- PI3K/AKT/mTOR signaling in cancer
- Palliative Care and End-of-Life Issues
- Cancer Diagnosis and Treatment
- Molecular Biology Techniques and Applications
- Immunotherapy and Immune Responses
- Cancer-related Molecular Pathways
- Cancer, Hypoxia, and Metabolism
- Food Allergy and Anaphylaxis Research
- CAR-T cell therapy research
- Genetic factors in colorectal cancer
- Single-cell and spatial transcriptomics
Gdańsk Medical University
2013-2024
The Francis Crick Institute
2022-2024
Cancer Research UK
2019-2022
London Cancer
2019-2022
CRUK Lung Cancer Centre of Excellence
2019-2022
University College London
2019-2022
University of Gdańsk
2008
Institut Català d'Oncologia
2007
Hospital Universitari Germans Trias i Pujol
2007
Instytut Gruźlicy i Chorób Płuc
2002
Abstract Murine tissues harbor signature γδ T cell compartments with profound yet differential impacts on carcinogenesis. Conversely, human tissue-resident cells are less well defined. In the present study, we show that lung a resident Vδ1 population. Moreover, demonstrate memory and effector phenotypes were enriched in tumors compared nontumor tissues. Intratumoral possessed stem-like features skewed toward cytolysis helper type 1 function, akin to intratumoral natural killer CD8 +...
Abstract The phenomenon of mixed/heterogenous treatment responses to cancer therapies within an individual patient presents a challenging clinical scenario. Furthermore, the molecular basis mixed intra-patient tumor remains unclear. Here, we show that patients with metastatic lung adenocarcinoma harbouring co-mutations EGFR and TP53 , are more likely have tyrosine kinase inhibition (TKI), compared those mutation alone. combined presence whole genome doubling (WGD) leads increased instability...
Background Although early-stage non-small-cell lung cancer (NSCLC) is considered a potentially curable disease following complete resection, patients have wide spectrum of survival according to stage (IB, II, IIIA). Within each stage, gene expression profiles can identify with higher risk recurrence. We hypothesized that altered mRNA in nine genes could help predict outcome: excision repair cross-complementing 1 (ERCC1), myeloid zinc finger (MZF1) and Twist1 (which regulate N-cadherin...
Abstract Purpose: Current staging methods are imprecise for predicting prognosis of early-stage non–small-cell lung cancer (NSCLC). We aimed to develop a gene expression profile stage I and II NSCLC, allowing identification patients with high risk disease recurrence within 2 3 years after initial diagnosis. Experimental Design: used whole-genome microarrays analyze frozen tumor samples from 172 NSCLC (pT1-2, N0-1, M0) five European institutions, who had undergone complete surgical resection....
Chemotherapy is a primary method to treat cancer. While chemotherapeutic drugs are designed target rapidly dividing cancer cells, they can also affect other cell types. In the case of dermal cells and macrophages involved in wound healing, cytotoxicity often leads development chronic wounds. The situation becomes even more severe when chemotherapy combined with surgical tumor excision.
Abstract Purpose: Adjuvant treatment may improve survival in early-stage squamous cell carcinoma (SCC) of the lung; however, absolute gain is modest and mainly limited to stage II-IIIA. Current staging methods are imprecise indications prognosis, but high-risk patients can be identified by gene expression profiling considered for adjuvant therapy. Experimental Design: The 29 genes was assessed reverse transcriptase quantitative PCR frozen primary tumor specimens obtained from 66 SCC who had...
Abstract Purpose: Clinical staging does not adequately risk stratify patients with early stage non–small cell lung cancer. We sought to generate a real-time PCR (RT-PCR)–based prognostic model in adenocarcinoma, the dominant histology of cancer United States. Experimental Design: studied gene expression 61 candidate genes 107 completely surgically resected adenocarcinoma using RT-PCR. used crossvalidation methods select and validate based on limited number genes. A score was generated...
The role of adjuvant chemotherapy in stage T2-T3N0 colon cancer (CC) is controversial and there are currently no reliable factors allowing for individual selection patients with high risk relapse such therapy. We searched microRNA-based signature prognostic significance this group. assessed by qRT-PCR expression 754 microRNAs (miRNAs) tumour samples from 85 pT2-3N0 CC treated surgery alone. MiRNA was compared between two groups patients: 40 45 who did not develop distant metastases after...
About 50% of non-small cell lung cancer (NSCLC) patients develop distant metastases following pulmonary resection. Currently, there are no reliable factors allowing for individual selection high-risk adjuvant systemic therapies. We assessed by quantitative reverse transcription PCR microRNA (miRNA) expression in 273 stage I–IIIA NSCLC samples. Expression 677 miRNAs was evaluated fresh-frozen tumour samples the training cohort 50 squamous carcinoma (SCC) who underwent curative surgery. Of...
Abstract Background PDC*lung01 (IMP) is a therapeutic cancer vaccine based on an irradiated plasmacytoid dendritic cell line loaded with HLA-A*02:01-restricted peptides (NY-ESO-1, MAGE-A3, MAGE-A4, Multi-MAGE-A, MUC1, Survivin and Melan-A), able to prime expand peptide-specific CD8+ T cells in vitro vivo, synergistic anti-PD-1. Methods In this phase I/II study, HLA-A*02 positive NSCLC pts were enrolled 4 cohorts: resected stage II/IIIA adjuvant setting treated low dose (A1) or high (A2) of...
<i>Background:</i> The safety profile of venom immunotherapy is a relevant issue. We evaluated the frequency severe adverse events (SAE), associated risk factors, retrospective comparison pretreatment protocols including solely H<sub>1</sub> receptor blockers and combination H<sub>2</sub> during rush Hymenoptera immunotherapy. <i>Methods:</i> study group comprised 118 patients. treatment was initiated according to 5-day protocol with use...
Mastocytosis is an uncommon disease classified as a myeloproliferative neoplasm, however, its symptoms are broad and place patients at crossroads between dermatology, hematology allergology. Patients with mastocytosis often suffer from resulting the activation release of mediators mast cells, such generalized itching, redness, headache, abdominal cramps, diarrhea, bone pain or arthritis, hypotension shock. The possible severe, fatal near reactions caused by food hypersensitivity reasons for...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Czapiewski P, Bobowicz M, Pęksa R, et al. Keratin 7 expression in lymph node metastases but not the primary tumour correlates with distant and poor prognosis colon carcinoma. Polish Journal of Pathology. 2016;67(3):228-234. doi:10.5114/pjp.2016.63774. APA Czapiewski, P., Bobowicz, M., Pęksa, R., Skrzypski, Gorczyński, A., & Szczepańska-Michalska, K. (2016). Pathology, 67(3), 228-234....