A5034285419- Electron and X-Ray Spectroscopy Techniques
- Advanced Electron Microscopy Techniques and Applications
- Nanoparticles: synthesis and applications
- Ferroelectric and Piezoelectric Materials
- Iron oxide chemistry and applications
- Botany, Ecology, and Taxonomy Studies
- Graphene research and applications
- Nanoparticle-Based Drug Delivery
- Radioactive element chemistry and processing
- Quantum Dots Synthesis And Properties
- Carbon Nanotubes in Composites
- Ecology and Conservation Studies
- Advanced materials and composites
- Plant and animal studies
- Lung Cancer Treatments and Mutations
- Microwave Dielectric Ceramics Synthesis
- Iron Metabolism and Disorders
- Force Microscopy Techniques and Applications
- Nuclear materials and radiation effects
- Integrated Circuits and Semiconductor Failure Analysis
- Bone Tissue Engineering Materials
- Plant Diversity and Evolution
- Ion-surface interactions and analysis
- Horticultural and Viticultural Research
- Botanical Studies and Applications
University of Leeds
2016-2025
AstraZeneca (United States)
2024
AstraZeneca (United Kingdom)
2016-2023
The King's College
1999-2021
Australian National University
2021
Royal Botanic Gardens, Kew
2021
Royal Botanic Garden Sydney
2021
Royal Botanic Gardens Victoria
2021
La Trobe University
2021
East Carolina University
2021
Purpose We report CNS efficacy of osimertinib versus standard epidermal growth factor receptor ( EGFR) tyrosine kinase inhibitors (TKIs) in patients with untreated EGFR-mutated advanced non–small-cell lung cancer from the phase III FLAURA study. Patients and Methods (N = 556) were randomly assigned to or EGFR-TKIs (gefitinib erlotinib); brain scans not mandated unless clinically indicated. asymptomatic stable metastases included. In symptomatic metastases, neurologic status was required be...
Purpose In patients with epidermal growth factor receptor ( EGFR) mutation-positive advanced non-small-cell lung cancer (NSCLC), there is an unmet need for EGFR-tyrosine kinase inhibitors improved CNS penetration and activity against metastases, either at initial diagnosis or time of progression. We report the first comparative evidence osimertinib efficacy versus platinum-pemetrexed from a phase III study (AURA3; ClinicalTrials.gov identifier: NCT02151981) in EGFR T790M-positive NSCLC who...
Inflammation within atherosclerotic lesions contributes to plaque instability and vulnerability rupture. We set out evaluate the use of a macrophage labeling agent identify carotid inflammation by in vivo magnetic resonance imaging (MRI).Thirty patients with symptomatic severe stenosis scheduled for endarterectomy underwent multi-sequence MRI bifurcation before after injection ultrasmall superparamagnetic particles iron oxide (USPIOs). USPIO accumulated macrophages 24 30 plaques (80%). Areas...
In this phase I study (BLOOM), osimertinib, a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), was evaluated in patients with leptomeningeal metastases (LMs) from EGFR-mutated (EGFRm) advanced non-small-cell lung cancer (NSCLC) whose disease had progressed on previous EGFR-TKI therapy.Patients cytologically confirmed LM received osimertinib 160 mg once daily. Objectives were to assess objective response rate (ORR), duration of (DoR), progression-free...
Abstract The phenomenon of mixed/heterogenous treatment responses to cancer therapies within an individual patient presents a challenging clinical scenario. Furthermore, the molecular basis mixed intra-patient tumor remains unclear. Here, we show that patients with metastatic lung adenocarcinoma harbouring co-mutations EGFR and TP53 , are more likely have tyrosine kinase inhibition (TKI), compared those mutation alone. combined presence whole genome doubling (WGD) leads increased instability...
Research Article| July 01, 2009 Plant-driven fungal weathering: Early stages of mineral alteration at the nanometer scale Steeve Bonneville; Bonneville * 1Earth and Biosphere Institute, School Earth Environment, University Leeds, Leeds LS2 9JT, UK *E-mail: s.bonneville@see.leeds.ac.uk. Search for other works by this author on: GSW Google Scholar Mark M. Smits; Smits 2Department Animal Plant Sciences, Sheffield, Western Bank, Sheffield S10 2TN, Andrew Brown; Brown 3Leeds Electron Microscopy...
Results are presented from X-ray absorption spectroscopy based analysis of As, Cr, and V speciation within samples bauxite ore processing residue (red mud) collected the spill site at Ajka, Western Hungary. Cr K-edge XANES found that is present as Cr(3+) substituted into hematite, consistent with TEM analysis. spectra have E(1/2) position pre-edge features presence V(5+) species, possibly associated Ca-aluminosilicate phases. As identified As(5+). EXAFS reveals arsenate phases in red mud...
Abstract Mechanisms for cellular uptake of nanoparticles have important implications nanoparticulate drug delivery and toxicity. We explored the mechanism amorphous silica 14 nm diameter, which agglomerate in culture medium to hydrodynamic diameters around 500 nm. In HT29, HaCat A549 cells, cytotoxicity was observed at nanoparticle concentrations ≥ 1 μg/ml, but DNA damage evident 0.1 μg/ml above. Transmission electron microscopy (TEM) combined with energy-dispersive X-ray spectroscopy...
Ferritin, the major iron storage protein, has dual functions; it sequesters redox activity of intracellular and facilitates turn-over. Here we present high angle annular dark field (HAADF) images from individual hepatic ferritin cores within tissue sections, these were obtained using spherical aberration corrected scanning transmission electron microscopy (STEM) under controlled fluence. HAADF suggest a cubic morphology polycrystalline (ferrihydrite) subunit structure that is not evident in...
The size-dependent nature of the molar extinction coefficient highly photoluminescent copper indium sulfide (CuInS2) quantum dots (CIS-QDs) is presented. We determined coefficients at both high photon energy (3.1 eV) and first excitonic transition band for CIS-QDs, ranging in size from 2.5 nm to 5.1 nm. Both trends displayed a power-law dependence QDs. These data allow situ assessment CIS-QD concentration via routine optical absorption measurements, which an important parameter many...
Osimertinib has shown promising activity in patients with leptomeningeal metastases (LMs) of EGFR-positive NSCLC at 160 mg once daily (qd) (BLOOM; NCT02228369). We report LM osimertinib (80 qd) a retrospective analysis studies across the AURA program (AURA extension, AURA2, AURA17, and AURA3).Patients EGFR T790M-positive advanced progression after previous EGFR-tyrosine kinase inhibitor therapy received qd). Patients central nervous system (CNS) (including LMs) were eligible if lesions...
Powders of CaO sorbent modified with CaZrO3 have been synthesized by a wet chemical route. For carbonation and calcination conditions relevant to sorbent-enhanced steam reforming applications, powder composition 10 wt % CaZrO3/90 showed an initial rise in CO2 uptake capacity the first carbonation–decarbonation cycles, increasing from 0.31 g CO2/g cycle 1 0.37 stabilizing at this value for remainder 30 cycles tested, 650 °C 15% 800 air. Under more severe 950 100% CO2, following best overall...
Abstract 2D metal nanomaterials offer exciting prospects in terms of their properties and functions. However, the ambient aqueous synthesis atomically‐thin, metallic represents a significant challenge. Herein, freestanding atomically‐thin gold nanosheets with thickness only 0.47 nm (two atomic layers thick) are synthesized via one‐step approach at 20 °C, using methyl orange as confining agent. Owing to high surface‐area‐to‐volume ratio, abundance unsaturated atoms exposed on surface large...
Abstract Organic molecular crystals encompass a vast range of materials from pharmaceuticals to organic optoelectronics, proteins and waxes in biological industrial settings. Crystal defects grain boundaries dislocations are known play key roles mechanisms growth 1,2 the functional properties 3–5 . In contrast precise analysis individual metals, ceramics inorganic semiconductors enabled by electron microscopy, substantially greater ambiguity remains experimental determination dislocation...
It is well known that the vulnerable atheromatous plaque has a thin, fibrous cap and large lipid core with associated inflammation. This inflammation can be detected on MRI use of contrast medium, Sinerem, an ultrasmall superparamagnetic iron oxide (USPIO). Although incidence macrophage activity in asymptomatic disease appears low, we aimed to explore MRI-defined plaques patients contralateral symptomatic disease.Twenty underwent multisequence before 36 hours after USPIO infusion. Images...
Electron energy loss spectroscopy (EELS) in the transmission electron microscope (TEM) is explored as a useful characterization technique study of carbonization and graphitization organic precursors. A model series carbon materials was prepared from highly graphitizable petroleum pitch heat treated range 200–2730°C. Initial performed using established techniques X-ray diffraction (XRD), He pycnometry, TEM, high-resolution lattice imaging (HREM). EELS TEM then examined. Two routes are...