A5063377564- Aortic aneurysm repair treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Cerebrovascular and Carotid Artery Diseases
- Aortic Disease and Treatment Approaches
- Vascular Procedures and Complications
- Acute Ischemic Stroke Management
- Intracranial Aneurysms: Treatment and Complications
- Peripheral Artery Disease Management
- Infectious Aortic and Vascular Conditions
- Cardiovascular Health and Disease Prevention
- Antiplatelet Therapy and Cardiovascular Diseases
- Venous Thromboembolism Diagnosis and Management
- Infective Endocarditis Diagnosis and Management
- Cardiac Valve Diseases and Treatments
- Diabetic Foot Ulcer Assessment and Management
- Wound Healing and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Pressure Ulcer Prevention and Management
- Atherosclerosis and Cardiovascular Diseases
- Renal and Vascular Pathologies
- Central Venous Catheters and Hemodialysis
- Hemostasis and retained surgical items
- Protease and Inhibitor Mechanisms
- Surgical site infection prevention
- Surgical Simulation and Training
Addenbrooke's Hospital
2008-2019
Cambridge University Hospitals NHS Foundation Trust
2009-2019
University of Cambridge
2008-2019
University of Saskatchewan
1998-2018
Royal University Hospital
1998-2017
Royal Australian College of General Practitioners
2016
St. Paul's Hospital
2011-2015
Southeast University
2010
University of Leicester
1999-2009
Leicester Royal Infirmary
1999-2009
Postoperative thromboembolic stroke affects 2% to 3% of patients undergoing carotid endarterectomy (CEA) and is preceded by 1 2 hours increasing cerebral embolization. Previous work has demonstrated that high rates postoperative embolization are associated with increased platelet reactivity adenosine 5'-diphosphate (ADP). Our hypothesis was preoperative administration the ADP antagonist clopidogrel could reduce embolization.One hundred CEA on routine aspirin therapy (150 mg) were randomized...
Arterial pCO2 is known to influence cerebral autoregulation but its effect on the dynamic relationship between mean arterial blood pressure (ABP) and flow velocity (CBFV), obtained from spontaneous fluctuations in ABP, has not been established. In 16 normal subjects, ABP was measured non-invasively (Finapres), CBFV estimated with Doppler ultrasound middle artery, end-tidal CO2 (EtCO2) an infrared capnograph. Recordings were made before, during after breathing a mixture of 5% air. The...
Fenestrated endovascular repair of abdominal aortic aneurysms has been proposed as an alternative to open surgery for juxtarenal and pararenal aneurysms. At present, the evidence base this procedure is predominantly limited single-center or single-operator series. The aim study was present nationwide early results fenestrated in United Kingdom.All patients who underwent between January 2007 December 2010 at experienced institutions Kingdom(>10 procedures) were retrospectively studied by use...
Abstract Background Frailty is a multidimensional vulnerability resulting from age-associated decline. The impact of frailty on outcomes was assessed in cohort vascular surgical patients. Methods study included patients aged over 65 years with length hospital stay (LOS) greater than 2 days, who were admitted to tertiary unit single calendar year. Demographics, mode admission, diagnosis, mortality, LOS and discharge destination recorded, as well variety frailty-specific characteristics. LOS,...
Informed consent relies on patients' ability to understand risk information. Evidence suggests that people may extract the gist of any information make medical decisions. Existing evidence also there is an inverse relationship between perception and benefit.Seventy-one patients waiting list for carotid endarterectomy (CEA) were surveyed regarding their understanding recall benefit health undergoing CEA. Patients 1 month after initial consultation, a subgroup was again day before...
To report a randomized clinical trial designed to determine if remote ischemic preconditioning (IP) has the ability reduce renal and cardiac damage following endovascular aneurysm repair (EVAR).Forty patients (all men; mean age 76+/-7 years) with abdominal aortic aneurysms averaging 6.3+/-0.8 cm in diameter were enrolled from November 2006 January 2008. Eighteen (mean 74 years, range 72-81) completed full IP protocol; there no withdrawals. Twenty-two 76 66-80) assigned control group. Remote...
Aneurysm expansion rate is an important indicator of the potential risk abdominal aortic aneurysm (AAA) rupture. Stress within AAA wall also thought to be a trigger for its However, association between stresses and unclear.Forty-four patients with AAAs were included in this longitudinal follow-up study. They assessed by serial ultrasonography computed tomography scans if critical size was reached or rapid occurred. Patient-specific 3-dimensional geometries reconstructed from images....
To report the early and 12-month results of a global registry patients treated with endovascular aneurysm sealing (EVAS) for abdominal aortic aneurysms (AAAs).The EVAS FORWARD Global Registry was postmarket, multicenter, open-label, single-arm that enrolled 277 (mean age 75 years; 228 men) Nellix system nonruptured AAAs at 18 sites over 1-year period. The cohort had challenging anatomy, 17% having proximal neck length <10 mm, 8% angulation >60°, 20% an iliac diameter >25 mm. Baseline...
This study determined whether in vivo positron emission tomography (PET) of arterial inflammation (18F-fluorodeoxyglucose [18F-FDG]) or microcalcification (18F-sodium fluoride [18F-NaF]) could predict restenosis following PTA. Restenosis lower limb percutaneous transluminal angioplasty (PTA) is common, unpredictable, and challenging to treat. Currently, it impossible which patient will suffer from angioplasty. In this prospective observational cohort study, 50 patients with symptomatic...
The contributions of beat-to-beat changes in mean arterial blood pressure (MABP) and breath-by-breath fluctuations end-tidal CO/sub 2/ (EtCO/sub 2/) as determinants the spontaneous variability cerebral flow velocity (CBFV) were studied 16 normal subjects at rest. two input variables (MABP EtCO/sub had significant cross-correlations with CBFV but not between them. Transfer functions estimated multivariate least square finite impulse response causal filters. MABP showed a very effect...