A5021655504- Aortic aneurysm repair treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Aortic Disease and Treatment Approaches
- Infectious Aortic and Vascular Conditions
- Vascular Procedures and Complications
- Cerebrovascular and Carotid Artery Diseases
- Surgical Simulation and Training
- Cardiac Valve Diseases and Treatments
- Renal and Vascular Pathologies
- Intracranial Aneurysms: Treatment and Complications
- Patient Safety and Medication Errors
- Peripheral Artery Disease Management
- Soft Robotics and Applications
- Acute Ischemic Stroke Management
- Venous Thromboembolism Diagnosis and Management
- Healthcare Quality and Management
- Coronary Interventions and Diagnostics
- Central Venous Catheters and Hemodialysis
- Cardiovascular Health and Disease Prevention
- Healthcare Policy and Management
- Congenital Heart Disease Studies
- Hemodynamic Monitoring and Therapy
- Abdominal vascular conditions and treatments
- Radiation Dose and Imaging
- Patient Satisfaction in Healthcare
Imperial College London
2016-2025
Imperial College Healthcare NHS Trust
2015-2024
St Mary's Hospital
2014-2024
St. Mary's Hospital
2012-2024
St. Mary’s Hospital
2009-2024
University of Birmingham
2024
St Mary's Hospital
2004-2024
Universidad de Londres
2022
NIHR Imperial Biomedical Research Centre
2014-2021
Ann Arbor Center for Independent Living
2020
Nuclear factor κB (NF-κB) activation has been observed in human atherosclerotic plaques and is enhanced unstable coronary plaques, but whether such a protective or pathophysiological role remains to be determined. We addressed this question by developing short-term culture system of cells isolated from tissue, allowing efficient gene transfer directly investigate signaling pathways atherosclerosis. found that NF-κB activated these activity involves p65, p50, c-Rel not p52 RelB. This can...
Fenestrated endovascular repair of abdominal aortic aneurysms has been proposed as an alternative to open surgery for juxtarenal and pararenal aneurysms. At present, the evidence base this procedure is predominantly limited single-center or single-operator series. The aim study was present nationwide early results fenestrated in United Kingdom.All patients who underwent between January 2007 December 2010 at experienced institutions Kingdom(>10 procedures) were retrospectively studied by use...
Healthcare professionals can be seriously affected when they are involved in major clinical incidents. The impact of such incidents on staff is particular relevance to surgery, as the operating room one highest-risk areas for serious complications. This qualitative study aimed assess personal and professional surgical complications surgeons.This single time point semistructured, individual interviews with general vascular surgeons, consultants senior registrars from two National Health...
Aortic dissection is the most common acute catastrophic event affecting thoracic aorta. The majority of patients presenting with an uncomplicated type B are treated medically, but 25% these develop subsequent aneurysmal dilatation This study aimed at gaining more detailed knowledge flow phenomena associated this condition. Morphological features and patterns in a dissected aortic segment presurgery patient were analyzed based on computed tomography images acquired from patient. Computational...
The AARDVARK (Aortic Aneurysmal Regression of Dilation: Value ACE-Inhibition on RisK) trial investigated whether ACE-inhibition reduces small abdominal aortic aneurysms (AAA) growth rate, independent blood pressure (BP) lowering. A three-arm, multi-centre, single-blind, and randomized controlled (ISRCTN51383267) was conducted in 14 hospitals England. Subjects aged ≥55 years with AAA diameter 3.0–5.4 cm were 1:1:1 to receive perindopril arginine 10 mg, or amlodipine 5 placebo followed 3–6...
Master-slave systems for endovascular catheterization have brought major clinical benefits including reduced radiation doses to the operators, improved precision and stability of instruments, as well procedural duration. Emerging deep reinforcement learning (RL) technologies could potentially automate more complex tasks with enhanced success rates, consistent motion fatigue cognitive workload operators. However, complexity pulsatile flows within vasculature non-linear behavior instruments...
Endoleaks represent one of the main complications after endovascular aortic repair (EVAR) and can lead to increased re-intervention rates secondary rupture. Serial lifelong surveillance is required traditionally involves cross-sectional imaging with manual axial measurements. Artificial intelligence (AI)-based analysis has been developed may provide a more precise faster assessment. This study aims evaluate ability an AI-based software assess post-EVAR morphological changes over time, detect...
Endovascular intervention is limited by two-dimensional intraoperative imaging and prolonged procedure times in the presence of complex anatomies. Robotic catheter technology could offer benefits such as reduced radiation exposure to clinician improved intravascular navigation. Incorporating three-dimensional preoperative into a semiautonomous robotic catheterization platform has potential for safer more precise This paper discusses based on previous work (Rafii-Tari et al., in: MICCAI2013,...
Despite the increasing popularity of endovascular intervention in clinical practice, there remains a lack objective and quantitative metrics for skill evaluation techniques. Data relating to forces exerted during procedures behavioral patterns clinicians is currently limited. This research proposes two platforms measuring tool applied by operators contact resulting from catheter–tissue interactions, as means providing accurate, operator within realistic simulation environment. Operator...
Endovascular treatment is not recommended for aortic pathologies in patients with connective tissue diseases (CTDs) other than redo operations and as bridging procedures emergencies. However, recent developments endovascular technology may challenge this dogma.