A5050670738- Aortic aneurysm repair treatments
- Aortic Disease and Treatment Approaches
- Cardiac, Anesthesia and Surgical Outcomes
- Infectious Aortic and Vascular Conditions
- Cardiac Valve Diseases and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Vascular Procedures and Complications
- Peripheral Artery Disease Management
- Cardiovascular Function and Risk Factors
- Intracranial Aneurysms: Treatment and Complications
- Hip and Femur Fractures
- Pulmonary Hypertension Research and Treatments
- Acute Ischemic Stroke Management
- Atherosclerosis and Cardiovascular Diseases
- Abdominal vascular conditions and treatments
- Diabetic Foot Ulcer Assessment and Management
- Cardiomyopathy and Myosin Studies
- Infective Endocarditis Diagnosis and Management
- Congenital Diaphragmatic Hernia Studies
- Peroxisome Proliferator-Activated Receptors
- Cholesterol and Lipid Metabolism
- Reproductive tract infections research
- Renal and Vascular Pathologies
- Inflammatory mediators and NSAID effects
- Vascular Anomalies and Treatments
Imperial College London
2014-2025
Imperial College Healthcare NHS Trust
2015-2025
Royal Alexandra Hospital
2025
University of Alberta
2025
St Mary's Hospital
2013-2023
National Health Service
2011-2023
St. Mary's Hospital
2010-2022
St Mary's Hospital
2008-2021
University of Oxford
2021
Ann Arbor Center for Independent Living
2020
Aortic dissection is the most common acute catastrophic event affecting thoracic aorta. The majority of patients presenting with an uncomplicated type B are treated medically, but 25% these develop subsequent aneurysmal dilatation This study aimed at gaining more detailed knowledge flow phenomena associated this condition. Morphological features and patterns in a dissected aortic segment presurgery patient were analyzed based on computed tomography images acquired from patient. Computational...
Aortic dissection causes splitting of the aortic wall layers, allowing blood to enter a ‘false lumen’ (FL). For type B dissection, significant predictor patient outcomes is patency or thrombosis FL. Yet, no methods are currently available assess chances FL thrombosis. In this study, we present new computational model that capable predicting thrombus formation, growth and its effects on flow under physiological conditions. Predictions formation based fluid shear rate, residence time platelet...
Abstract Background Takayasu arteritis (TA) predisposes to the development of arterial stenoses and aneurysms, is associated with considerable morbidity mortality amongst young patients. The aims this study were analyse indications outcomes surgical intervention, assess potential benefits immunosuppression use perioperative imaging. Methods This was a retrospective review patients TA referred between 2001 2012. Results A series 97 TA, seen at single tertiary centre, reported....
Endovascular treatment is not recommended for aortic pathologies in patients with connective tissue diseases (CTDs) other than redo operations and as bridging procedures emergencies. However, recent developments endovascular technology may challenge this dogma.
To the Editors: Ambrisentan, bosentan and sitaxentan are endothelin receptor antagonist (ERA) drugs approved for treatment of patients with pulmonary arterial hypertension (PAH) included in algorithm 2009 (PH) guidelines European Society Cardiology (ESC) Respiratory (ERS) 1. Hepatotoxicity is a frequent side-effect ERA therapy, which contra-indicated mild to severe hepatic impairment (Child–Pugh class B–C) elevated serum aminotransferases prior initiation treatment. In addition, liver...
Silent cerebral infarction is brain injury detected incidentally on imaging; it can be associated with cognitive decline and future stroke. This study investigated embolization, silent neurocognitive following thoracic endovascular aortic repair (TEVAR).Patients undergoing elective or emergency TEVAR at Imperial College Healthcare NHS Trust Guy's St Thomas' Foundation between January 2012 April 2015 were recruited. Aortic atheroma graded from 1 (normal) to 5 (mobile atheroma) was evaluated...
The ATP-binding cassette transporter A1 (ABCA1) facilitates cholesterol efflux from cells, a key process in reverse transport. Whereas previous investigations focused on mutations causing impaired ABCA1 function, we assessed the role of human carotid atherosclerotic disease.We compared mRNA and protein levels ABCA1, one its regulators, liver X receptor alpha (LXRalpha), between minimally grossly arterial tissue. We established LXRalpha gene expression by real-time quantitative polymerase...
Abstract Aims To assess efficacy of conservative management neuropathic forefoot ulcers with underlying osteomyelitis in subjects diabetes when magnetic resonance imaging (MRI) is used to confirm or establish diagnosis and guide antibiotic duration. Methods A retrospective cohort study over 6 years assessing rates ulcer healing, relapse amputation. Antibiotics were continued for 3‐month cycles interval MRI: if the lesion had healed bone signal change resolved improved, antibiotics...
Purpose: To evaluate the short- and long-term outcomes of hybrid repair arch proximal descending aorta in a single tertiary center for aortic disease. Methods: A retrospective analysis was performed 55 patients (median age 67 years; 36 men) who underwent thoracic pathology with involvement between January 2005 May 2015 at center. The pathologies included 40 (73%) aneurysmal disease, 10 (18%) acute type B dissections, 2 syndrome, an dissection, left aberrant right subclavian artery aneurysms....