A5018585563- Aortic aneurysm repair treatments
- Vascular Procedures and Complications
- Peripheral Artery Disease Management
- Cardiac, Anesthesia and Surgical Outcomes
- Cerebrovascular and Carotid Artery Diseases
- Aortic Disease and Treatment Approaches
- Acute Ischemic Stroke Management
- Venous Thromboembolism Diagnosis and Management
- Infectious Aortic and Vascular Conditions
- Cardiovascular Health and Disease Prevention
- Renal and Vascular Pathologies
- Pelvic and Acetabular Injuries
- Hemodynamic Monitoring and Therapy
- Hip and Femur Fractures
- Diabetic Foot Ulcer Assessment and Management
- Coronary Interventions and Diagnostics
- Bone fractures and treatments
- Vascular anomalies and interventions
- Central Venous Catheters and Hemodialysis
- Intracranial Aneurysms: Treatment and Complications
- Protease and Inhibitor Mechanisms
- Abdominal vascular conditions and treatments
- Diagnosis and Treatment of Venous Diseases
- Non-Invasive Vital Sign Monitoring
- Optical Imaging and Spectroscopy Techniques
University Medical Center Groningen
2018-2025
University of Groningen
2020-2025
Radboud University Nijmegen
2008-2023
United States Nuclear Regulatory Commission
2023
Radboud University Medical Center
2023
St. Antonius Ziekenhuis
2013-2022
Clinical Orthopaedics and Related Research
2020
Committee on Publication Ethics
2020
Maastricht University
2017
University Medical Center Utrecht
2005-2016
Identification of patients at risk for primary and secondary manifestations atherosclerotic disease progression is based mainly on established factors. The plaque composition thought to be an important determinant acute cardiovascular events, but no prospective studies have been performed. objective the present study was investigate whether associated with occurrence future vascular events.Atherosclerotic carotid lesions were collected from who underwent endarterectomy subjected histological...
To score the number of plaque neutrophils and relate to morphology inflammatory status.Neutrophils are cells with tissue destruction capabilities that have been found at site an atherosclerotic rupture or erosion. Poor evidence exists for neutrophil infiltration in human carotid plaques, its association has not yet described. A set 355 plaques was stained marker CD66b. High numbers were a large lipid core, high macrophage numbers, low collagen amount smooth muscle cell numbers. associated...
BackgroundA direct comparison of severe acute respiratory syndrome coronavirus 2 positive patients with a negative control group undergoing an operative intervention during the current pandemic is lacking, and reliable estimate assumed difference in morbidity mortality between both patient categories remains unknown.MethodsWe included all consecutive confirmed pre- or postoperative status (operated 27 hospitals) 4 emergency elective operations. A propensity score-matched clinical outcomes...
Time-dependent trends in the incidence of cardiovascular disease have been reported high-income countries. Because atherosclerosis underlies majority diseases, we investigated temporal changes composition atherosclerotic plaques removed from patients undergoing carotid endarterectomy.The Athero-Express study is an ongoing, longitudinal, vascular biobank that includes collection primary endarterectomy province Utrecht 2002 to 2011. Histopathologic features 1583 were analyzed intervals 2...
AimsThere is an increasing need for translational studies identifying molecular targets contributing to atherosclerotic plaque destabilization. Local markers that are related vulnerability may hold predictive value identify patients who at increased risk suffer from cardiovascular events. Animal revealed adipocyte fatty acid binding protein (FABP4) associated with the progression of atherosclerosis; however, FABP4 expression in human plaques lacking. We investigated carotid lesions relation...
Atherosclerotic plaque rupture can lead to severe complications such as myocardial infarction and stroke. Myeloid related protein (Mrp)-14, Mrp-8, Mrp-8/14 complex are inflammatory markers associated with infarction. It is, however, unknown whether Mrps a rupture-prone phenotype. In this study, we determined the association between Mrp-14, -8, -8/14 levels characteristics.In 186 human carotid plaques, of were quantified using ELISA. High Mrp-14 found in lesions large lipid core, high...
Clinical outcomes reported after treatment of infrapopliteal lesions with drug-eluting stents (DESs) have been more favorable compared percutaneous transluminal angioplasty a bailout bare metal stent (PTA-BMS) through midterm follow-up in patients critical limb ischemia. In the present study, long-term results DESs are presented.Adults ischemia (Rutherford category ≥4) and were randomized to receive PTA-BMS or paclitaxel. Long-term consisted annual assessments up 5 years until clinical end...
Background— Endovascular infrapopliteal treatment of patients with critical limb ischemia using percutaneous transluminal angioplasty (PTA) and bail-out bare metal stenting (BMS) is hampered by restenosis. In interventional cardiology, drug-eluting stents (DES) have shown better patency rates are standard practice nowadays. An investigator-initiated, multicenter, randomized trial was conducted to assess whether DES also improve clinical outcome lesions. Methods Results— Adults (Rutherford...
Recent randomized trials showed an increased periprocedural risk for stroke with increasing age in patients undergoing carotid artery stenting. Manipulation of atherosclerotic plaques during stenting can result plaque rupture subsequent superimposed thrombus formation, embolization, and cerebrovascular events. We hypothesized that become more unstable thereby might provide insight into the age-related events stenting.Carotid were harvested from 1385 consecutive endarterectomy between 2002...
Although never assessed prospectively, diabetes mellitus (DM) is assumed to negatively affect the outcomes of critical limb ischemia (CLI). DM was highly prevalent in two recently conducted randomized controlled trials CLI patients, PADI (Percutaneous Transluminal Balloon Angioplasty [PTA] and Drug Eluting Stents for Infrapopliteal Lesions Critical Limb Ischemia) JUVENTAS (Rejuvenating Endothelial Progenitor Cells via Transcutaneous Intra-Arterial Supplementation) trials. To determine...
To report the early and 12-month results of a global registry patients treated with endovascular aneurysm sealing (EVAS) for abdominal aortic aneurysms (AAAs).The EVAS FORWARD Global Registry was postmarket, multicenter, open-label, single-arm that enrolled 277 (mean age 75 years; 228 men) Nellix system nonruptured AAAs at 18 sites over 1-year period. The cohort had challenging anatomy, 17% having proximal neck length <10 mm, 8% angulation >60°, 20% an iliac diameter >25 mm. Baseline...
<h3>Importance</h3> Prevention of postcontrast acute kidney injury in patients with stage 3 chronic disease (CKD) by means prehydration has been standard care for years. However, evidence the need this group is limited. <h3>Objective</h3> To assess renal safety omitting prophylactic prior to iodine-based contrast media administration CKD. <h3>Design, Setting, and Participants</h3> The Kompas trial was a multicenter, noninferiority, randomized clinical conducted at 6 hospitals Netherlands...
Continuous telemonitoring of vital signs in a clinical or home setting may lead to improved knowledge patients' baseline and earlier detection patient deterioration, it also facilitate the migration care toward home. Little is known about performance available wearable sensors, especially during daily life activities, although accurate technology critical for decision-making.The aim this study assess data availability, accuracy, concurrent validity sign measured with sensors volunteers...
Abstract Purpose There is a debate whether corrective osteotomies of the distal radius should be performed using 3D work-up with pre-contoured conventional implants (i.e., of-the-shelf) or patient-specific custom-made). This study aims to assess postoperative accuracy 3D-assisted correction osteotomy either implant. Methods Twenty were planned technologies and on Thiel embalmed human cadavers. Our workflow consisted virtual surgical planning printed guides for repositioning. Subsequently,...