Jan Albert Vos
A5009172577- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Peripheral Artery Disease Management
- Aortic aneurysm repair treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Vascular Procedures and Complications
- Stroke Rehabilitation and Recovery
- Intracranial Aneurysms: Treatment and Complications
- Aortic Disease and Treatment Approaches
- Cardiovascular Health and Disease Prevention
- Cardiac, Anesthesia and Surgical Outcomes
- Sports Performance and Training
- Infectious Aortic and Vascular Conditions
- Vascular Anomalies and Treatments
- Tracheal and airway disorders
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac Valve Diseases and Treatments
- Pulmonary Hypertension Research and Treatments
- Coronary Interventions and Diagnostics
- Intracerebral and Subarachnoid Hemorrhage Research
- Central Venous Catheters and Hemodialysis
- Muscle activation and electromyography studies
- Body Composition Measurement Techniques
- Renal and Vascular Pathologies
St. Antonius Ziekenhuis
2015-2024
Health and Education Research Management and Epidemiologic Services (United States)
2021-2023
Charité - Universitätsmedizin Berlin
2023
Jeroen Bosch Ziekenhuis
2023
Ghent University Hospital
2023
Kantonsspital Winterthur
2023
University Medical Center Utrecht
2002-2021
Hermes Arzneimittel (Germany)
2021
Erasmus MC
2015-2020
Maasstad Ziekenhuis
2020
In patients with acute ischemic stroke caused by a proximal intracranial arterial occlusion, intraarterial treatment is highly effective for emergency revascularization. However, proof of beneficial effect on functional outcome lacking.
The effectiveness of endovascular therapy in patients with stroke caused by basilar-artery occlusion has not been well studied.We randomly assigned within 6 hours after the estimated time onset a due to occlusion, 1:1 ratio, receive or standard medical care. primary outcome was favorable functional outcome, defined as score 0 3 on modified Rankin scale (range, 6, indicating no disability, moderate and death) at 90 days. safety outcomes were symptomatic intracranial hemorrhage days initiation...
Recent randomized trials have proven the benefit of intra-arterial treatment (IAT) with retrievable stents in acute ischemic stroke. Patients poor or absent collaterals (preexistent anastomoses to maintain blood flow case a primary vessel occlusion) may gain less clinical from IAT. In this post hoc analysis, we aimed assess whether effect IAT was modified by collateral status on baseline computed tomographic angiography Multicenter Randomized Clinical Trial Endovascular Treatment Acute...
Intra-arterial treatment (IAT) for acute ischemic stroke caused by intracranial arterial occlusion leads to improved functional outcome in patients treated within 6 hours after onset. The influence of delay on effect is not yet known.To evaluate the time from onset start and reperfusion IAT.The Multicenter Randomized Clinical Trial Endovascular Treatment Acute Ischemic Stroke Netherlands (MR CLEAN) was a multicenter, randomized clinical open-label trial IAT vs no 500 patients. defined as...
Introduction We related composition of cerebral thrombi to stroke subtype and attenuation on non-contrast CT (NCCT) gain more insight in etiopathogenesis validate thrombus as a new imaging biomarker for acute stroke. Methods histopathologically investigated 22 retrieved after mechanical thrombectomy patients. First, were classified fresh, lytic or organized. Second, percentages red blood cells (RBCs), platelets fibrin number red, white (respectively RBCs outnumbering other components with...
Background: Randomized, clinical trials in selected acute ischemic stroke patients reported that for every hour delay of endovascular treatment (EVT), chances functional independence diminish by up to 3.4%. These findings may not be fully generalizable practice because strict in- and exclusion criteria these trials. Therefore, we aim assess the association time EVT with outcome current, everyday practice. Methods: The MR CLEAN Registry (Multicenter Randomized Clinical Trial Endovascular...
Background and Purpose- The modified Rankin Scale (mRS) at 3 months is the most commonly used primary outcome measure in stroke treatment trials, but it lacks specificity requires long-term follow-up interviews, which consume time resources. An alternative may be National Institutes of Health Stroke (NIHSS), early after stroke. Our aim was to evaluate whether NIHSS assessed within 1 week could serve as a for trials acute ischemic Methods- We data from 2 randomized controlled endovascular...
The value of administering intravenous alteplase before endovascular treatment (EVT) for acute ischemic stroke has not been studied extensively, particularly in non-Asian populations.
Information about habitual food intake was systematically obtained from elite endurance, strength, and team sport athletes. The athletes (n = 419) trained at least 1-2 h daily competed on an international level. A 4- or 7-day diary kept. For analysis of the data, a computerized table used. Mean energy varied 12.1-24.7 MJ per day for male 6.8-12.9 female Protein in agreement with higher than Dutch recommendations. Contribution carbohydrate to total 40%-63%. Fat tended meet criteria prudent...
Background and Purpose— Intra-arterial treatment (IAT) in patients with acute ischemic stroke (AIS) can be performed or without general anesthesia (GA). Previous studies suggested that IAT the use of GA (non-GA) is associated better clinical outcome. Nevertheless, no consensus exists about anesthetic management during AIS patients. This study investigates association between type outcome a large cohort treated IAT. Methods— All consecutive anterior circulation who received 2002 2013 16 Dutch...
Abstract Background Despite recent advances in acute stroke treatment, basilar artery occlusion (BAO) is associated with a death or disability rate of close to 70%. Randomised trials have shown the safety and efficacy intravenous thrombolysis (IVT) given within 4.5 h promising results intra-arterial 6 symptom onset ischaemic stroke, but these do not directly apply patients an BAO because only few, if any, were included randomised trials. Recently Basilar Artery International Cooperation...
<h3>Background:</h3> The aim of the current study was to assess influence anesthetic management on effect treatment in Multicenter Randomized Clinical Trial Endovascular Treatment for Acute Ischemic Stroke Netherlands (MR CLEAN). <h3>Methods:</h3> MR CLEAN a multicenter, randomized, open-label trial intra-arterial therapy (IAT) vs no IAT. intended at start procedure used this post hoc analysis. primary parameter adjusted common odds ratio (acOR) shift direction better outcome modified Rankin...
Preclinical studies showed that thrombi can be permeable and may, therefore, allow for residual blood flow in occluded arteries of patients having acute ischemic stroke. This perviousness may increase tissue oxygenation, improve thrombus dissolution, augment intra-arterial treatment success. We hypothesize the combination computed tomographic angiography noncontrast tomography imaging allows measurement contrast agent penetrating a thrombus, it is associated with improved outcome.Thrombus...
High blood pressure (BP) is associated with poor outcome and the occurrence of symptomatic intracranial hemorrhage in acute ischemic stroke. Whether BP influences benefit or safety intra-arterial treatment (IAT) not known. We aimed to assess relation functional outcome, effect IAT.This a post hoc analysis MR CLEAN (Multicenter Randomized Clinical Trial Endovascular Treatment Acute Ischemic Stroke Netherlands). was measured at baseline, before IAT stroke unit admission. estimated association...
Background and Purpose— Due to chronic hypoperfusion, cervical atherosclerosis may promote cerebral collateral circulation. We hypothesized that patients with ischemic stroke due carotid have a more extensive circulation better outcomes than cardioembolism. tested this hypothesis in population of who underwent endovascular treatment for large vessel occlusion. Methods— From the MR-CLEAN Registry (Multicenter Randomized Controlled Trial Endovascular Treatment Acute Ischemic Stroke...
Our aim was to assess the prognostic value of a semiquantitative computed tomography angiography-based grading system, for prediction outcome in patients with acute basilar artery occlusion, based on presence potential collateral pathways angiography: posterior circulation score (PC-CS).One hundred forty-nine occlusion from Basilar Artery International Cooperation Study were included. We related poor at one month, defined as modified Rankin scale 4 or 5, death flow Poisson regression. used...
The utility of computed tomographic perfusion (CTP)-based patient selection for intra-arterial treatment acute ischemic stroke has not been proven in randomized trials and requires further study a cohort that was selected based on CTP. Our objective to the relationship between CTP-derived parameters outcome effect patients with because proximal intracranial arterial occlusion.We included 175 who underwent CTP Multicenter Randomized Clinical Trial Endovascular Treatment Acute Ischemic Stroke...
Background and Purpose- The location of the thrombus as observed on first digital subtraction angiography during endovascular treatment may differ from initial observation noninvasive imaging. We studied incidence dynamics, its impact patient outcomes, association with intravenous thrombolytics. Methods- included patients MR CLEAN registry (Multicenter Randomized Clinical Trial Endovascular Treatment Acute Ischemic Stroke) an target occlusion computed tomography located in intracranial...