A5012392552- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Multiple Sclerosis Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Response and Inflammation
- Monoclonal and Polyclonal Antibodies Research
- Peripheral Neuropathies and Disorders
- Immune Cell Function and Interaction
- Immune cells in cancer
- Gut microbiota and health
- Systemic Lupus Erythematosus Research
- HIV Research and Treatment
- Neurogenesis and neuroplasticity mechanisms
- Glycosylation and Glycoproteins Research
- Psoriasis: Treatment and Pathogenesis
- Hereditary Neurological Disorders
- Dermatology and Skin Diseases
- Probiotics and Fermented Foods
- Cytokine Signaling Pathways and Interactions
- Reproductive System and Pregnancy
- Atherosclerosis and Cardiovascular Diseases
- Cell Adhesion Molecules Research
- Hidradenitis Suppurativa and Treatments
- Colorectal and Anal Carcinomas
- Lysosomal Storage Disorders Research
University Medical Center Groningen
2016-2025
University of Groningen
2016-2025
Biomedical Primate Research Centre
2010-2022
University of Utah
2021
ARUP Laboratories (United States)
2021
Dialyse Centrum Groningen
2021
Verslavingszorg Noord Nederland
2017
Medical University of Vienna
2017
Amsterdam UMC Location Vrije Universiteit Amsterdam
2017
University of Edinburgh
2017
Abstract Topical application of imiquimod (IMQ), a TLR7/8 ligand and potent immune activator, can induce exacerbate psoriasis, chronic inflammatory skin disorder. Recently, crucial role was proposed for the IL-23/IL-17 axis in psoriasis. We hypothesized that IMQ-induced dermatitis mice serve as model analysis pathogenic mechanisms psoriasis-like assessed its dependency. Daily IMQ on mouse back induced inflamed scaly lesions resembling plaque type These showed increased epidermal...
Journal Article Elevated levels of tumour necrosis factor (TNF)‐α, interleukin (IL)‐1β and IL‐10 in hidradenitis suppurativa skin: a rationale for targeting TNF‐α IL‐1β Get access H.H. van der Zee, Zee Departments DermatologyImmunology, Erasmus MC, University Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, the Netherlands Hessel Zee. E‐mail: h.vanderzee@erasmusmc.nl Search other works by this author on: Oxford Academic Google Scholar L. de Ruiter, Ruiter D.G. den Broecke, Broecke...
gp39, the ligand for CD40 expressed on activated CD4+ T helper cells, is required generation of antibody responses to T-dependent (TD) antigens. Treatment mice with anti-gp39 in vivo inhibits both primary and secondary formation TD, but not T-independent However, role this receptor-ligand pair development germinal centers B cell memory as yet undefined. Using an study examines requirement gp39-CD40 interactions induction center formation, well memory. Animals were immunized, treated...
In multiple sclerosis patients, B cells mature in the draining cervical lymph nodes before trafficking across blood-brain barrier.
Mesenchymal or stromal stem cells (MSC) interact with of the immune system in multiple ways. Modulation by MSC is believed to be a therapeutic option for autoimmune disease and transplant rejection. In recent years, B have moved into focus attention as targets treatment disorders. Current B-cell targeting based on indiscriminate depletion cells. The aim this study was examine whether human adipose tissue-derived (ASC) affect their proliferation, differentiation, function. ASC supported...
The development of microglia Microglia are the brain's immune cells, and they play important roles in health neurodegenerative disease. Kracht et al. performed single-cell analysis human microglial gene expression chromatin accessibility compared results with those other studies mice development. By using situ validation, these data identify fetal subsets that appear to be distinct from adult microglia, suggesting functional differences between developing mature brain. Science , this issue p. 530
Abstract We investigated the role of gp39-CD40 interaction in development glomerulonephritis lupus mice. In contrast to normal mice, mice had much higher percentages intensely gp39+ T cells their spleens even at preautoimmune age 1 mo, and further increase gp39 expression by anti-CD3 Ab stimulation was markedly greater cells. The pathogenic autoantibody-inducing ability Th clones splenic from could be blocked vitro anti-gp39 Ab. Acceleration nephritis transfer vivo also completely...
Multiple sclerosis lesion activity concurs with the extent of inflammation, demyelination and axonal suffering. Pro-inflammatory myeloid cells contribute to development, but self-limiting nature lesions implies as yet unidentified anti-inflammatory mechanisms. We addressed hypothesis that myelin ingestion by induces a foamy appearance confers function. First, we show myelin-containing foam in multiple consistently express series molecules while lacking pro-inflammatory cytokines. Second,...
Dendritic cells are thought to regulate tolerance induction vs immunization by transferring Ags and peripheral signals draining lymph nodes (LN). However, whether myelin Ag transfer presentation in LN occurs during demyelinating brain disease is unknown. In this study, we demonstrate redistribution of autoantigens from lesions cervical monkey experimental autoimmune encephalomyelitis (EAE) multiple sclerosis (MS). Immunohistochemical analysis revealed significantly more containing monkeys...
Although the existence of anti-inflammatory alternatively activated macrophages (aamphi) has been accepted widely based on in vitro studies, their vivo location, phenotype, and function still are debated. Gaucher disease (GD) is caused by a genetic deficiency lysosomal enzyme glucocerebrosidase characterized accumulation glycosphingolipids so-called cells (GCs). By using immunohistochemical analysis, we investigated whether this results an aamphi phenotype. GCs macrophage-like cells,...
Although the existence of anti-inflammatory alternatively activated macrophages (aamφ) has been accepted widely based on in vitro studies, their vivo location, phenotype, and function still are debated. Gaucher disease (GD) is caused by a genetic deficiency lysosomal enzyme glucocerebrosidase characterized accumulation glycosphingolipids so-called cells (GCs). By using immunohistochemical analysis, we investigated whether this results an aamφ phenotype. GCs macrophage-like cells, expressing...
Proctocolectomy with ileal pouch-anal anastomosis is the operation of choice for patients refractory or fulminant ulcerative colitis. The most common long-term complication in these pouchitis. This study was designed to investigate efficacy probiotic Lactobacillus rhamnosus GG delaying first onset pouchitis.Between 1989 and 2001, a consecutive series 127 presenting colitis underwent an at Erasmus Medical Center Rotterdam. Histopathologic investigation resected specimens revealed unsuspected...
Primary infection with herpes simplex virus 1 (HSV-1) and varicella zoster (VZV) results in lifelong latent infections of neurons sensory ganglia such as the trigeminal (TG). It has been postulated that T cells retained TG inhibit reactivation virus. The acquisition specimens individuals within hours after death offered unique opportunity to characterize phenotype specificity TG-resident humans. High numbers activated CD8 + expressing a late effector memory were found reside latently...