John A. Brennan

ORCID: 0000-0001-8007-498X
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About
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Research Areas
  • Aortic aneurysm repair treatments
  • Cardiac, Anesthesia and Surgical Outcomes
  • Vascular Procedures and Complications
  • Aortic Disease and Treatment Approaches
  • Peripheral Artery Disease Management
  • Coronary Interventions and Diagnostics
  • Emergency and Acute Care Studies
  • Infectious Aortic and Vascular Conditions
  • Cerebrovascular and Carotid Artery Diseases
  • Venous Thromboembolism Diagnosis and Management
  • Cardiac Valve Diseases and Treatments
  • American History and Culture
  • Renal and Vascular Pathologies
  • Trauma and Emergency Care Studies
  • American Constitutional Law and Politics
  • American Environmental and Regional History
  • Cardiac and Coronary Surgery Techniques
  • Central Venous Catheters and Hemodialysis
  • Advanced X-ray and CT Imaging
  • Healthcare Systems and Technology
  • Colorectal Cancer Surgical Treatments
  • Reconstructive Surgery and Microvascular Techniques
  • Intracranial Aneurysms: Treatment and Complications
  • Aortic Thrombus and Embolism
  • Patient Safety and Medication Errors

Queen Elizabeth University Hospital
2025

Edinburgh College
2024

University of Edinburgh
2024

Lehigh Valley Hospital-Pocono
2023

Lehigh Valley Health Network
2023

Royal Liverpool and Broadgreen University Hospital NHS Trust
2011-2022

National Health Service
2022

Royal Liverpool University Hospital
2007-2021

University of Liverpool
2007-2021

Aintree University Hospitals NHS Foundation Trust
2021

In the ongoing evolution of a categorization system for endoleak, authors propose term endotension to define persistent or recurrent pressurization aortic aneurysm sac after endovascular repair. Endotension is evidence that remains at risk rupture and should, therefore, be considered an indication secondary intervention. Management strategies grading are offered.

10.1583/1074-6218(1999)006<0305:eaeard>2.0.co;2 article EN Journal of Endovascular Surgery 1999-11-01

Fenestrated endovascular repair of abdominal aortic aneurysms has been proposed as an alternative to open surgery for juxtarenal and pararenal aneurysms. At present, the evidence base this procedure is predominantly limited single-center or single-operator series. The aim study was present nationwide early results fenestrated in United Kingdom.All patients who underwent between January 2007 December 2010 at experienced institutions Kingdom(>10 procedures) were retrospectively studied by use...

10.1161/circulationaha.111.070334 article EN Circulation 2012-06-05

To report the incidence of delayed complications following endovascular abdominal aortic aneurysm (AAA) repair and relationship these sequelae to morphological changes in sac endograft.Twenty-six AAA patients treated with Vanguard endografts had completed > or = 1-year follow-up. Postoperative angiograms spiral computed tomographic (CT) scans 3-dimensional reconstruction were compared images determine endograft. These then related occurring between 1 12 months postoperatively study...

10.1583/1074-6218(1999)006<0011:lasfea>2.0.co;2 article EN Journal of Endovascular Surgery 1999-02-01

The outcome of fenestrated endovascular aneurysm repair (F-EVAR) was evaluated.Between February 2003 and December 2006, 45 patients (median age 73 (range 53-85) years) underwent primary (41) or secondary (four) F-EVAR for an abdominal aortic with infrarenal neck anatomy unsuitable a standard stent-graft. Median diameter 68 55-100) mm median length 6 0-13) mm. Customized Zenith stent-grafts were employed in all procedures, incorporating fenestrations to preserve flow into renal (80), superior...

10.1002/bjs.5979 article EN British journal of surgery 2007-10-11

Fenestrated endovascular aneurysm repair (FEVAR) is increasingly being used for juxtarenal aortic aneurysms. The aim of this study was to review long-term results and assess the importance changing stent-graft design on outcomes.This a retrospective all patients who underwent FEVAR within single unit over 12 years (February 2003 December 2015). Kaplan-Meier analysis survival, freedom from target vessel loss, expansion, graft-related endoleak secondary intervention performed. Comparison...

10.1002/bjs.10524 article EN cc-by British journal of surgery 2017-04-12

To measure the tensile strength of aneurysm wall and matrix metalloproteinase (MMP) activity in similar samples aortic tissue.Detailed mechanical testing was conducted on 124 standardized specimens harvested from 24 patients undergoing elective repair. The intrasac pressure required to cause rupture calculated based upon Law Laplace. In addition, MMP-2 9 were assayed these specimens. Sixty nonaneurysmal aorta 6 cadaveric organ donors served as controls. Intrasubject intersubject variations...

10.1583/04-1239.1 article EN Journal of Endovascular Therapy 2004-08-01

The European Union (EU) Medical Device Regulation increased regulatory scrutiny to improve the safety and performance of new medical devices. An equally important goal is providing timely access innovative devices benefit patient care. Society Cardiology strongly advocates for evolution system facilitate priority unmet needs orphan cardiovascular (CV) in EU countries. Although device approval currently executed by Notified Bodies EU, it will be advantageous mid-term consider a single agency...

10.1093/eurheartj/ehaf069 article EN other-oa European Heart Journal 2025-02-20

To compare unenhanced and enhanced ultrasound imaging to biphasic computed tomography (CT) in the detection of endoleak after endovascular abdominal aortic aneurysm (AAA) repair.Fifty-three patients (44 men; mean age 70 years) were examined during 96 follow-up visits AAA repair. All had color Doppler power studies performed before administration an contrast agent. Biphasic (arterial delayed) CT was on same day, independently scored record presence or absence level confidence observation.The...

10.1177/152660280200900206 article EN Journal of Endovascular Therapy 2002-04-01

Although it is well known that cannabinoids produce antinociception in acute pain models, there less information on the ability of to alleviate hyperalgesia. In present study, we determined whether attenuated development hyperalgesia produced by intraplantar injection capsaicin rats. normal, untreated animals, 10 microg produces nocifensive behavior (elevation injected paw) suggestive pain, an increase frequency withdrawal from punctate mechanical stimuli applied paw (mechanical...

10.1016/s0304-3959(98)00263-2 article EN Pain 1999-05-01

The results of 373 infrainguinal bypass grafts, in a single centre, between 1980 and 1988 are reviewed. One hundred thirty situ vein (ISV), 47 reversed saphenous (RSV), 118 polytetrafluoroethylene (PTFE) 78 human umbilical (HUV) grafts were used. indications for surgery disabling claudication 25 per cent patients limb salvage 75 cent. In 36 operations the distal anastomosis was above knee 64 it below knee. Overall 5-year patency rates respectively were, ISV (41 69 cent), RSV (62 90 PTFE (31...

10.1002/bjs.1800771220 article EN British journal of surgery 1990-12-01

To determine whether the introduction of a policy adjunctive stent insertion based on preoperative CT assessment or completion angiography reduced incidence limb occlusion after stent-graft implantation for endovascular aneurysm repair (EVAR).A tertiary referral unit's database was retrospectively interrogated to compare endograft in Zenith grafts following selective insertion. Group A included 288 limbs at risk 146 patients (134 men; mean age 74+/-8 years) treated prior August 2005 whom...

10.1583/09-2854.1 article EN Journal of Endovascular Therapy 2010-02-26
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