A5001482212- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Health and Disease Prevention
- Acute Ischemic Stroke Management
- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Aortic aneurysm repair treatments
- Elasticity and Material Modeling
- Intracranial Aneurysms: Treatment and Complications
- Atherosclerosis and Cardiovascular Diseases
- MRI in cancer diagnosis
- Cardiovascular Disease and Adiposity
- Cardiac, Anesthesia and Surgical Outcomes
- Aortic Disease and Treatment Approaches
- Traumatic Brain Injury and Neurovascular Disturbances
- Glioma Diagnosis and Treatment
- Protease and Inhibitor Mechanisms
- Medical Imaging Techniques and Applications
- Medical Image Segmentation Techniques
- Hospital Admissions and Outcomes
- Vascular Procedures and Complications
- Infectious Aortic and Vascular Conditions
- Aortic Thrombus and Embolism
- Lipoproteins and Cardiovascular Health
The Royal Free Hospital
2023
University College London
2023
University Health Network
2023
Cardiff University
2013-2023
University of Cambridge
2013-2022
Cambridge School
2003-2022
Addenbrooke's Hospital
2010-2019
Engineering and Physical Sciences Research Council
2016-2019
Cambridge University Hospitals NHS Foundation Trust
2008-2018
Papworth Hospital
2004-2016
Studies of the fat-derived hormone leptin have provided key insights into molecular and neural components feeding behavior body weight regulation. An important challenge lies in understanding how rewarding properties food interact with, can override, physiological satiety signals promote overeating. We used functional magnetic resonance imaging to measure brain responses two human patients with congenital deficiency who were shown images before after 7 days replacement therapy. Leptin was...
Inflammation within atherosclerotic lesions contributes to plaque instability and vulnerability rupture. We set out evaluate the use of a macrophage labeling agent identify carotid inflammation by in vivo magnetic resonance imaging (MRI).Thirty patients with symptomatic severe stenosis scheduled for endarterectomy underwent multi-sequence MRI bifurcation before after injection ultrasmall superparamagnetic particles iron oxide (USPIOs). USPIO accumulated macrophages 24 30 plaques (80%). Areas...
Hyperpolarized 13C Magnetic Resonance Imaging (13C-MRI) provides a highly sensitive tool to probe tissue metabolism in vivo and has recently been translated into clinical studies. We report the cerebral of intravenously injected hyperpolarized [1–13C]pyruvate brain healthy human volunteers for first time. Dynamic acquisition images demonstrated 13C-labeling both lactate bicarbonate, catalyzed by cytosolic dehydrogenase mitochondrial pyruvate respectively. This demonstrates that enzymes can...
Background— It has been suggested that inflammatory cells within vulnerable plaques may be visualized by superparamagnetic iron oxide particle-enhanced MRI. The purpose of this study was to determine the time course for macrophage visualization with in vivo contrast-enhanced MRI using an ultrasmall (USPIO) agent symptomatic human carotid disease. Methods— Eight patients scheduled endarterectomy underwent multisequence bifurcation before and 24, 36, 48, 72 hours after Sinerem (2.6 mg/kg)...
Background and Purpose— Carotid endarterectomy is currently guided by angiographic appearance on the assumption that most stenotic lesion visible at angiography likely to be from which future embolic events will arise. However, risk of plaque rupture, common cause atherosclerosis-related thromboembolism, dictated composition plaque, in particular degree inflammation. Angiography may, therefore, an unreliable method identifying vulnerable plaques. In this study, inflammation was quantified...
Background and Purpose— Perfusion magnetic resonance imaging (pMR) is increasingly used in acute stroke, but its physiologic significance still debated. A reasonably good correlation between pMR positron emission tomography (PET) has been reported normal subjects chronic cerebrovascular disease, corresponding validation stroke lacking. Methods— We compared the cerebral blood flow (CBF), volume, mean transit time (MTT) maps generated by (deconvolution method) PET ( 15 O steady-state 5...
Acute cerebral ischemic events are associated with rupture of vulnerable carotid atheroma and subsequent thrombosis. Factors such as luminal stenosis fibrous cap thickness have been thought to be important risk factors for plaque rupture. We used a flow-structure interaction model simulate the between blood flow atheromatous evaluate effect degree on vulnerability.A coupled nonlinear time-dependent flow-plaque simulation was perform stress/strain analysis in stenotic artery model. The stress...
Computational modelling to calculate the mechanical loading within atherosclerotic plaques has been shown be complementary defining anatomical plaque features in determining vulnerability. However, its application partially impeded by lack of comprehensive knowledge about properties various tissues plaque. Twenty-one human carotid were collected from endarterectomy. The was cut into rings, and different type tissues, including media, fibrous cap (FC), lipid intraplaque haemorrhage/thrombus...
Abstract Aims The focal distribution of atherosclerotic plaques suggests that local biomechanical factors may influence plaque development. Methods and results We studied 40 patients at baseline over 12 months by virtual-histology intravascular ultrasound bi-plane coronary angiography. calculated structural stress (PSS), defined as the mean maximum principal peri-luminal region, wall shear (WSS), parallel frictional force exerted blood flow on endothelial surface, in areas undergoing...
PURPOSE: To investigate the evolution of metabolic changes detectable with proton magnetic resonance (MR) spectroscopic imaging in acute stroke and to compare these findings those conventional MR imaging. MATERIALS AND METHODS: A patient middle cerebral artery underwent proton-density (PD)- T2-weighted imaging, angiography, multisection two-dimensional over a period 3 hours 5 months after symptom onset. RESULTS: On 3-hour images, no abnormal signal intensity change was detectable....
Cerebral ischaemia appears to be an important mechanism of secondary neuronal injury in traumatic brain (TBI) and is predictor outcome. To date, the thresholds cerebral blood flow (CBF) oxygen utilization (CMRO(2)) for irreversible tissue damage used TBI studies have been adopted from experimental clinical ischaemic stroke studies. Identification irreversibly damaged acute phase following could considerable therapeutic prognostic implications. However, it questionable whether are applicable...