A5103227870- Advanced MRI Techniques and Applications
- Medical Imaging Techniques and Applications
- Advanced NMR Techniques and Applications
- Reproductive Health and Technologies
- Reproductive Biology and Fertility
- Ovarian function and disorders
- Child and Adolescent Health
- Reproductive System and Pregnancy
- Sperm and Testicular Function
- Adrenal Hormones and Disorders
- Cardiac Fibrosis and Remodeling
- Cancer-related molecular mechanisms research
- Healthcare Systems and Practices
- Cardiovascular Issues in Pregnancy
- Ethics and Legal Issues in Pediatric Healthcare
- Molecular Biology Techniques and Applications
- Prenatal Screening and Diagnostics
- Celiac Disease Research and Management
- Sarcoma Diagnosis and Treatment
- Estrogen and related hormone effects
- Sexual Differentiation and Disorders
- Ethics in medical practice
- Solid-state spectroscopy and crystallography
- MRI in cancer diagnosis
- Bone Tumor Diagnosis and Treatments
Cambridge School
2022
University of Cambridge
2019-2022
Centre Hospitalier Universitaire de Rennes
2008
Université de Rennes
2008
Hôpital Nord
1999-2006
Hôpital Pontchaillou
2005
Université Paris Cité
1985
Inserm
1985
Our purpose is to investigate the feasibility of imaging tumor metabolism in breast cancer patients using 13 C magnetic resonance spectroscopic (MRSI) hyperpolarized label exchange between injected [1- C]pyruvate and endogenous lactate pool. Treatment-naïve were recruited: four triple-negative grade 3 cancers; two invasive ductal carcinomas that estrogen progesterone receptor-positive (ER/PR+) HER2/neu-negative (HER2−), one 2 3; ER/PR+ HER2− lobular carcinoma (ILC). Dynamic MRSI was...
Hyperpolarized 13C Magnetic Resonance Imaging (13C-MRI) provides a highly sensitive tool to probe tissue metabolism in vivo and has recently been translated into clinical studies. We report the cerebral of intravenously injected hyperpolarized [1–13C]pyruvate brain healthy human volunteers for first time. Dynamic acquisition images demonstrated 13C-labeling both lactate bicarbonate, catalyzed by cytosolic dehydrogenase mitochondrial pyruvate respectively. This demonstrates that enzymes can...
To assess the value of magnetic resonance (MR) imaging breast in differentiation late postirradiation fibrosis from recurrent carcinoma, 35 women with a history carcinoma treated conservatively radiation therapy underwent MR imaging. Nine patients had tumors confirmed at biopsy and surgery. Twenty-six localized fibrotic mass and/or during long-term clinical radiologic follow-up. In all cases, hypointense area was present on plain spin-echo T1-weighted images. tumors, dynamic...
Purpose To evaluate glioblastoma (GBM) metabolism by using hyperpolarized carbon 13 (13C) MRI to monitor the exchange of 13C label between injected [1-13C]pyruvate and tumor lactate bicarbonate. Materials Methods In this prospective study, seven treatment-naive patients (age [mean ± SD], 60 years 11; five men) with GBM were imaged at 3 T a dual-tuned 13C–hydrogen 1 head coil. Hyperpolarized was injected, signal acquired dynamic spiral sequence. Metabolism assessed within tumor, in...
We prospectively studied the effects of hormonal modulation using antigonadotropic drug, cyproterone acetate (CA), in 7 female patients who had moderately active systemic lupus erythematosus. CA was taken orally at a mean daily dose 50 mg for 21-33 months by 6 (9 seventh patient) without any side effects. The number clinical exacerbations during treatment lower than that corresponding pretreatment period (15 170 patient-months versus 27 156 patient-months; P less 0.05), despite reduction...
BACKGROUND: Nitric oxide (NO) is involved in local control of the uterine cycle and preparation uterus for pregnancy. NO donors, acting as vasodilating agents, may therefore have possible therapeutic uses, example they be benefit to patients with a history implantation failure. In prospective, comparative, randomized, placebo-controlled study, we assessed efficacy nitroglycerin (NTG) administered 138 IVF METHODS: Controlled ovarian stimulation was performed long agonist protocol combined...
McCune-Albright syndrome (MAS) is characterized by peripheral precocious puberty, café-au-lait spots, and polyostotic fibrous dysplasia. This due to a post-zygotic mutation of the GNAS1 gene with mosaic distribution unilateral predominance. Clinical manifestations depend on tissues carrying mutation. We describe ovarian function before after ovariectomy in woman MAS bilateral mutation.A 33-year-old patient, previously diagnosed as having MAS, presented irregular menstrual cycles (30-180...
Our purpose is to investigate the feasibility of imaging tumor metabolism in breast cancer patients using 13C magnetic resonance spectroscopic (MRSI) hyperpolarized label exchange between injected [1-13C]pyruvate and endogenous lactate pool. Treatment-naive were recruited: four triple-negative grade 3 cancers; two invasive ductal carcinomas that estrogen progesterone receptor-positive (ER/PR+) HER2/neu-negative (HER2-), one 2 3; ER/PR+ HER2- lobular carcinoma (ILC). Dynamic MRSI was...
Measurement of estradiol is useful in women undergoing ovarian stimulation for vitro fertilization and embryo transfer (IVF-ET). The analytical performance a new two-step assay (ADVIA Centaur) estradiol-6 III from Bayer Diagnostics) was evaluated 41 sera 11 stimulation. results were compared to those obtained with two radioimmunoassays (RIAs; RIA Estradiol Immunotech IM 1663 Beckmann Coulter Coat-A-Count Diagnostic Products Corporation) one chemiluminescent immunoassay (CLIA; ADVIA Centaur...