Frédéric Lioté
A5060186682- Gout, Hyperuricemia, Uric Acid
- Rheumatoid Arthritis Research and Therapies
- Spondyloarthritis Studies and Treatments
- Systemic Lupus Erythematosus Research
- Case Reports on Hematomas
- Inflammasome and immune disorders
- Urticaria and Related Conditions
- Autoimmune and Inflammatory Disorders Research
- Osteoarthritis Treatment and Mechanisms
- Infectious Diseases and Tuberculosis
- Bone health and treatments
- Eosinophilic Disorders and Syndromes
- Musculoskeletal synovial abnormalities and treatments
- Bone and Joint Diseases
- Psoriasis: Treatment and Pathogenesis
- Hematological disorders and diagnostics
- Orthopedic Infections and Treatments
- Chronic Lymphocytic Leukemia Research
- Inflammatory Myopathies and Dermatomyositis
- Pregnancy and Medication Impact
- Osteomyelitis and Bone Disorders Research
- Cell Adhesion Molecules Research
- Monoclonal and Polyclonal Antibodies Research
- Lymphoma Diagnosis and Treatment
- Inflammatory mediators and NSAID effects
Université Paris Cité
2016-2025
Assistance Publique – Hôpitaux de Paris
2016-2025
Inserm
2016-2025
Hôpital Lariboisière
2016-2025
Bioscar
2014-2024
Hôpital Paris Saint-Joseph
2024
Sorbonne Paris Cité
2012-2023
Hôpital Saint Joseph
2023
Hôpital Fernand-Widal
1993-2022
University of Auckland
2022
Guidelines and recommendations
Guidelines and recommendations developed and/or endorsed by the American College of Rheumatology (ACR) are intended to provide guidance for particular patterns practice not dictate care a patient.The ACR considers adherence these guidelines be voluntary, with ultimate determination regarding their application made physician in light each patient's individual circumstances.Guidelines promote beneficial or desirable outcomes but cannot guarantee any specific outcome.Guidelines subject periodic...
Rheumatoid arthritis (RA), the most common autoimmune disease, is associated in families with other diseases, including insulin-dependent diabetes mellitus (IDDM). Its genetic component has been suggested by familial aggregation (λs = 5), twin studies, and segregation analysis. HLA , which only susceptibility locus known, estimated to account for one-third of this component. The aim paper was identify new RA loci. A genome scan performed 114 European Caucasian sib pairs from 97 nuclear...
Although gout is the most common inflammatory arthritis, it still frequently misdiagnosed. New data on imaging and clinical diagnosis have become available since first EULAR recommendations for of in 2006. This prompted a systematic review update 2006 recommendations. A literature concerning all aspects was performed. Recommendations were formulated using Delphi consensus approach. Eight key generated. search crystals synovial fluid or tophus aspirates recommended every person with suspected...
Basic calcium phosphate (BCP) crystals are associated with severe osteoarthritis and acute periarticular inflammation. Three main forms of BCP have been identified from pathological tissues: octacalcium phosphate, carbonate-substituted apatite, hydroxyapatite. We investigated the proinflammatory effects these in vitro special regard to involvement NLRP3-inflammasome THP-1 cells, primary human monocytes macrophages, mouse bone marrow-derived macrophages (BMDM). cells stimulated produced IL-1β...
Apremilast, an oral phosphodiesterase 4 inhibitor, downregulates intracellular inflammatory mediator synthesis by elevating cyclic adenosine monophosphate levels. The PALACE 2 trial evaluated apremilast efficacy and safety in patients with active psoriatic arthritis (PsA) despite prior conventional disease-modifying antirheumatic drugs and/or biologic therapy.Eligible were randomized (1:1:1) to placebo, 20 mg BID, or 30 BID. At Week 16, swollen tender joint count improvement < 20% entered...
One-third of patients with rheumatoid arthritis show inadequate response to tumor necrosis factor α (TNF-α) inhibitors; little guidance on choosing the next treatment exists.To compare efficacy a non-TNF-targeted biologic (non-TNF) vs second anti-TNF drug for insufficient TNF inhibitor.A total 300 (conducted between 2009-2012) arthritis, persistent disease activity (disease score in 28 joints-erythrocyte sedimentation rate [DAS28-ESR] ≥ 3.2 [range, 0-9.3]) and an therapy were included...
Objective Calcium pyrophosphate deposition (CPPD) disease is prevalent and has diverse presentations, but there are no validated classification criteria for this symptomatic arthritis. The American College of Rheumatology (ACR) EULAR have developed the first‐ever CPPD disease. Methods Supported by ACR EULAR, a multinational group investigators followed established methodology to develop these criteria. generated lists candidate items refined their definitions, collected de‐identified patient...
Untreated gout is characterised by monosodium urate (MSU) crystal accumulation responsible for recurrent flares that are commonly separated asymptomatic phases. Both phases inflammatory conditions of variable intensity. Gout self-limited reactions involving multiple mediators. This study aimed to characterise the profiles at different
Abbreviations used in this article: ATS, American Thoracic Society; CDC, Centers for Disease Control and Prevention; CT, computed tomography; HIV, human immunodeficiency virus; MRI, magnetic resonance imaging; PPD, purified protein derivative; SPD, spondylodiscitis; SPwD, spondylitis without disk involvement; TB, tuberculosis; Tc, technetium.
Hydroxychloroquine (HCQ) is an important medication for treating systemic lupus erythematosus (SLE). Its blood concentration ([HCQ]) varies widely between patients and a marker predictor of SLE flares. This prospective randomised, double-blind, placebo-controlled, multicentre study sought to compare standard adjusted HCQ dosing schedules that target [HCQ] ≥1000 ng/ml reduce was measured in 573 with (stable disease SELENA-SLEDAI≤12) treated at least 6 months. Patients from 100 750 were...
Objective Blood concentrations of hydroxychloroquine (HCQ) vary widely among patients with systemic lupus erythematosus (SLE). A pharmacokinetic/pharmacodynamic relationship has been found in different situations, and a very low blood concentration HCQ is simple marker nonadherence to treatment. Therefore, interest measurement increased, but little known about factors that influence variability. This study was undertaken analyze determinants concentrations. Methods We conducted retrospective...
Macrophage activation by monosodium urate (MSU) and calcium pyrophosphate (CPP) crystals mediates an interleukin (IL)-1β-dependent inflammation during gout pseudo-gout flare, respectively. Since metabolic reprogramming of macrophages goes along with inflammatory responses dependently on stimuli tissue environment, we aimed to decipher the role glycolysis oxidative phosphorylation in IL-1β-induced microcrystal response.Briefly, vitro study (metabolomics real-time extracellular flux analysis)...
Objective. To determine the prevalence and characterize inflammatory musculoskeletal symptoms of hidradenitis suppurativa (HS), a chronic disease skin appendages. Methods. Patients with HS referred to 3 dermatology university hospital centers were systematically screened for peripheral arthritis, dactylitis, back pain, or enthesitis. After careful clinical examination, patients further classified according imaging criteria spondyloarthritis (SpA) using Amor, European Spondyloarthropathy...
Abstract Introduction Gout is a common arthritis that occurs particularly in patients who frequently have associated comorbidities limit the use of conventional therapies. The main mechanism crystal-induced inflammation interleukin-1 production by activation inflammasome. We aimed to evaluate efficacy and tolerance anakinra gouty patients. Methods conducted multicenter retrospective review receiving for arthritis. reviewed response treatment, adverse events relapses. Results examined data 40...
<h3>Objective</h3> There is a lack of standardisation in the terminology used to describe gout. The aim this project was develop consensus statement describing recommended nomenclature for disease states <h3>Methods</h3> A content analysis gout-related articles from rheumatology and general internal medicine journals published over 5-year period identified potential labels commonly assigned them. Based on these findings, experts gout were invited participate Delphi exercise face-to-face...