A5002438198- Mass Spectrometry Techniques and Applications
- Metabolomics and Mass Spectrometry Studies
- Analytical Chemistry and Chromatography
- Infant Nutrition and Health
- Air Quality and Health Impacts
- Indoor Air Quality and Microbial Exposure
- Atmospheric chemistry and aerosols
- Glycosylation and Glycoproteins Research
- Immune Response and Inflammation
- Antimicrobial Peptides and Activities
- Advanced Chemical Sensor Technologies
- Immunotherapy and Immune Responses
- Liver Disease Diagnosis and Treatment
- Metabolism and Genetic Disorders
- Inflammasome and immune disorders
- Breastfeeding Practices and Influences
- Gout, Hyperuricemia, Uric Acid
Université Paris-Saclay
2023
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2023
Unité de Technologies Chimiques et Biologiques pour la Santé
2023
Technologies pour la Santé
2023
CEA Paris-Saclay
2023
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2023
Institut Parisien de Chimie Moléculaire
2020-2022
Sorbonne Université
2020-2022
Centre National de la Recherche Scientifique
2020
University of Cambridge
2018
Macrophage activation by monosodium urate (MSU) and calcium pyrophosphate (CPP) crystals mediates an interleukin (IL)-1β-dependent inflammation during gout pseudo-gout flare, respectively. Since metabolic reprogramming of macrophages goes along with inflammatory responses dependently on stimuli tissue environment, we aimed to decipher the role glycolysis oxidative phosphorylation in IL-1β-induced microcrystal response.Briefly, vitro study (metabolomics real-time extracellular flux analysis)...
Abstract. Peroxy acids were recently found to be involved in new particle formation the atmosphere and could also substantially contribute towards toxicity. However, a lack of suitable analytical methods for detection characterisation peroxy phase is currently hindering quantitative investigation their contribution these important atmospheric processes. Further development appropriate techniques relevant standards therefore urgently needed. In this study, we synthesised three peroxypinic...
Oligosaccharides have multiple functions essential for health. Derived from the condensation of two to several monosaccharides, they are structurally diverse with many co-occurring structural isomer families, which make their characterization difficult. Thanks its ability separate small molecules based on mass, size, shape, and charge, ion mobility-mass spectrometry (IM-MS) has emerged as a powerful tool separating glycan isomers. Here, potential such technique rapid main human milk...
Rationale Isomer metabolites are involved in metabolic pathways, and their characterization is essential but remains challenging even using high‐performance analytical platforms. The addition of ion mobility prior to mass analysis can help separate isomers. Here, the ability a recently developed trapped spectrometry system metabolite isomers was examined. Methods Three pairs estrogen were studied as model isomeric under both negative positive electrospray ionization (ESI) modes commercial...
Dendritic cells (DCs) are essential immune for defense against external pathogens. Upon activation, DCs undergo profound metabolic alterations whose precise nature remains poorly studied at a large scale and is thus far from being fully understood. The goal of the present work was to develop reliable accurate untargeted metabolomics workflow get deeper insight into metabolism when exposed an infectious agent (lipopolysaccharide, LPS, used mimic bacterial infection). As transition rapidly...
Abstract. Peroxy acids might contribute significantly to particle toxicity and were recently found be involved in new formation the atmosphere. However, a lack of suitable analytical methods for detection characterization peroxy phase is currently hindering quantitative investigation their contribution these important atmospheric processes. Further development appropriate techniques relevant standards therefore urgently needed. In this study, we synthesized three peroxypinic acids, developed...