A5091272930- Mass Spectrometry Techniques and Applications
- Metabolomics and Mass Spectrometry Studies
- Analytical Chemistry and Chromatography
- Polyoxometalates: Synthesis and Applications
- Ion-surface interactions and analysis
- Advanced Proteomics Techniques and Applications
- Conducting polymers and applications
- DNA and Nucleic Acid Chemistry
- Isotope Analysis in Ecology
- Porphyrin and Phthalocyanine Chemistry
- Advanced Chemical Sensor Technologies
- Photodynamic Therapy Research Studies
- Lysosomal Storage Disorders Research
- Metal-Organic Frameworks: Synthesis and Applications
- Infant Nutrition and Health
- Protein Structure and Dynamics
- Sulfur-Based Synthesis Techniques
- Analytical chemistry methods development
- Identification and Quantification in Food
- Hemoglobin structure and function
- Pesticide Residue Analysis and Safety
- Spectroscopy and Chemometric Analyses
- Advanced biosensing and bioanalysis techniques
- Molecular Sensors and Ion Detection
- RNA Interference and Gene Delivery
Institut Parisien de Chimie Moléculaire
2014-2024
Sorbonne Université
2014-2024
Centre National de la Recherche Scientifique
2009-2024
Sorbonne Paris Cité
2016-2024
Laboratoire de Chimie Organique
2006-2024
Institut de Biologie et Technologies
2008-2022
CEA Paris-Saclay
2008-2022
Technologies pour la Santé
2022
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2008-2022
Délégation Paris 6
2021
Clickety click: Click dendrimers, including the first click metallodendrimers, are synthesized in presence of a stoichiometric amount copper(I). The 1,2,3-triazolylferrocenyl dendrimers (see picture) selective electrochemical sensors for both transition-metal cations and oxo anions.
Keggin and Dawson-type polyoxometalates (POMs) covalently grafted to heteroleptic cyclometalated iridium(III) complexes (POM–[Ir] dyads) have been prepared by postfunctionalization of organosilyl organotin POM derivatives. Electronic properties these 4 photosensitized POM–[Ir] dyads were evaluated electrochemical measurements theoretical calculations. These studies reveal that the electron acceptor character POMs vary with structural class (Keggin vs. Dawson) chemical anchorage (organosilyl...
We report the direct introduction of biological samples into a high-resolution mass spectrometer, LTQ-Orbitrap, as fast tool for metabolomic studies. A proof concept study was performed on yeast cell extracts that were introduced spectrometer by using flow injection analysis, with an acquisition time 3 min. Typical spectra contained few thousand m/z signals, 400 which found to be analytically relevant (i.e., their intensity 3-fold higher than background noise and they occurred in at least...
A series of redox tunable polyoxometalate–bodipy conjugates display variable charge transfer dynamics occuring down to 54 ps.
Reproducibility among different types of excitation modes is a major bottleneck in the field tandem mass spectrometry library development metabolomics. In this study, we specifically evaluated influence collision voltage and activation time parameters on spectra for various [collision-induced dissociation (CID), pulsed Q (PQD) higher-energy (HCD)] Orbitrap-based instruments. For purpose, internal energy deposition was probed using an approach based Rice–Rampserger–Kassel–Marcus modeling with...
A 2D supramolecular honeycomb network built on hydrogen bonding of perylene-3,4,9,10-tetracarboxylic acid diimide (PTCDI) and 1,3,5-triazine-2,4,6-triamine (Melamine) has been self-assembled Au(111) by a solution processed method. The ability the porous to host functional molecular oxides or polyoxometalates (POMs) investigated using functionalized species [PW11O39Ge{p-C6H4-C≡C–C6H4-NHC(O) (CH2)4{-CH(CH2)2S-S-}}]4– (KWGe[S-S]): this inorganic/organic hybrid Keggin-type POM core an organic...
Abstract The optical and electrochemical properties of a series polyoxometalate (POM) oxoclusters decorated with two bodipy (boron‐dipyrromethene) light‐harvesting units were examined. Evaluated here in this polyanionic donor‐acceptor system is the effect solvent associated counterions on intramolecular photoinduced electron transfer. results show that both solvents have major impact upon energy charge‐transfer state by modifying solvation shell around POMs. This modification leads to...
Storage of electricity produced intermittently by renewable energy sources is a societal issue. Besides the use batteries and supercapacitors, conversion excess into chemical also actively investigated. The CO 2 to fuel or precursors an option that requires catalyst overcome high activation barrier. Of molecular catalysts, metal complexes with polypyridyl ligands are well represented, among which [Cp*Rh(bpy)Cl] + [M(bpy)(CO) 3 X] (M = Re, Mn) complexes. As redox non‐innocent ligand,...
In current living matter, biopolymers follow specific sequences that give them special properties, such as the sequence of amino acids (AAs) in proteins and peptides. A major challenge for elucidation origins life lies understanding how, example, nonrandom polypeptides have been selected among all possible ones. While many investigations established plausible prebiotic polymerization pathways, surprisingly, only a few attempted to study selectivity these processes. We studied mineral surface...
Immobilization of polyoxometalates (POMs) onto oxides is relevant to many applications in the fields catalysis, energy conversion/storage, or molecular electronics. Optimization and understanding molecule/oxide interface crucial rationally improve performance final materials. We herein describe synthesis covalent grafting POM hybrids with remote carboxylic acid functions flat Si/SiO2 substrates. Special attention has been paid characterization layer description anchoring mode at oxide...
Abstract Introduction Accuracy of feature annotation and metabolite identification in biological samples is a key element metabolomics research. However, the process often hampered by lack spectral reference data experimental conditions, as well logistical difficulties management exchange annotations between laboratories. Objectives To design an open-source infrastructure allowing hosting both nuclear magnetic resonance (NMR) mass spectra (MS), with ergonomic Web interface services to...
We report the detection of nanoparticles formed by irradiating matrix-assisted laser desorption/ionization (MALDI) matrix samples. This is direct evidence for ejection large size aggregates in MALDI process. Nanometer-size particles were generated via a tunable solid-state UV laser, sample placed nitrogen atmosphere. Size distribution measurements performed using differential mobility analyzer and condensation particle counter. Particles 10-1000 nm range detected. The dependence on fluence,...
The charge state distribution of proteins was studied as a function experimental conditions, to improve the understanding matrix-assisted laser desorption/ionization (MALDI) mechanisms. relative abundances multiply-charged ions appear be matrix chosen, fluence and matrix-to-analyte molar ratio. A correlation is found between proton affinity yield singly- versus ions. These results are in good agreement with model which gas-phase intracluster reactions play significant role analyte ion...
Matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-MS) of noncovalent protein complexes is difficult, due to the disruptive nature processes occurring during MALDI sample preparation and ion formation. Sometimes observation intact with only possible if data are acquired from first shot fired at a fresh sample; this called 'first phenomenon'. To study origin phenomenon, we used MALDI-MS confocal scanning microscopy (CLSM) examine typical preparations embedded complexes,...
Handy POMs: Several palladium-catalyzed coupling reactions have been applied to polyoxometalate post-functionalization. The feasibility of each reaction with one model substrate was investigated and set synthetic conditions optimized obtain full conversions high purity hybrid compounds.