A5008207671- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Vasculitis and related conditions
- Lymphoma Diagnosis and Treatment
- Sarcoidosis and Beryllium Toxicity Research
- Chronic Lymphocytic Leukemia Research
- Hepatitis C virus research
- Gout, Hyperuricemia, Uric Acid
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Autoimmune and Inflammatory Disorders Research
- Monoclonal and Polyclonal Antibodies Research
- Urticaria and Related Conditions
- Spondyloarthritis Studies and Treatments
- Systemic Sclerosis and Related Diseases
- Bone health and osteoporosis research
- Case Reports on Hematomas
- Liver Disease Diagnosis and Treatment
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Musculoskeletal synovial abnormalities and treatments
- Bone and Joint Diseases
- Drug-Induced Adverse Reactions
- Renal Diseases and Glomerulopathies
- Cell Adhesion Molecules Research
- Eosinophilic Disorders and Syndromes
Georgetown University
2016-2025
Howard University
2016-2025
Howard University Hospital
2012-2024
Washington DC VA Medical Center
2013-2024
Fairfield Medical Center
2023
University of North Carolina Health Care
2023
Ohio University
2023
American College of Rheumatology
2023
St. Luke's Hospital
2020
Georgetown-Howard Universities Center for Clinical and Translational Science
2015-2019
Objective: To prospectively study the clinical features, pathophysiology, treatment, and prognosis of Wegener granulomatosis. Design: Of 180 patients with granulomatosis referred to National Institute Allergy Infectious Diseases during past 24 years, 158 have been followed for 6 months years (a total 1229 patient-years). Measurements: Characteristics presentation, surgical pathology, course illness, laboratory radiographic findings, results medical treatment recorded in a computer-based...
To evaluate prospectively the clinical features, angiographic findings, and response to treatment of patients with Takayasu arteritis.60 arteritis were studied at National Institute Allergy Infectious Diseases between 1970 1990 followed for 6 months 20 years (median follow-up, 5.3 years).Data on laboratory disease course, therapy all recorded stored in a computer-based retrieval system.The Warren Magnuson Clinical Center Institutes Health.In our series patients, was more common Asian persons...
Guidelines and recommendations
Guidelines and recommendations developed and/or endorsed by the American College of Rheumatology (ACR) are intended to provide guidance for particular patterns practice not dictate care a patient.The ACR considers adherence these guidelines be voluntary, with ultimate determination regarding their application made physician in light each patient's individual circumstances.Guidelines promote beneficial or desirable outcomes but cannot guarantee any specific outcome.Guidelines subject periodic...
Abstract Objective . To identify the role of methotrexate (MTX) in treatment persistent or recurrent Takayasu arteritis that is refractory to with glucocorticoids (GC) alone. Methods An open‐label pilot study weekly low‐dose MTX + GC was performed. Outcome evaluated according clinical characteristics, laboratory abnormalities, findings on routinely performed angiographic studies, and ability withdraw therapy. Eighteen patients entered study; 2 dropped out, 16 were followed up for a mean...
To examine the degree to which shared risk factors explain relationship of periodontitis (PD) rheumatoid arthritis (RA) and determine associations PD Porphyromonas gingivalis with pathologic clinical features RA.Patients RA (n = 287) patients osteoarthritis as disease controls 330) underwent a standardized periodontal examination. The HLA-DRB1 status all participants was imputed using single-nucleotide polymorphisms from extended major histocompatibility complex. Circulating anti-P...
Background: Similarities exist in the epidemiology and immunopathogenesis of periodontitis rheumatoid arthritis (RA), but associations between their respective disease activities severities are less well documented. We evaluated prevalence severity United States (U.S.) veterans with RA relationship to activity severity. Methods: Patients from an outpatient rheumatology clinic were eligible, patients osteoarthritis (OA) served as controls. Dentists, masked rheumatologic diagnoses, performed...
The co-occurrence of rheumatoid factor (RF) and anti-citrullinated protein antibody (ACPA) positivity in arthritis (RA) is well described. However, the mechanisms underlying potential interaction between these 2 distinct autoantibodies have not been defined. aim this study was to evaluate epidemiologic molecular ACPAs RF its association with both disease activity measures RA-associated inflammation.In a cohort 1,488 US veterans RA, serum levels cytokines multiplex were compared following...
To assess the correlation and prognostic value of antineutrophil cytoplasmic antibody (cANCA) titers with disease activity in patients Wegener's granulomatosis (WG).One hundred six WG had serum ANCA determinations; 72 serial obtained routinely at 1-3-month intervals. One twelve subjects (19 whom were healthy donors) served as controls. All samples tested for cANCA by an indirect immunofluorescence technique. A prospective analysis values was performed. Disease assessed according to clinical,...
Abstract Objective . To determine the efficacy of low‐dose methotrexate (MTX) plus prednisone in treatment Wegener's granulomatosis (WG). Methods An open‐label study weekly MTX for WG was performed. Forty‐two patients who did not have immediately life‐threatening disease were enrolled into study. Outcome determined by clinical characteristics and pathologic, laboratory, radiographic findings. Results Weekly administration resulted remission 30 42 (71%). The median time to 4.2 months....
Abstract Objective . To identify alternatives to daily low‐dose cyclophosphamide (CYC) in the treatment of Wegener's granulomatosis (WG). Methods An open‐label pilot study weekly methotrexate (MTX) plus glucocorticoids (GC) for patients with WG was performed. Twenty‐nine who did not have immediately life‐threatening disease were included. Outcome determined by clinical characteristics, pathologic findings, course illness, laboratory and radiographic successful withdrawal GC therapy. Results...
Abstract Wegener's granulomatosis (WG) is a multisystem inflammatory disease characterized by vasculitis, granuloma formation, and necrosis. Among 158 patients treated at the National Institutes of Health during past 24 years, 145 (92%) had an otolaryngologic manifestation their 25 (16%) subglottic stenosis (SGS). SGS varied from asymptomatic to life‐threatening. Sixteen (80%) 20 with fixed required surgical intervention, including manual dilations, carbon‐dioxide laser resections,...
Objective. 25-hydroxy-vitamin D (25-OH-D) insufficiency/deficiency is increasingly prevalent and has been associated with many chronic diseases, including rheumatoid arthritis (RA). Our purpose was to define the prevalence associations of 25-OH-D in a cohort US veterans RA. Methods. Vitamin status assessed patients RA using radioimmunoassay on banked plasma collected at enrollment. Insufficiency defined as concentrations < 30 ng/ml deficiency 20 ng/ml. Associations patient characteristics...
There has been limited investigation into cause-specific mortality and the associated risk factors in men with rheumatoid arthritis (RA). We investigated all-cause RA, examining determinants of survival.Men from a longitudinal RA registry were followed enrollment until death or through 2013. Vital status cause determined using National Death Index. Crude rates standardized ratios (SMRs) calculated for all-cause, cardiovascular disease (CVD), cancer, respiratory mortality. Associations...
Abstract Objectives To determine whether RA and interstitial lung disease (ILD) severity measures are associated with survival in patients RA-ILD. Methods We studied US veterans RA-ILD participating a multicentre, prospective cohort study. activity (28-joint DAS [DAS28-ESR]) functional status (multidimensional HAQ [MDHAQ]) were collected longitudinally while pulmonary function tests (forced vital capacity [FVC], diffusing for carbon monoxide) obtained from medical records. Vital cause of...
Objective To evaluate the associations of plasma matrix metalloproteinases (MMPs) with prevalent and incident interstitial lung disease (ILD) in people rheumatoid arthritis (RA). Methods Within a multicenter, prospective cohort US veterans RA, we performed cross‐sectional study ILD ILD. diagnoses were validated by medical record review provider chest imaging and/or pathology reports. MMP‐1, 3, 7, 9 concentrations measured samples, then standardized categorized into quartiles. The MMPs...
The risk factors and clinical laboratory parameters in Pneumocystis carinii pneumonia patients with Wegener's granulomatosis have not been well characterized. We undertook a retrospective chart review of all diagnosis P. who were followed at the National Institute Allergy Infectious Diseases Institutes Health. focused on clinical, laboratory, roentgenologic evidence pneumonia. Eleven cases diagnosed some 180 granulomatosis, for an overall incidence approximately 6%. All developed either...
<h3>Objective</h3> To examine associations of anti-cyclic citrullinated peptide (aCCP) antibody and rheumatoid factor (RF) concentrations with future disease activity in men arthritis (RA). <h3>Methods</h3> Outcome measures were examined male US veterans RA included (1) proportion observations remission (disease score (DAS28) ≤2.6); (2) for ≥3 consecutive months; (3) area under the curve (AUC) DAS28. The autoantibody concentration (per 100 unit increments) outcomes using multivariate...
Objectives. To examine the all-cause mortality rate and factors associated with in US veteran men RA. Methods. Men RA were enrolled followed until death or censoring. Vital status was ascertained through systematic record review standardized ratios (SMRs) calculated using life tables for men. Multivariate Cox proportional hazards regression used to independent associations of patient including socio-demographics, comorbidity, measures disease activity/severity medication use mortality....
The Veterans Affairs (VA) Rheumatoid Arthritis (VARA) registry and the VA Pharmacy Benefits Management database were linked to determine association of methotrexate (MTX) adherence with rheumatoid arthritis (RA) disease activity.For each patient, medication possession ratio (MPR) was calculated for first episode MTX exposure a duration ≥12 weeks both new established users. High defined as an MPR ≥0.80 low <0.80. For mean Disease Activity Score 28 joints (DAS28) score, erythrocyte...