A5048537082- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Bone and Joint Diseases
- Systemic Sclerosis and Related Diseases
- Nutrition and Health in Aging
- Hepatitis C virus research
- Spondyloarthritis Studies and Treatments
- Osteoarthritis Treatment and Mechanisms
- Lymphoma Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Biosimilars and Bioanalytical Methods
- Chronic Lymphocytic Leukemia Research
- Gout, Hyperuricemia, Uric Acid
- Body Composition Measurement Techniques
- Sarcoidosis and Beryllium Toxicity Research
- Frailty in Older Adults
- Bone health and osteoporosis research
- Adipokines, Inflammation, and Metabolic Diseases
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Viral Infections and Immunology Research
- Inflammatory Myopathies and Dermatomyositis
- Total Knee Arthroplasty Outcomes
- Health Systems, Economic Evaluations, Quality of Life
University of Pennsylvania
2016-2025
Philadelphia VA Medical Center
2016-2025
Royal Perth Hospital
2025
Lurie Children's Hospital
2023-2024
Hospital of the University of Pennsylvania
2009-2024
American College of Rheumatology
2016-2024
Wright State University
2024
Durham VA Medical Center
2021-2024
University of North Carolina at Chapel Hill
2021-2024
Harvard University
2016-2024
Abstract Objective To determine if hyperuricemia and gouty arthritis are independent risk factors for acute myocardial infarction (MI) and, so, whether they of renal function, diuretic use, metabolic syndrome, other established factors. Methods We performed multivariable logistic instrumental variable probit regressions on data from the Multiple Risk Factor Intervention Trial (MRFIT). Results Overall, there were 12,866 men in MRFIT who followed up a mean 6.5 years. There 118 events MI group...
Across a wide range of tasks, research has shown that people make poor probabilistic predictions future events. Recently, the U.S. Intelligence Community sponsored series forecasting tournaments designed to explore best strategies for generating accurate subjective probability estimates geopolitical In this article, we describe winning strategy: culling off top performers each year and assigning them into elite teams superforecasters. Defying expectations regression toward mean 2 years in...
Objective Rheumatoid arthritis (RA) and its treatments are associated with an increased risk of infection, but it remains unclear whether these factors have impact on the or severity COVID‐19. The present study was undertaken to assess COVID‐19 in a US Department Veterans Affairs (VA) cohort patients RA those without RA. Methods A matched using national VA data conducted. Patients diagnosed as having were identified among nondeceased individuals who active health care system January 1, 2020...
<b><i>Background:</i></b> Poor physical performance and frailty are associated with elevated risks of death disability. Chronic kidney disease (CKD) is also strongly these outcomes. The poor among CKD patients, however, not well established. <b><i>Methods:</i></b> We measured the Short Physical Performance Battery (SPPB; a summary test gait speed, chair raises balance; range 0-12) five elements 1,111 Renal Insufficiency Cohort participants....
Background: Low-dose glucocorticoids are frequently used for the management of rheumatoid arthritis (RA) and other chronic conditions, but safety long-term use remains uncertain. Objective: To quantify risk hospitalized infection with low-dose in patients RA receiving stable disease-modifying antirheumatic drug (DMARD) therapy. Design: Retrospective cohort study. Setting: Medicare claims data Optum's deidentified Clinformatics Data Mart database from 2006 to 2015. Patients: Adults a DMARD...
In contrast to what is observed in the general population, a low body mass index (BMI) has been associated with accelerated mortality patients rheumatoid arthritis (RA). The aim of this study was assess whether weight loss might explain these seemingly paradoxical observations.
Abstract Objectives To determine whether RA and interstitial lung disease (ILD) severity measures are associated with survival in patients RA-ILD. Methods We studied US veterans RA-ILD participating a multicentre, prospective cohort study. activity (28-joint DAS [DAS28-ESR]) functional status (multidimensional HAQ [MDHAQ]) were collected longitudinally while pulmonary function tests (forced vital capacity [FVC], diffusing for carbon monoxide) obtained from medical records. Vital cause of...
Importance Involvement of palliative care specialists in the medical oncology patients has been repeatedly observed to improve patient-reported outcomes, but there is no analogous research surgical populations. Objective To determine whether surgeon–palliative team comanagement, compared with surgeon alone management, improves perioperative outcomes among pursuing curative-intent surgery for high morbidity and mortality upper gastrointestinal (GI) cancers. Design, Setting, Participants From...
Objective To evaluate the associations of plasma matrix metalloproteinases (MMPs) with prevalent and incident interstitial lung disease (ILD) in people rheumatoid arthritis (RA). Methods Within a multicenter, prospective cohort US veterans RA, we performed cross‐sectional study ILD ILD. diagnoses were validated by medical record review provider chest imaging and/or pathology reports. MMP‐1, 3, 7, 9 concentrations measured samples, then standardized categorized into quartiles. The MMPs...
Objective To quantify muscle outcomes, independent of fat mass, in rheumatoid arthritis (RA) patients compared to healthy controls. Methods Quantitative computed tomography scans measured calf and cross‐sectional area (CSA) density (an index intramuscular adipose tissue), isometric dynamometry was used measure ankle strength 50 participants with RA ages 18–70 years 500 Multivariable linear regression models assessed deficits after adjusting for group differences adiposity assessing an...
<h3>Objective</h3> To determine if early MRI measures predict X-ray progression at 1 and 2 years in a large RA trial cohort. <h3>Design</h3> This study included 256 methotrexate (MTX)-naïve patients from randomised placebo-controlled of golimumab (GO-BEFORE). MRIs wrist 2nd–5th metacarpophalangeal joints 0, 12, 24, 52 104 weeks were obtained scored using the RAMRIS system. Multivariable logistic regression examined baseline change (weeks 12/24) scores independently predicted van der...
The C-reactive protein (CRP) level and erythrocyte sedimentation rate (ESR) are important disease activity biomarkers in rheumatoid arthritis (RA). This study aimed to determine what extent obesity biases these biomarkers.Body mass index (BMI) associations with CRP ESR were assessed 2 RA cohorts: the cross-sectional Body Composition (BC) cohort (n = 451), including whole-body dual x-ray absorptiometry measures of fat index; longitudinal Veterans Affairs Rheumatoid Arthritis (VARA) registry...
Objective. The objective of this study was to examine cause-specific mortality in patients with PsA compared the general population and RA. Methods. A cohort performed using Health Improvement Network among aged 18–89 years data from 1994 2010. RA were defined by medical codes, up 10 unexposed controls matched on practice start date within practice. Cause death classified categories UK statistics. Each manually reviewed ensure appropriate classification. Age- sex-adjusted hazard ratios (HRs)...
Objective The optimal timing of tumor necrosis factor antagonists before elective surgery is unknown. This study evaluated the association between infliximab and serious infection after hip or knee arthroplasty. Methods A retrospective cohort US Medicare patients with rheumatoid arthritis, inflammatory bowel disease, psoriasis, psoriatic ankylosing spondylitis who received within 6 months arthroplasty from 2007 to 2013. Propensity‐adjusted analyses examined whether stop (time most recent...
ABSTRACT Allogeneic hematopoietic stem-cell transplantation (alloHSCT) survivors treated with total body irradiation (TBI) exhibit bone deficits and excess adiposity, potentially related to altered mesenchymal stem cell differentiation into osteoblasts or adipocytes. We examined associations among fat distribution, microarchitecture, insulin resistance in alloHSCT after TBI. This was a cross-sectional observational study of 25 (aged 12 years) median 9.7 (4.3 19.3) years compared age-, race-,...
Objective To determine the risk of fracture and osteoporosis among patients with psoriatic arthritis (PsA) psoriasis, compared general population rheumatoid (RA). Methods A population-based cohort study was performed in The Health Improvement Network UK using data from 1994 to 2014. Patients aged 18–89 years PsA or psoriasis up five unexposed controls matched by practice start date within that were included. RA included for comparison. Severe defined a code either phototherapy systemic...