A5049420631- Rheumatoid Arthritis Research and Therapies
- Alcohol Consumption and Health Effects
- Monoclonal and Polyclonal Antibodies Research
- Systemic Lupus Erythematosus Research
- Liver Disease Diagnosis and Treatment
- Atherosclerosis and Cardiovascular Diseases
- Advanced Glycation End Products research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cytomegalovirus and herpesvirus research
- Viral-associated cancers and disorders
- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Diabetes and associated disorders
- Lymphoma Diagnosis and Treatment
- Immune cells in cancer
- Fatty Acid Research and Health
- Eicosanoids and Hypertension Pharmacology
- Adipokines, Inflammation, and Metabolic Diseases
- Air Quality and Health Impacts
- Inhalation and Respiratory Drug Delivery
- Asthma and respiratory diseases
- Cell Adhesion Molecules Research
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Autoimmune and Inflammatory Disorders Research
University of Nebraska Medical Center
2016-2025
VA Nebraska Western Iowa Health Care System
2016-2025
College of Saint Mary
2025
Omaha VA Medical Center
2005-2024
Grace (United States)
2024
University of Pittsburgh
2023
University Health Care System
2023
University of Colorado Health
2023
University of Nebraska at Omaha
1987-2022
University of Nebraska System
2021
To examine the degree to which shared risk factors explain relationship of periodontitis (PD) rheumatoid arthritis (RA) and determine associations PD Porphyromonas gingivalis with pathologic clinical features RA.Patients RA (n = 287) patients osteoarthritis as disease controls 330) underwent a standardized periodontal examination. The HLA-DRB1 status all participants was imputed using single-nucleotide polymorphisms from extended major histocompatibility complex. Circulating anti-P...
Abstract Scavenger receptors constitute a large family of proteins that are structurally diverse and participate in wide range biological functions. These expressed predominantly by myeloid cells recognize variety ligands including endogenous modified host-derived molecules microbial pathogens. There currently eight classes scavenger receptors, many which have multiple names, leading to inconsistencies confusion the literature. To address this problem, workshop was organized United States...
To examine the relationship of Porphyromonas gingivalis to presence autoantibodies in individuals at risk rheumatoid arthritis (RA).Study participants included following: 1) a cohort enriched subjects with HLA-DR4 and 2) RA by virtue having first-degree relative RA. None study satisfied American College Rheumatology 1987 classification criteria for Autoantibodies measured anti-citrullinated protein antibody (ACPA; second-generation anti-cyclic citrullinated peptide enzyme-linked...
The co-occurrence of rheumatoid factor (RF) and anti-citrullinated protein antibody (ACPA) positivity in arthritis (RA) is well described. However, the mechanisms underlying potential interaction between these 2 distinct autoantibodies have not been defined. aim this study was to evaluate epidemiologic molecular ACPAs RF its association with both disease activity measures RA-associated inflammation.In a cohort 1,488 US veterans RA, serum levels cytokines multiplex were compared following...
Objective Rheumatoid arthritis (RA) and its treatments are associated with an increased risk of infection, but it remains unclear whether these factors have impact on the or severity COVID‐19. The present study was undertaken to assess COVID‐19 in a US Department Veterans Affairs (VA) cohort patients RA those without RA. Methods A matched using national VA data conducted. Patients diagnosed as having were identified among nondeceased individuals who active health care system January 1, 2020...
Acetaldehyde and the lipid peroxidation-derived aldehyde malondialdehyde (MDA), are reactive compounds that generated during ethanol metabolism in liver, both aldehydes have been shown to be capable of binding proteins forming stable adducts. Because similar concentrations MDA acetaldehyde can coexist liver oxidation, protein adduct formation presence these was studied under vitro vivo conditions. When were incubated acetaldehyde, caused a marked concentration-dependent increase proteins....
<h3>Background</h3> Rheumatoid arthritis (RA) is characterised by autoimmunity to citrullinated proteins, and there increasing epidemiologic evidence linking <i>Porphyromonas gingivalis</i> RA. <i>P apparently unique among periodontal pathogens in possessing a citrullinating enzyme, peptidylarginine deiminase (PPAD) with the potential generate antigens driving autoimmune response. <h3>Objectives</h3> To examine immune response PPAD patients RA, individuals periodontitis (PD) controls...
BACKGROUND: Rheumatoid arthritis (RA) is a chronic, systemic, inflammatory disease that affects approximately 0.5 to 1 percent of the adults worldwide and commonly results in joint destruction significant impairment quality life. RA considered as an autoimmune with unknown etiology. Many pathogenic pathways have been revealed recently, which led development various novel therapies. OBJECTIVE: The current treatments include 4 categories: non-steroidal anti-inflammatory drugs (NSAIDs),...
Aldehyde dehydrogenase 2 (ALDH2) is the major enzyme that metabolizes acetaldehyde produced from alcohol metabolism. Approximately 40-50% of East Asians carry an inactive ALDH2 gene and exhibit accumulation after consumption. However, role deficiency in pathogenesis alcoholic liver injury remains obscure. In present study, wild-type ALDH2(-/-) mice were subjected to ethanol feeding and/or carbon tetrachloride (CCl4 ) treatment, was assessed. Compared with mice, ethanol-fed had higher levels...
Objective. 25-hydroxy-vitamin D (25-OH-D) insufficiency/deficiency is increasingly prevalent and has been associated with many chronic diseases, including rheumatoid arthritis (RA). Our purpose was to define the prevalence associations of 25-OH-D in a cohort US veterans RA. Methods. Vitamin status assessed patients RA using radioimmunoassay on banked plasma collected at enrollment. Insufficiency defined as concentrations < 30 ng/ml deficiency 20 ng/ml. Associations patient characteristics...
Objective Malondialdehyde‐acetaldehyde (MAA) adducts are a product of oxidative stress associated with tolerance loss in several disease states. This study was undertaken to investigate the presence MAA and circulating anti‐MAA antibodies patients rheumatoid arthritis (RA). Methods Synovial tissue from RA osteoarthritis (OA) were examined for MAA‐modified citrullinated proteins. Anti‐MAA antibody isotypes measured (n = 1,720) healthy controls 80) by enzyme‐linked immunosorbent assay....
Objective To evaluate the associations of plasma matrix metalloproteinases (MMPs) with prevalent and incident interstitial lung disease (ILD) in people rheumatoid arthritis (RA). Methods Within a multicenter, prospective cohort US veterans RA, we performed cross‐sectional study ILD ILD. diagnoses were validated by medical record review provider chest imaging and/or pathology reports. MMP‐1, 3, 7, 9 concentrations measured samples, then standardized categorized into quartiles. The MMPs...
Acetaldehyde and malonildialdehyde can form hybrid protein adducts, named MAA adducts that have strong immunogenic properties. The formation of in the liver chronic alcohol-fed rats is associated with development circulating antibodies specifically recognized these adducts. aim this study was to examine whether might participate immune response human alcohol-induced disease. Circulating against were evaluated 50 patients hepatitis or cirrhosis, 40 non-alcohol-induced disease, 15 heavy...
<h3>Objective</h3> To examine associations of anti-cyclic citrullinated peptide (aCCP) antibody and rheumatoid factor (RF) concentrations with future disease activity in men arthritis (RA). <h3>Methods</h3> Outcome measures were examined male US veterans RA included (1) proportion observations remission (disease score (DAS28) ≤2.6); (2) for ≥3 consecutive months; (3) area under the curve (AUC) DAS28. The autoantibody concentration (per 100 unit increments) outcomes using multivariate...
Objectives. To examine the all-cause mortality rate and factors associated with in US veteran men RA. Methods. Men RA were enrolled followed until death or censoring. Vital status was ascertained through systematic record review standardized ratios (SMRs) calculated using life tables for men. Multivariate Cox proportional hazards regression used to independent associations of patient including socio-demographics, comorbidity, measures disease activity/severity medication use mortality....
Objective To compare serum anti–malondialdehyde–acetaldehyde (anti‐ MAA ) antibody levels and expression in lung tissue from patients with rheumatoid arthritis–associated interstitial disease (RA‐ILD) to those found controls. Methods Anti‐ (IgA, IgM, IgG) concentrations were measured RA‐ILD compared of RA chronic obstructive pulmonary ( COPD without disease. Associations between anti‐ assessed using multivariable logistic regression. Lung , other ILD or emphysema, controls (n = 3 per group)...
Objectives. Cigarette smoking is a major risk factor for RA and has been associated with increased disease severity lower rates of remission. We hypothesized that inflammation activity would be status this related to levels ACPA. Methods. patients from the Veterans Affairs registry were studied (n = 1466): 76.9% anti-CCP2 positive, 89% male, median age 63 years (interquartile range 57–72), duration 8.45 2.8–18). Baseline serum samples evaluated anti-CCP2, RF, 19 distinct ACPAs 17 cytokines....