A5101635192- Legume Nitrogen Fixing Symbiosis
- Plant Pathogenic Bacteria Studies
- Global Cancer Incidence and Screening
- Lipid Membrane Structure and Behavior
- Carbohydrate Chemistry and Synthesis
- Polysaccharides and Plant Cell Walls
- Advances in Oncology and Radiotherapy
- Proteoglycans and glycosaminoglycans research
- Bacteriophages and microbial interactions
- Bacterial Genetics and Biotechnology
- Soil erosion and sediment transport
- MicroRNA in disease regulation
- Inflammatory mediators and NSAID effects
- Antibiotic Resistance in Bacteria
- BRCA gene mutations in cancer
- Eicosanoids and Hypertension Pharmacology
- Craniofacial Disorders and Treatments
- Congenital Anomalies and Fetal Surgery
- Health Sciences Research and Education
- Lysosomal Storage Disorders Research
- Extracellular vesicles in disease
- Polysaccharides Composition and Applications
- Biomedical and Engineering Education
- Glycosylation and Glycoproteins Research
- Hydrology and Sediment Transport Processes
Atlantic Cancer Research Institute
2024
Royal Manchester Children's Hospital
2021
Manchester University
2021
King's College London
2011-2013
Norwegian University of Science and Technology
2005
Newcastle University
2003-2005
Reckitt Benckiser (United Kingdom)
2003
University of Hull
1993-1998
University of California, Santa Barbara
1996
A unique flume that measures the erosion of sediments at high shear stresses and with sediment depth has been designed, constructed, used. Experiments in this flume, Sedflume, can be done either reconstructed or relatively undisturbed from field. With kind sediment, two different types experiments conducted. The first type determines critical stress for as a function depth, while second rate both depth. Measurements rates Trenton Channel Detroit River Michigan Lower Fox Fiver Wisconsin were...
Extracellular vesicles (EVs) are gaining interest as efficient, biocompatible vehicles for cellular delivery of therapeutic cargo. Precipitation-based methods the isolation EVs remain popular due to ease use and lack requirements specialized equipment. We describe here a novel charge-based EV method that is simple, scalable, uses inexpensive polyethylenimine (PEI) polymers. GFP-expressing were isolated from conditioned cell culture (CCM) media HEK293-GFP cells using either branched 10 kDa...
The gel nature of mucus is fundamental to its physiological functions; however, the structure matrix unclear. Here, small and large deformation rheology has been used investigate physical forces that maintain this in pig gastric mucus. gelation process shown be comparable with other polymer systems. Nongelling portions mucin have identified within network, importance transient, relaxable interactions maintenance demonstrated. considered relation functional properties gels.
Burkholderia cepacia produces an unusual range of polar lipids, which includes two forms each phosphatidylethanolamine (PE) and ornithine amide lipid (OL), differing in the presence or absence 2-hydroxy fatty acids. By using chemostat cultures chemically defined media, variations content proportions individual lipids have been studied as a function (a) growth temperature, (b) rate (c) growth-limiting nutrient (carbon, magnesium, phosphorus oxygen). Total cellular carbon-limited was lowest at...
Mucous secretions have a wide range of biological functions that are intimately linked with their rheological properties. In addition, many mucous exposed to significant stress and deformation during physiological function. This study has examined the response three systems, native pig gastric mucus, purified mucin gels, alginate increasing applied level sufficient induce flow behavior. A novel, frequency-dependent hardening was observed in all systems. behavior may play role ability systems...
Like several other strains of Burkholderia (Pseudomonas) cepacia, the reference strain for serogroup O4 in French typing scheme [Heidt, A., Monteil, H. & Richard, C. (1983) J. Clin. Microbiol. 18, 738-740] produces a lipopolysaccharide containing two distinct polymers. Attempts to separate polymers chromatographically were unsuccessful, but periodate-resistant major polymer could be isolated by application Smith degradation technique mixture. By means chemical and NMR spectroscopic analysis,...
The O9 antigen of Burkholderia (Pseudomonas) cepacia has the following disaccharide repeating-unit: → 4)-α-D-Glc-p-(1 3)-α-L-Rha p-(1 same unit is present in O antigens Serratia marcescens strain S1254 and serogroup O4 (predominantly acetylated at O-2 rhamnose latter case).
The synthetic prostaglandin endoperoxide analogues 15-hydroxy-9,11-(epoxymethano)prosta-5,13-dien-1-oic acid (EPA-I) and 15-hydroxy-11,9-(epoxymethano)prosta-5,13-dien-1-oic (EPA-II) inhibited ADH-induced water flow in the isolated urinary bladder of toad. In certain other biologic systems, EPA-I appeared to possess "thromboxane-like" activity. Thromboxanes, therefore, as well classical E prostaglandins may be modulators ADH response. To further characterize effect on ADH, interaction...
Reference strains of ‘Pseudomonas diazotrophicus’ produce a range polar lipids atypical authentic Pseudomonas species. In addition to the phospholipids common in Gram-negative bacteria (phosphatidylglycerol, diphosphatidylglycerol, and phosphatidylethanolamine), N-methylated derivatives phosphatidylethanolamine (including phosphatidylcholine) an ornithine amide lipid are also present. The preponderant ester-bound fatty acid (up 80% total) is cis-vaccenic (cis-octadec-11-enoic acid), while...
This study explored the secondary school transition experiences of children with cleft lip and/or palate (CL/P). Data were collected via semi-structured interviews and analysed using interpretative phenomenological analysis (IPA). Participants recruited from a National Health Service (NHS) specialist service covering large geographical area in United Kingdom. Six participants CL/P (aged 11–12 years old) their first 12 months following to interviewed. Four themes describe participants’...