Thomas S. Hayday
A5090201792- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- COVID-19 and healthcare impacts
- Cancer Immunotherapy and Biomarkers
- Vaccine Coverage and Hesitancy
- interferon and immune responses
- CAR-T cell therapy research
- Immune responses and vaccinations
- Inflammasome and immune disorders
- Long-Term Effects of COVID-19
- Phagocytosis and Immune Regulation
- Hematopoietic Stem Cell Transplantation
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cholesterol and Lipid Metabolism
- Endoplasmic Reticulum Stress and Disease
- Asthma and respiratory diseases
- RNA Interference and Gene Delivery
- Allergic Rhinitis and Sensitization
- Trace Elements in Health
- Skin and Cellular Biology Research
- Hereditary Neurological Disorders
- IL-33, ST2, and ILC Pathways
King's College London
2012-2023
Improved understanding and management of COVID-19, a potentially life-threatening disease, could greatly reduce the threat posed by its etiologic agent, SARS-CoV-2. Toward this end, we have identified core peripheral blood immune signature across 63 hospital-treated patients with COVID-19 who were otherwise highly heterogeneous. The includes discrete changes in B myelomonocytic cell composition, profoundly altered T phenotypes, selective cytokine/chemokine upregulation SARS-CoV-2-specific...
The efficacy and safety profiles of vaccines against SARS-CoV-2 in patients with cancer is unknown. We aimed to assess the immunogenicity BNT162b2 (Pfizer-BioNTech) vaccine cancer.
ABSTRACT Background The efficacy and safety profile of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have not been definitively established in immunocompromised patient populations. Patients with a known cancer diagnosis were hitherto excluded from trials the currently clinical use. Methods This study presents data on immune BNT162b2 (Pfizer-BioNTech) vaccine 54 healthy controls 151 mostly elderly patients solid haematological malignancies, respectively,...
A Correction to this paper has been published: https://doi.org/10.1038/s41591-020-01186-5
Abstract Regulatory B cells restrict immune and inflammatory responses across a number of contexts. This capacity is mediated primarily through the production IL-10. Here we demonstrate that induction regulatory program in human dependent on metabolic priming event driven by cholesterol metabolism. Synthesis intermediate geranylgeranyl pyrophosphate (GGPP) required to specifically drive IL-10 production, attenuate Th1 responses. Furthermore, GGPP-dependent protein modifications control...
Abstract Person-to-person transmission of SARS-CoV-2 virus has triggered a global emergency because its potential to cause life-threatening Covid-19 disease. By comparison paucisymptomatic clearance by most individuals, been proposed reflect insufficient and/or pathologically exaggerated immune responses. Here we identify consensus peripheral blood signature across 63 hospital-treated patients who were otherwise highly heterogeneous. The core conspicuously blended adaptive B cell responses...
There is an increasing body of evidence suggesting that the transfer preformed MHC class I:peptide complexes between a virus-infected cell and uninfected APC, termed cross-dressing, represents important mechanism Ag presentation to CD8+ T cells in host defense. However, although it has been shown memory can be activated by dendritic (DCs) cross-dressed from parenchymal cells, unknown whether conditions exist during virus infection which naive are primed differentiate cytolytic effectors...
T-cell depletion therapy is used to prevent acute allograft rejection, treat autoimmunity and create space for bone marrow or hematopoietic cell transplantation. The evolved response loss a transient increase in IL-7 that drives compensatory homeostatic proliferation (HP) of mature T cells. Paradoxically, the exaggerated form this process occurs following lymphodepletion expands effector T-cells, often causing immunological tolerance results rapid graft autoimmunity, exacerbated...
SPG23 is an autosomal-recessive neurodegenerative subtype of lower limb spastic paraparesis with additional diffuse skin and hair dyspigmentation at birth followed by further patchy pigment loss during childhood. Previously, genome-wide linkage in Arab-Israeli pedigree mapped the gene to approximately 25 cM locus on chromosome 1q24–q32. By using whole-exome sequencing a Palestinian-Jordanian pedigree, we identified complex homozygous 4-kb deletion/20-bp insertion DSTYK (dual serine-threonine...
Whereas pathogen-specific T and B cells are a primary focus of interest during infectious disease, we have used COVID-19 to ask whether their emergence comes at cost broader cell repertoire disruption. We applied genomic DNA-based approach concurrently study the immunoglobulin-heavy (IGH) receptor (TCR) β δ chain loci 95 individuals. Our detected anticipated focusing for IGH repertoire, including expansions clusters related sequences temporally aligned with SARS-CoV-2–specific...
An amendment to this paper has been published and can be accessed via a link at the top of paper.
Clonotypic αβ T cell responses to cargoes presented by major histocompatibility complex (MHC), MR1, or CD1 proteins underpin adaptive immunity. Those are mostly mediated complementarity-determining region 3 motifs created quasi-random receptor (TCR) gene rearrangements, with diversity being highest for TCRγδ. Nonetheless, TCRγδ also displays nonclonotypic innate responsiveness following engagement of germline-encoded Vγ-specific residues butyrophilin (BTN) BTN-like (BTNL) that uniquely...
Summary Background Emerging pandemics place immense strains on healthcare systems that may be ameliorated by rapid development of biomarkers whose measurements predict disease severity and additionally inform about causation. Conspicuously, such routine measures rarely include immunological cytokines or chemokines, despite their contributions to host protection immunopathology. Methods Multiplex bead-array ELISA-based serum cytokine chemokine measurements, routinely employed clinical...
Summary Regulatory B cells restrict immune and inflammatory responses across a number of contexts. This capacity is mediated primarily through the production IL-10. Here we demonstrate that induction regulatory program in human dependent on metabolic priming event driven by cholesterol metabolism. Synthesis intermediate geranylgeranyl pyrophosphate (GGPP) was required to specifically drive IL-10 production, attenuate Th1 responses. Furthermore, GGPP-dependent protein modifications controlled...
<h3>Background</h3> The αβ T cell receptor (TCR) has immense diversity, primarily for peptide-MHC (pMHC) complexes that clonally interact with complementarity-determining region (CDR)3 motifs assembled by quasi-random somatic gene rearrangement of TCRα and TCRβ segments. This adaptive biology is shown to an even greater extent TCRγδ its ligands being qualitatively more diverse than pMHC. However, can also function as innate whereby germline-encoded variable γ residues are sufficient engage...