A5101871931- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Immune Cell Function and Interaction
- Cervical Cancer and HPV Research
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Immune responses and vaccinations
- T-cell and B-cell Immunology
- SARS-CoV-2 detection and testing
- COVID-19 epidemiological studies
- Vaccine Coverage and Hesitancy
- Long-Term Effects of COVID-19
- CAR-T cell therapy research
- Venous Thromboembolism Diagnosis and Management
- Cardiac, Anesthesia and Surgical Outcomes
- T-cell and Retrovirus Studies
- Virus-based gene therapy research
- Reproductive System and Pregnancy
- Poxvirus research and outbreaks
- Hepatitis B Virus Studies
- Molecular Biology Techniques and Applications
- Herpesvirus Infections and Treatments
- Viral-associated cancers and disorders
- Diagnosis and Treatment of Venous Diseases
- Monoclonal and Polyclonal Antibodies Research
King's College London
1992-2024
Wellcome Trust
2023
Royal Free London NHS Foundation Trust
2020-2022
Medawar Building for Pathogen Research
1991
University College London
1990-1991
Improved understanding and management of COVID-19, a potentially life-threatening disease, could greatly reduce the threat posed by its etiologic agent, SARS-CoV-2. Toward this end, we have identified core peripheral blood immune signature across 63 hospital-treated patients with COVID-19 who were otherwise highly heterogeneous. The includes discrete changes in B myelomonocytic cell composition, profoundly altered T phenotypes, selective cytokine/chemokine upregulation SARS-CoV-2-specific...
The efficacy and safety profiles of vaccines against SARS-CoV-2 in patients with cancer is unknown. We aimed to assess the immunogenicity BNT162b2 (Pfizer-BioNTech) vaccine cancer.
BackgroundThe effectiveness of SARS-CoV-2 vaccines in older adults living long-term care facilities is uncertain. We investigated the protective effect first dose Oxford-AstraZeneca non-replicating viral-vectored vaccine (ChAdOx1 nCoV-19; AZD1222) and Pfizer-BioNTech mRNA-based (BNT162b2) residents terms PCR-confirmed infection over time since vaccination.MethodsThe VIVALDI study a prospective cohort that commenced recruitment on June 11, 2020, to investigate transmission, outcomes, immunity...
Abstract Checkpoint inhibition (CPI), particularly that targeting the inhibitory coreceptor programmed cell death protein 1 (PD-1), has transformed oncology. Although CPI can derepress cancer (neo)antigen-specific αβ T cells ordinarily show PD-1-dependent exhaustion, it also be efficacious against cancers evading recognition. In such settings, γδ have been implicated, but functional relevance of PD-1 expression by these is unclear. Here we demonstrate intratumoral TRDV1 transcripts (encoding...
SummaryBackgroundSARS-CoV-2 infection represents a major challenge for long-term care facilities (LTCFs) and many residents staff are seropositive following persistent outbreaks. We aimed to investigate the association between SARS-CoV-2 antibody status at baseline subsequent in this population.MethodsWe did prospective cohort study of (aged <65 years) >65 100 LTCFs England Oct 1, 2020, Feb 2021. Blood samples were collected June November, baseline, 2 4 months thereafter tested IgG...
ABSTRACT Background The efficacy and safety profile of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have not been definitively established in immunocompromised patient populations. Patients with a known cancer diagnosis were hitherto excluded from trials the currently clinical use. Methods This study presents data on immune BNT162b2 (Pfizer-BioNTech) vaccine 54 healthy controls 151 mostly elderly patients solid haematological malignancies, respectively,...
A Correction to this paper has been published: https://doi.org/10.1038/s41591-020-01186-5
Abstract Person-to-person transmission of SARS-CoV-2 virus has triggered a global emergency because its potential to cause life-threatening Covid-19 disease. By comparison paucisymptomatic clearance by most individuals, been proposed reflect insufficient and/or pathologically exaggerated immune responses. Here we identify consensus peripheral blood signature across 63 hospital-treated patients who were otherwise highly heterogeneous. The core conspicuously blended adaptive B cell responses...
Abstract Background The effectiveness of SARS-CoV-2 vaccines in frail older adults living Long-Term Care Facilities (LTCFs) is uncertain. We estimated protective effects the first dose ChAdOx1 and BNT162b2 against infection this population. Methods Cohort study comparing vaccinated unvaccinated LTCF residents England, undergoing routine asymptomatic testing (8 December 2020 - 15 March 2021). relative hazard PCR-positive using Cox proportional hazards regression, adjusting for age, sex, prior...
Whereas pathogen-specific T and B cells are a primary focus of interest during infectious disease, we have used COVID-19 to ask whether their emergence comes at cost broader cell repertoire disruption. We applied genomic DNA-based approach concurrently study the immunoglobulin-heavy (IGH) receptor (TCR) β δ chain loci 95 individuals. Our detected anticipated focusing for IGH repertoire, including expansions clusters related sequences temporally aligned with SARS-CoV-2–specific...
Elicitation of allergic contact dermatitis (ACD), an inflammatory type 4 hypersensitivity disease, induces skin infiltration by polyclonal effector CD8 αβ T cells and precursors tissue-resident memory (T
Background: The effectiveness of SARS-CoV-2 vaccines in frail older adults living Long-Term Care Facilities (LTCFs) is uncertain. We estimated protective effects the first dose ChAdOx1 and BNT162b2 against infection this population. Methods: Cohort study comparing vaccinated unvaccinated LTCF residents England, undergoing routine asymptomatic testing (8 December 2020 - 15 March 2021). relative hazard PCR-positive using Cox proportional hazards regression, adjusting for age, sex, prior...
Abstract Previous studies have shown that dendritic cells are the most potent inducers of T cell proliferation in vitro and this is reflected release interleukin (IL) 2 into culture supernatants during cell‐T interaction. However, role cells, and, indeed, antigen‐presenting step, has not yet been explored with respect to other cell‐derived cytokines, either a qualitative or relative fashion. In study, therefore, we examined comparative different (APC) as cytokine allogeneic responses. We...
An amendment to this paper has been published and can be accessed via a link at the top of paper.
Abstract Background SARS-CoV-2 infection represents a major challenge for Long Term Care Facilities (LTCFs) and many residents staff are now sero-positive following persistent outbreaks. We investigated the relationship between presence of specific antibodies subsequent in this population. Methods Prospective cohort study 100 LTCFs England October 2020 February 2021. Blood samples were collected at baseline (June 2020), 2 4 months tested IgG to nucleocapsid spike protein. PCR testing was...
Three murine major histocompatibility complex (MHC) class II-restricted T cell determinants were identified in the capsid protein L1 of human papillomavirus (HPV) type 16. Peptides derived from HPV-16 L1, which contain putative epitopes located by a predictive algorithm, synthesized and tested for lymphoproliferative activity direct immunization, followed vitro assay responses to peptides or recombinant L1. The MHC restriction stimulatory was determined using blocking monoclonal antibodies...
Human papillomavirus type 6 (HPV-6) is the causative agent of condyloma acuminata, a common sexually transmitted disease. Virus-like particles (VLPs) assembled from L1 major capsid protein represent promising candidates for prophylactic vaccines. However, any intratype sequence variation among HPV-6 ORFs will influence which used vaccine according to its prevalence in population and propensity VLP production. Therefore, we have analysed entire nucleotide 17 clinical isolates London area. We...
Summary Background Emerging pandemics place immense strains on healthcare systems that may be ameliorated by rapid development of biomarkers whose measurements predict disease severity and additionally inform about causation. Conspicuously, such routine measures rarely include immunological cytokines or chemokines, despite their contributions to host protection immunopathology. Methods Multiplex bead-array ELISA-based serum cytokine chemokine measurements, routinely employed clinical...