A5006128512- Antibiotic Use and Resistance
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Geriatric Care and Nursing Homes
- Patient Satisfaction in Healthcare
- Bacterial Identification and Susceptibility Testing
- COVID-19 epidemiological studies
- Urinary Tract Infections Management
- SARS-CoV-2 detection and testing
- Pediatric Urology and Nephrology Studies
- Frailty in Older Adults
- Hepatitis C virus research
- Long-Term Effects of COVID-19
- Vaccine Coverage and Hesitancy
- Antimicrobial Resistance in Staphylococcus
- COVID-19 and healthcare impacts
- COVID-19 and Mental Health
- Respiratory viral infections research
- Health disparities and outcomes
- Influenza Virus Research Studies
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Healthcare Systems and Technology
- Pneumonia and Respiratory Infections
- Colorectal Cancer Screening and Detection
University College London
2016-2025
UK Health Security Agency
2023-2024
UCL Biomedical Research Centre
2024
University College Hospital
2024
Issues Research
2024
Institute of Informatics of the Slovak Academy of Sciences
2018-2022
Health Data Research UK
2020-2021
Foundation University Medical College
2021
Quaid-i-Azam University
2021
University College of Islamabad
2021
BackgroundThe medical, societal, and economic impact of the coronavirus disease 2019 (COVID-19) pandemic has unknown effects on overall population mortality. Previous models mortality are based death over days among infected people, nearly all whom thus far have underlying conditions. Models not incorporated information high-risk conditions or their longer-term baseline (pre-COVID-19) We estimated excess number deaths 1 year under different COVID-19 incidence scenarios varying levels...
BackgroundThe effectiveness of SARS-CoV-2 vaccines in older adults living long-term care facilities is uncertain. We investigated the protective effect first dose Oxford-AstraZeneca non-replicating viral-vectored vaccine (ChAdOx1 nCoV-19; AZD1222) and Pfizer-BioNTech mRNA-based (BNT162b2) residents terms PCR-confirmed infection over time since vaccination.MethodsThe VIVALDI study a prospective cohort that commenced recruitment on June 11, 2020, to investigate transmission, outcomes, immunity...
To measure trends in antibiotic prescribing UK primary care relation to nationally recommended best practice. A descriptive study linking individual patient data on diagnosis and prescription a large database, covering 537 general practices during 1995–2011. The proportion of cough/cold episodes for which antibiotics were prescribed decreased from 47% 1995 36% 1999, before increasing 51% 2011. There was marked variation by practice 2011 [10th–90th percentile range (TNPR) 32%–65%]. Antibiotic...
BackgroundLong-term care facilities (LTCFs) have reported high SARS-CoV-2 infection rates and related mortality, but the proportion of infected people among those who survived, duration antibody response to natural infection, is unknown. We determined prevalence stability nucleocapsid antibodies (the standard assay for detection previous infection) in staff residents LTCFs England.MethodsThis was a prospective cohort study 65 years or older younger 201 England between March 1, 2020, May 7,...
SummaryBackgroundSARS-CoV-2 infection represents a major challenge for long-term care facilities (LTCFs) and many residents staff are seropositive following persistent outbreaks. We aimed to investigate the association between SARS-CoV-2 antibody status at baseline subsequent in this population.MethodsWe did prospective cohort study of (aged <65 years) >65 100 LTCFs England Oct 1, 2020, Feb 2021. Blood samples were collected June November, baseline, 2 4 months thereafter tested IgG...
Abstract Background epidemiological data on COVID-19 infection in care homes are scarce. We analysed from a large provider of long-term for older people to investigate and mortality during the first wave pandemic. Methods cohort study 179 UK with 9,339 residents 11,604 staff. used manager-reported daily tallies estimate incidence suspected confirmed staff residents. Individual-level electronic health records 8,713 were model risk factors infection, attributable mortality. Results 2,075/9,339...
The SARS-CoV-2 omicron variant (B.1.1.529) is highly transmissible, but disease severity appears to be reduced compared with previous variants such as alpha and delta. We investigated the risk of severe outcomes following infection in residents long-term care facilities.We did a prospective cohort study facilities England who were tested regularly for between Sept 1, 2021, Feb 2022, participants VIVALDI study. Residents eligible inclusion if they had positive PCR or lateral flow device test...
INHALE investigated the impact of seeking pathogens by PCR on antibiotic stewardship and clinical outcomes in hospital-acquired ventilator-associated pneumonia (HAP VAP). This pragmatic multicentre, open-label RCT enrolled adults children with suspected HAP VAP at 14 ICUs. Patients were randomly allocated to standard care, or rapid in-ICU syndromic coupled optional prescribing guidance. Co-primary superiority 24 h non-inferiority cure days post-randomisation. Secondary included mortality,...
Background: Reducing inappropriate antibiotic prescribing in primary care is a public health priority.
Residents and staff in long-term care facilities have been prioritised for vaccination against SARS-CoV-2, but data on potential waning of vaccine effectiveness the effect booster doses this vulnerable population are scarce. We aimed to evaluate one, two, three infection severe clinical outcomes residents England over first year following roll-out.
Abstract Third-dose coronavirus disease 2019 vaccines are being deployed widely but their efficacy has not been assessed adequately in vulnerable older people who exhibit suboptimal responses after primary vaccination series. This observational study, which was carried out by the VIVALDI study based England, looked at spike-specific immune 341 staff and residents long-term care facilities received an mRNA vaccine following dual series with BNT162b2 or ChAdOx1. strongly increased antibody...
Introduction There is a growing trend to use storytelling as research tool extract information and/or an intervention effect change in the public knowledge, attitudes and behaviour (KAB) relation health issues, primarily those with strong element of disease prevention. However, evidence its either or both capacities limited. This protocol proposes systematic narrative review peer-reviewed, published literature on within arena. Methods analysis Medline, EMBASE, PsycINFO, ERIC (Educational...
Background The medical, health service, societal and economic impact of the COVID-19 emergency has unknown effects on overall population mortality. Previous models mortality are based death over days among infected people, nearly all whom (to date at least) have underlying conditions. Models not incorporated information high risk conditions or their longer term background (pre-COVID-19) We estimated excess number deaths 1 year under different incidence rates differing impacts. Methods Using...
Abstract Background The effectiveness of SARS-CoV-2 vaccines in frail older adults living Long-Term Care Facilities (LTCFs) is uncertain. We estimated protective effects the first dose ChAdOx1 and BNT162b2 against infection this population. Methods Cohort study comparing vaccinated unvaccinated LTCF residents England, undergoing routine asymptomatic testing (8 December 2020 - 15 March 2021). relative hazard PCR-positive using Cox proportional hazards regression, adjusting for age, sex, prior...