A5051929110- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Infant Nutrition and Health
- Immunotherapy and Immune Responses
- Neonatal Respiratory Health Research
- RNA Research and Splicing
- Preterm Birth and Chorioamnionitis
- Pancreatic function and diabetes
- Neonatal and Maternal Infections
- Immune Response and Inflammation
- Sepsis Diagnosis and Treatment
- Diabetes and associated disorders
- Cancer Immunotherapy and Biomarkers
- Viral Infections and Vectors
- Zoonotic diseases and public health
- Mosquito-borne diseases and control
- Molecular Biology Techniques and Applications
- RNA modifications and cancer
- DNA Repair Mechanisms
- RNA and protein synthesis mechanisms
- Cancer-related Molecular Pathways
- Food Allergy and Anaphylaxis Research
- Metabolism, Diabetes, and Cancer
King's College London
2019-2024
Guy's Hospital
2024
Jackson Laboratory
1992-2007
Abstract Bacterial infections are a major cause of mortality in preterm babies, yet our understanding early-life disease-associated immune dysregulation remains limited. Here, we combine multi-parameter flow cytometry, single-cell RNA sequencing and plasma analysis to longitudinally profile blood from very babies (<32 weeks gestation) across episodes invasive bacterial infection (sepsis). We identify dynamically changing signature sepsis, including lymphopenia, reduced dendritic cell...
Abstract Infection and infection-related complications are important causes of death morbidity following preterm birth. Despite this risk, there is limited understanding the development immune system in those born prematurely, how influenced by perinatal factors. Here we prospectively longitudinally follow a cohort babies before 32 weeks gestation. We demonstrate that babies, including extremely prematurely (<28 weeks), capable rapidly acquiring some adult levels functionality, which...
We describe unexpected alterations in the non‐obese diabetic (NOD/Lt) mouse model of type 1 diabetes (T1D) following forced β‐cell expression non‐mammalian genes ligated to an insulin promoter sequence. These include jellyfish green fluorescent protein (GFP), useful for identification, and bacteriophage P1 Cre recombinase, necessary β cell–specific ablation a gene using Cre‐ loxP system. Homozygous GFP, driven by (MIP‐GFP) single transgenic line NOD mice, produced T1D postnatal mice that was...
Background: Dengue poses a common conundrum to the emergency care pediatrician regarding requirement of admission anticipating complications in critical phase or following patient on an outpatient basis Objectives: To study clinical and investigative profile dengue infection utility parameters as predictive markers for early identification severe dengue. Method: All hospitalized children satisfying inclusion criteria were studied. Detailed history, examination relevant investigations done....
The aim of this paper was to show that the adoptive immunotherapy (AIT) established tumors resulted in activation defined lymphocyte-associated genes at site rejection. C57BL/6J mice bearing moderately immunogenic syngeneic MCA/76-9 sarcoma received combination therapy 10 days after tumor cell implantation. This consisted a single i.p. injection cyclophosphamide (CY) followed by i.v. tumor-sensitized T cells (CY/AIT). previously observed situ differential expansion tumor-infiltrating...
Abstract Infection and infection-related complications are important causes of death morbidity following preterm birth. Despite this, there is limited understanding the development immune system in those born prematurely how it influenced by perinatal factors. To investigate we prospectively longitudinally followed a cohort babies before 32 weeks gestation. We demonstrated that babies, including extremely prematurely, were capable rapidly acquiring adult levels functionality; maturation...