A5082422765- Cancer Cells and Metastasis
- Air Quality and Health Impacts
- Cancer, Hypoxia, and Metabolism
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Epigenetics and DNA Methylation
- Brazilian cultural history and politics
- Education and Public Policy
- NF-κB Signaling Pathways
- Education Pedagogy and Practices
- Biomarkers in Disease Mechanisms
- Neonatal Respiratory Health Research
- Glioma Diagnosis and Treatment
- Periodontal Regeneration and Treatments
- Mesenchymal stem cell research
- Energy and Environment Impacts
- Immune cells in cancer
- Sarcoidosis and Beryllium Toxicity Research
- Ubiquitin and proteasome pathways
- Tracheal and airway disorders
- Neuroblastoma Research and Treatments
- Effects of Radiation Exposure
- Occupational and environmental lung diseases
- Geography and Environmental Studies
- Ferroptosis and cancer prognosis
- Cancer Research and Treatments
The Francis Crick Institute
2022-2024
Universidade de São Paulo
2019-2020
University of Glasgow
2020
Universidade Evangelica de Goiás
2019
Hospital de Clínicas de Porto Alegre
2016
Hospital Prof. Dr. Fernando Fonseca
2014
A key step for metastatic outgrowth involves the generation of a deeply altered microenvironment (niche) that supports malignant behavior cancer cells. The complexity niche has posed significant challenge in elucidating underlying programs driving its origin. Here, by focusing on early stages breast metastasis to lung mice, we describe cancer-dependent chromatin remodeling and activation developmental alveolar type 2 (AT2) cells within niche. We show can prime AT2 into reprogrammed...
Invasive breast cancer accounts for 7% of all cancer-related deaths, with the lungs being a common site metastases. At same time, lower respiratory tract infections are cause morbidity and mortality worldwide. Acute viral induce transitional changes in lung; however, impact these on metastasis initiation progression remains unclear. Using primary murine MMTV-PyMT cells an experimental lung model, we show that induced by syncytial virus (RSV) infection impair tumor cell seeding early...
Abstract Environmental carcinogenic exposures are major contributors to global disease burden yet how they promote cancer is unclear. Over 70 years ago, the concept of tumour promoting agents driving latent clones expand was first proposed. In support this model, recent evidence suggests that human tissue contains a patchwork mutant clones, some which harbour oncogenic mutations, and many environmental carcinogens lack clear mutational signature. We hypothesised carcinogen, <2.5μm...
A gestão democrática é um dos pilares fundamentais da educação pública no Brasil, sendo o projeto político-pedagógico (PPP) documento responsável por definir a identidade escola. Este estudo tem como objetivo demonstrar relevância para elaboração e implementação do PPP nas escolas públicas brasileiras, destacando sua influência na prática cotidiana escolar. Para tanto, trabalho realiza uma revisão bibliográfica sobre relação entre construção aplicação PPP, enfatizando importância de espaço...
<title>Abstract</title> Metastatic relapse can occur months to years after the cancer is first diagnosed, and it relies on reactivation of disseminated tumour cells (DTCs) that have lied dormant in secondary organs. The acquisition maintenance a dormancy phenotype are tightly regulated by interaction DTCs with their microenvironment. In bone, program activated metastatic competent how induced largely unknown. We here present strategy engineer mouse-to-mouse extramedullary (EM) which...
KRAS oncogenic mutations are widespread in lung cancer and, because direct targeting of has proven to be challenging, KRAS-driven cancers lack effective therapies. One alternative strategy for developing targeted therapies is identify downstream targets involved promoting important malignant features, such as the acquisition a stem-like and metastatic phenotype. Based on previous studies showing that activates nuclear factor kappa-B (NF-κB) through inhibitor kinase β (IKKβ) promote...
Background: Mesenchymal stromal cells (MSC) are being tested for the treatment of immune diseases. MSC present in several adult tissues which milieu may influence behavior particularly under inflammatory conditions. Additionally, culture conditions also can modify cell function or state activation. Methods: To address source on its characteristics, we studied a xenofree, platelet lysate supplemented from dental pulp, adipose tissue and bone marrow, co-cultured with isolated T PBMC subset,...
A key step for metastatic outgrowth involves the generation of a deeply altered microenvironment (niche) that supports malignant behavior cancer cells. However, it is unclear whether fundamental program driving this de novo cellular environment can be identified. Here, by focusing on breast metastasis to lung, we describe cancer-dependent activation developmental programs in alveolar epithelial We have identified relationship linking high competency lung with induction multilineage state AT2...