A5060776127- Cancer Cells and Metastasis
- Immune cells in cancer
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Epigenetics and DNA Methylation
- Hippo pathway signaling and YAP/TAZ
- Neonatal Respiratory Health Research
- Cervical Cancer and HPV Research
- Cancer Research and Treatments
- Immunotherapy and Immune Responses
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Genomics and Diagnostics
- Cancer-related Molecular Pathways
- S100 Proteins and Annexins
- Ubiquitin and proteasome pathways
- Cancer, Hypoxia, and Metabolism
- Cell Adhesion Molecules Research
- Wnt/β-catenin signaling in development and cancer
- Glioma Diagnosis and Treatment
- MicroRNA in disease regulation
- Air Quality and Health Impacts
- Nanoplatforms for cancer theranostics
- Enzyme Structure and Function
- Nonmelanoma Skin Cancer Studies
- Biomarkers in Disease Mechanisms
- Click Chemistry and Applications
The Francis Crick Institute
2015-2024
The Honourable Society of Lincoln's Inn
2013-2019
Cancer Research UK
2012-2015
École Polytechnique Fédérale de Lausanne
2007-2011
Centre International de Recherche sur le Cancer
2003-2004
German Cancer Research Center
2000-2003
DKFZ-ZMBH Alliance
2000-2002
The skin is a squamous epithelium that continuously renewed by population of basal layer stem/progenitor cells and can heal wounds. Here we show YAP TAZ are nuclear localised in the elevated upon wound healing. Skin-specific deletion both adult mice slows proliferation cells, leads to hair loss impairs regeneration after wounding. Contact with extracellular matrix consequent Integrin-Src signalling key determinant YAP/TAZ localisation tumours. basement membrane lost differentiating daughter...
ROCK-Myosin II drives fast rounded-amoeboid migration in cancer cells during metastatic dissemination. Analysis of human melanoma biopsies revealed that amoeboid with high Myosin activity are predominant the invasive fronts primary tumors proximity to CD206+CD163+ tumor-associated macrophages and vessels. Proteomic analysis shows controls an immunomodulatory secretome, enabling recruitment monocytes their differentiation into tumor-promoting macrophages. Both associated support abnormal...
In this study we investigate the mechanism of intracellular pH change and its role in malignant transformation using E7 oncogene human papillomavirus type 16 (HPV16). Infecting NIH3T3 cells with recombinant retroviruses expressing HPV16 or a deficient mutant show that alkalinization is specific. which can be turned on followed by induction expression, demonstrate cytoplasmic an early event was driven stimulation Na + /H exchanger activity via increase affinity NHE‐1 proton regulatory site....
Despite substantial clinical benefit of targeted and immune checkpoint blockade-based therapies in melanoma, resistance inevitably develops. We show cytoskeletal remodeling changes expression activity ROCK-myosin II pathway during acquisition to MAPK inhibitors. regulates myosin activity, but after initial therapy response, drug-resistant clones restore increase survival. High correlates with aggressiveness, identifying therapy- immunotherapy-resistant melanomas. Survival resistant cells is...
Centrosomal abnormalities, in particular centrosome amplification, are recurrent features of human tumors. Enforced amplification vivo plays a role tumor initiation and progression. However, occurs only subset cancer cells, thus, partly due to this heterogeneity, the contribution tumors is unknown. Here, we show that supernumerary centrosomes induce paracrine-signaling axis via secretion proteins, including interleukin-8 (IL-8), which leads non-cell-autonomous invasion 3D mammary organoids...
The skin is a squamous epithelium that continuously renewed by population of basal layer stem/progenitor cells and can heal wounds. Here, we show the transcription regulators YAP TAZ localise to nucleus in are elevated upon wound healing. Skin-specific deletion both adult mice slows proliferation cells, leads hair loss impairs regeneration after wounding. Contact with extracellular matrix consequent integrin-Src signalling key determinant nuclear localisation YAP/TAZ tumours. basement...
Abstract Melanoma is a highly aggressive tumour that can metastasize very early in disease progression. Notably, melanoma disseminate using amoeboid invasive strategies. We show here high Myosin II activity, levels of ki-67 and tumour-initiating abilities are characteristic cells. Mechanistically, we find WNT11-FZD7-DAAM1 activates Rho-ROCK1/2-Myosin plays crucial role regulating potential, local invasion distant metastasis formation. Importantly, cells express both proliferative gene...
Several studies have suggested the involvement of cutaneous human papillomaviruses (HPVs) in development nonmelanoma skin cancers. Here we characterized vitro properties E7 proteins three HPV types, 10, 20, and 38, which are frequently detected specimens. We show that HPV38 is able to inactivate tumor suppressor pRb induces loss G(1)/S transition control, a key event carcinogenesis. In contrast, HPV10 HPV20 do not display these transforming activities. also two early E6 sufficient corrupt...
ABSTRACT It has previously been shown that the E7 protein from cutaneous human papillomavirus type 1 (HPV1), which is associated with benign skin lesions, binds product of tumor suppressor gene retinoblastoma (pRb) an efficiency similar to oncogenic HPV 16. Despite this ability, HPV1 does not display any activity in transforming primary cells. In addition, two viral proteins differ their mechanisms targeting pRb. HPV16 promotes pRb destabilization, while cells expressing do show decrease...
Abstract Converting carcinomas in benign oncocytomas has been suggested as a potential anti-cancer strategy. One of the oncocytoma hallmarks is lack respiratory complex I (CI). Here we use genetic ablation this enzyme to induce indolence two cancer types, and show reversed by allowing stabilization Hypoxia Inducible Factor-1 alpha (HIF-1α). We further that on long run CI-deficient tumors re-adapt their inability respond hypoxia, concordantly with persistence human oncocytomas. demonstrate...